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SAN DIEGO (KGTV) — The National Institutes of Health highlighted research Tuesday out of UC San Diego that could unlock a new way to treat COVID-19.The research reveals new insight into how the coronavirus hijacks cells, and how doctors might be able to set traps or decoys to combat the virus. The findings were published in the journal Cell last month.“It does open up another avenue for a potential treatment,” said UC San Diego distinguished professor Dr. Jeffrey Esko. “It’s not a cure. It would be something that would tamp down infection potentially.”Since January, scientists around the world have understood that SARS-Co-V2, the official name of the new coronavirus, enters cells by latching onto a specific receptor on the cell’s surface, called ACE2.The UCSD team, led by Dr. Esko and visiting scholar Dr. Thomas Clausen, discovered that this entry mechanism is actually a two-step process, and the virus must also attach to a long chain of sugars called heparan sulfate.“We’ve shown this is fundamental to the infectious mechanism, so it needs to be part of every study from now on,” said Clausen.All cells are coated with a complex layer of sugars, or carbohydrates, called glycans. Heparan sulfate is one type of glycan that is known to play a key role in the infection process in several viruses, including herpes and other coronaviruses.It’s a complicated process to picture so the researchers offer an analogy: imagine a bird, soaring over trees, hunting a worm on the forest floor. The bird is the coronavirus and the trees are the thick layer of glycans that coat the surface of the cell.To reach the worm, which in this case is the receptor ACE2, the bird must navigate its way through the trees, specifically through heparan sulfate.The UCSD found that by removing the heparan sulfate trees with an enzyme, they were able to prevent the virus from infecting cells. In laboratory testing, they also found a second technique worked to foil the virus: introducing more trees as bait.The team found that heparin, an FDA-approved drug that is similar in structure to heparan sulfate, successfully acted as decoy. Heparin is a widely used drug designed to treat blood clots. Since blood clots and strokes are common complications with COVID-19, many doctors already administer heparin to patients.The UCSD team demonstrated that the two approaches can block infection in lab-grown cells about 80 to 90 percent of the time.“Certainly in the laboratory you can demonstrate that it works, but to deploy it and use it as a therapeutic has not been demonstrated,” Esko said.The NIH noted that more studies are planned to explore whether heparin, heparan sulfate, or drugs that target heparan sulfate might yield a viable COVID-19 treatment.Dr. Esko said he’s already been in talks with companies that plan to use their study as a rationale for a clinical trial.“It is very humbling when you realize we’re working on a pandemic right now, and maybe what we’ve done can contribute to a treatment for the disease,” he said. 3038

SAN DIEGO (KGTV) — The community of Barrio Logan welcomed residents to shop in the streets after months of coronavirus’ impact. Saturday, Aug. 4, the “Walk the Block” event debuted. Local businesses got permits to move service outdoors to the sidewalk, and the event celebrated the community’s resurgence of business with food, specialty items and music.Business owners like Stephanie, who runs Dreamers and Hustlers Company, a clothing shop with items branded toward the namesake, said the past few months have been hard, but she’s confident Barrio Logan shops will bounce back.“Even during these times we figure out ways we can pick ourselves up and get going again,” she said.Edgar Flores said his shop, Maxa Market, sells products made by local small businesses and entrepreneurs. He’s been able to continue with online sales but said he’s excited to be restocking his storefront and welcoming back in-person customers.“It’s all about being a community, all the people getting together doing this, doing the walkabout,” he said.The Walk the Block event will occur every Saturday from noon to 7 p.m. on Logan Ave. between Chicano Park and 26th St. Masks and social distancing are required. 1200

SAN DIEGO (KGTV) -- The latest water main break Sunday in the Midway District is the latest example of San Diego’s aging water system. But the city is working to fix the issue, replacing more than 100 miles of water transmission and distribution pipes.According to city documents, since 2013, San Diego spent 8 million to repair and replace 116 miles of water transmission and distribution pipes.A total of 72 miles of those repairs were on cast iron pipes, the oldest ones in the system. The project started in 2007 and sparked a rate increase to pay for the work.RELATED: Water main break in Midway District causes flooding, shuts down roadAs older piper are replaced, the city has seen the number of water main breaks decrease. "We have more than 3,000 miles of pipeline," said department spokesperson Brent Eidson, "To do it properly, we're probably always going to be replacing pipes."Throughout the project, older pipes made from concrete or cast iron are being replaced with new PVC pipes. Edison says PVC is the industry standard. Pipes made from the material usually last between 50-75 years.The city says its water system extends more than 400 square miles and moves roughly 172 million gallons per day. Included in that area is 49 water pumping stations, 29 treated water storage facilities, three water treatment plants and more than 3,300 miles of pipelines.The city hopes to have all the cast iron distribution lines replaced by 2018-19. The goal is to have all the larger cast iron transmission mains replaced by 2023. Some of the cast iron pipes are nearly 100 years old.The following numbers were provided to 10News by the Public Utilities Department and list the number of breaks over the last six years.2012: 1022013: 952014: 742015: 632016: 852017: 81 (as of October 20)2018: 29 (as of August 5) 1841

SAN DIEGO (KGTV) - The man who jumped on stage during a Taylor Swift concert and assaulted a security guard was charged Monday with a deadly beating in the Midway area, police said. Christian Ewing, 29, was charged for the death of 57-year-old Gregory Freeman, according to SDPD Homicide Lt. Anthony Dupree. Officers got a 911 call about an assault near the Interstate 5 overpass at 3900 Rosecrans St. the evening of Dec. 5. A witness said a victim was on the ground and another man was hitting him with an object, investigators reported. RELATED: Taylor Swift concert crasher gets probation, ordered to stay away from SwiftPolice arrived at the scene to find Freeman suffering trauma to his upper body. He died three days later of his injuries. The suspect fled the scene, police said.Ewing was arrested on Dec. 21 for a parole violation and rebooked Monday on suspicion of murder. In 2015, Ewing jumped on stage at Petco Park as Taylor Swift was performing. Swift’s personal security guard, David Durkin, told Ewing he was not allowed to be in the area. During a struggle, Ewing seriously injured Durkin. RELATED: Taylor Swift concert crasher ruled mentally fit to stand trialWhen asked why he went up on stage, Ewing replied, "I love that girl," San Diego Police Officer John Clayton testified.Ewing pleaded guilty to assault and violently resisting an officer in the performance of his duties. He was sentenced to two years' probation, and was expected to be supervised by the Probation Department's mentally-ill offender unit. Prosecutors previously said Ewing had several arrests in multiple states, an active warrant for a theft-related offense out of Florida, and a felony conviction for transporting drugs from out-of-state. Dupree said both Ewing and Freeman were homeless.Ewing’s arraignment on the murder charge is scheduled for Dec. 27. Anyone with information about the Midway area assault is asked to call San Diego Police Homicide Unit at 619-531-2293 or Crime Stoppers at 888-580-8477. 2010

SAN DIEGO (KGTV) -- The holiday season may look different this year, but organizations around the county are making the most of the situation.Instead of large gatherings, many San Diego holiday favorites are going virtual while others adapt to the changes in unique ways.(NOTE: SOME EVENTS MAY BE CLOSED FOR A PORTION OF DECEMBER DUE TO CALIFORNIA'S NEW REGIONAL STAY-AT-HOME ORDER.)See the list below for more:Taste of December NightsThis year, Balboa Park’s famed December Nights will look a little different. Swapped for the usual hustle and bustle is Taste of December Nights. The event takes place from Friday, December 4 through Sunday, December 6 from 11 a.m. to 10 p.m. and will feature more than 20 food trucks and vendors. Organizers say all safety protocols by the county will be strictly enforced. This year, customers must remain in their cars and everyone must wear a mask. Click here for more information on the event.Lawrence Family Jewish Community Center Hanukkah CelebrationThis year, the center is hosting a socially distanced traveling Hanukkah celebration. "Hanukkah Happening Hits the Highway" is taking place on December 6 from 11 a.m. to 1 p.m. The center has two car routes planned throughout the county where families travel to three different places to find Jewish landmarks and symbols. While in the car, there will be Hanukkah stories, music, games, and trivia shared. The event is free, but you will need to pre-register. Click here for details on the event.Petco Park Holiday Trail and MarketThe market and trail will take guests through a socially distanced, one-way trail at Petco Park's Gallagher Square, featuring artisan shops, lighting displays, foods and drinks, and unique crafts and gifts.Vendors on the trail will feature seasonal gifts like ornaments, wooden figurines, oils and soaps, and many more stocking stuffers. Visitors will be able to enjoy cider or wine, and delicious bratwurst, shortbread, and other treats along the way.Menorah Lighting in Liberty StationIn partnership with the Chabads of Downtown San Diego and Pacific Beach, Liberty Station plans to host a public menorah lighting on December 10 at 5 p.m. in the Central Promenade.La Mesa's Holidays in the Village La Mesa's Holiday in the Village returns on Dec. 5 from 10 a.m. - 9 p.m. with a craft market, holiday music, a food court, and holiday photo stations. The free event will observe public health orders and precautions and temperature checks will be required to enter. Face coverings and social distancing will also be required.Del Mar Fairgrounds Holidays in Your CarA magnificent display of lights and sounds will ring in the holidays at the Del Mar Fairgrounds this season, with Holidays in Your Car from Dec. 5 - Dec. 24, Dec. 26 - Dec. 30, and Jan. 1 2.More than one million LED lights, holograms, and projection mapping animated to holiday music will take over the fairgrounds for visitors to enjoy their own little sleigh ride, with some displays standing at over 40 feet high.Little Italy Virtual Tree LightingDue to COVID-19, Little Italy will host a virtual tree lighting. Standing at 30-feet tall, the Christmas Tree in the center of Piazza della Famiglia will be lit on December 5 at 5:30 p.m.Old Globe's "How the Grinch Stole Christmas!" and tree lightingThe Old Globe's production of "Dr. Seuss’s How the Grinch Stole Christmas!" won't be taking the theater's stage this year, instead, coming to audiences on the radio and online. The free, audio-only production can be heard on 89.5 FM and can also be streamed on the KPBS website or mobile app, and on smart speakers on Nov. 26, Dec. 5, and Dec. 20 at 12 p.m.; and Dec. 24 at 6 p.m.The 15th annual Globe Christmas Tree Lighting Ceremony will take place virtually on Nov. 22 at 6 p.m. and can be viewed on the Globe's website or social media channels. The tree lighting ceremony will feature songs, videos, and special greetings from company members and The Grinch himself.Winter Wonderland at Hotel del CoronadoThe Hotel del Coronado is bringing holiday magic to the beach, with thousands of sparkling lights, magnificent Christmas trees, and a winter wonderland at The Del’s Windsor Lawn.The holiday fun will include pictures with Santa, a "Frostbite" bar trailer with holiday treats and drinks, and holiday crafts available for sale, including cookie decorating kits, ornaments, and more. Seas 'N' Greetings at Birch AquariumFrom Nov. 28 to Dec. 31, Birch Aquarium is bringing holiday fun to the coast with Seas ‘n’ Greetings. Visitors can enjoy an 18-foot-tall inflatable octopus, check out a rescued Loggerhead Sea Turtle, and visit an outdoor Tide Pool Plaza with juvenile Swell Sharks, Horn Sharks and Round Rays. 4714

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