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SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617
SAN DIEGO (KGTV) - It's the perfect weekend to get out and enjoy San Diego!The 10th annual San Diego Festival of Science & Engineering returns to Petco Park, packing the ballpark with more than 130 free exhibits. The expo will give attendees hands-on opportunities and experiments centered around STEM education.Seaport Village will also host the free Spring Busker Festival, featuring professional street performers displaying their incredible talents and acts that are sure to amaze.MORE: Exploring San Diego funComedian Jeff Dunham and San Diego Film Festival will also headline this weekend.Here's a look at what's going on around San Diego this weekend:THURSDAYJeff DunhamWhere: Valley View Casino Center; Cost: Comedian Jeff Dunham brings his talent for many identities to Valley View Casino Center with his Passively Aggressive tour. Dunham's show will take on a special plot, as his cohorts Walter, Achmed the Dead Terrorist, Bubba J, and Peanut consider bringing a new member into their lives. San Diego Film Week 2018Where: Museum of Photographic Arts; Cost: - 0(Thursday - Sunday) San Diego's ten-day celebration of cinema will feature more than 100 local, national, and international films at the Museum of Photographic Arts and other locations around San Diego. The festival also includes workshops, parties, and panels.FRIDAY 1416
SAN DIEGO (KGTV) - Jo Anne Bilodeau finds peace inside the grounds of her serene San Carlos apartment complex, filled with greenery, benches, a clubhouse and a pool.Even her rent is less than ,100 a month. "It kind of feels like a sanctuary," she says. But Bilodeau's days in San Diego could be numbered, all because of a specialty shot she takes every 12 weeks. RELATED: Making It in San Diego: Prescription medication costs impacting San Diego families"It's just scary," Bilodeau says. "It makes you feel like you're in limbo all the time because you don't know the exact cost of the drug until you get a bill."Bilodeau suffers from Rheumatoid Arthritis, an autoimmune disease that causes the body to mistakenly attack the joints. She's about to turn 71 and on medical leave from her job, meaning her company health benefits are expiring. That leaves her with just Medicare, and what she believes will be a ,300 co-insurance payment on the drug."I have my days," she says. "I have meltdowns where I just cry because I'm worried and scared."Bilodeau isn't the only one with that anxiety.A new study by AARP says the price for specialty prescription drugs, ones that are generally infused or injected, rose 7 percent in 2017. That's more than three times the rate of inflation. The average annual cost for these drugs is nearly ,000. RELATED: Making It in San Diego: How to save money on your prescriptions"The prices for those medications has risen dramatically," said Leslie Ritter, a senior director at the National Multiple Sclerosis society, a condition that also requires specialty drugs.Ritter says patients on the medications have skipped doses and racked up credit card debt. "Medications only work if you're adhering to them, and you're taking them as prescribed," she says. Federal and State governments are now moving legislation to help lower prices and increase transparency. In the meantime, Leigh Purvis, of the AARP Public Policy Institute, said the best thing to do is for patients to talk to their health care providers to see if there is a less expensive generic alternative to treat the same condition.Drug manufacturers themselves also offer patient assistance programs to those who are eligible. However, they are only available to privately and commercially insured patients, not those on Medicare. 2338
SAN DIEGO (KGTV) -- Millions of dollars have been raised and spent in the race to fill the seat for the 50th Congressional District.According to a recently released 10News/Union-Tribune scientific poll, Democrat Ammar Campa-Najjar and Republican Darrell Issa have emerged as the favorites to represent East County's 50th Congressional District.Federal Election Commission (FEC) records show Issa is currently leading in the money game as well. 451
SAN DIEGO (KGTV) -- Leonardo Hurtado Ibarra is being remembered as a family man with a complex and troubled life.“He’d always keep a smile on his face regardless of whatever he was going through," Abril Huerta told ABC 10News.Ibarra, 25, was shot and killed after allegedly pointing a revolver at a San Diego Police Department officer in Downtown San Diego on Saturday night.According to police, officers recognized Ibarra from a wanted poster in connection with a robbery that happened last week. Police said officers tried to talk with Ibarra but he walked away.Ibarra then dropped some items from his arms and "reached into his waistband," according to police. That's when officers, fearing for their lives, opened fire, police said.RELATED: SDPD release surveillance video, body cam footage from officer-involved shooting in Downtown San DiegoABC 10News asked Huerta if Ibarra was known to carry a weapon. She said Ibarra "wasn’t a saint" and that he had a "complicated background."Ibarra was sentenced to three years in prison stemming from a domestic abuse case in 2013, according to court records obtained by ABC 10News.Huerta, who said she was the love of Ibarra’s life, told ABC 10News that he leaves behind three children.“He loved his family," Huerta told 10News in a statement. "He was the most loyal individual you could ever meet and he’d give you the shirt off his back if you were in need."“He only wanted to defend himself from any harm that were to come his way,” she said. The police department has not released the names of the officers involved in the shooting. The case will be reviewed by the county District Attorney's Office to determine if the officers are subject to any criminal liability, according to police.San Diego Police could not comment further while the investigation is ongoing. 1824