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The pandemic has raised awareness about convalescent plasma donation to treat coronavirus patients. But for hundreds of thousands of people who rely on regular plasma infusions to survive, a looming shortage is raising alarm bells.Mother, wife and rare disease advocate Deborah Vick lives with myasthenia gravis, a neuromuscular disorder that disrupts nerve to muscle communication.“The messages are no longer being able to reach the muscles to make them work--whether that is to walk or move or swallow or breathe--it's all interconnected,” described Vick.There is no cure, so every two weeks, she requires plasma infusions.“Being in crisis is the worst time to have to wait for treatment,” she explained. “I know, for me, my treatments are every two weeks and days before my treatment starts, my breathing is extremely labored.”Many types of primary immunodeficiency disorders like Vick’s result in an inability to produce antibodies or immunoglobulin to fight off infection.“There's about 250,000 of us in the United States alone,” said John Boyle, president and CEO of the Immune Deficiency Foundation.Canceled drives and fear of COVID-19 exposure, he says, have contributed to a drop in plasma donations for non-COVID therapy.This comes as the Red Cross says hospital distributions of convalescent plasma have increased 250 percent in November compared to September.“To not meet the rising demand is one thing, but to actually have less plasma is potentially very, very, very problematic,” said Boyle.Experts say it takes seven to 12 months to turn around plasma for patient infusion therapies. We are now nine months into the pandemic and a crisis say some could be around the corner.“There is a growing concern about the ability to meet patient clinical need,” said Amy Enfantis, president and CEO of the Plasma Protein Therapeutics Association.She says while the call for convalescent plasma therapies for COVID-19 has raised awareness, there is still an increased need for other rare-disease patients.“Our companies are making therapies every day for patients who have a perpetual need for plasma,” said Enfantis. “And that is ongoing regardless of a pandemic.”For those who rely on plasma donation and infusion treatment like Vick, it could mean the difference between life and death.“The biggest fear is not having the treatments that keep me alive. I mean, reality is I don't know what kind of life I will have, if any, how it will function without my infusions.”It’s why so many are hoping those who can, will give. 2536

The Miami Police Department says what began as disagreement about masks led to an assault on Sunday evening.According to a statement from the Miami Police Department, the incident began at Latin Cafe, a ventanita or coffee shop near Miami International Airport. Surveillance video shows five people milling about outside of the cafe.The Miami Police Department says a few patrons got into an argument about mask compliance. Video shows one customer, wearing a mask and a red shirt, gesturing toward cafe employees and appearing to speak in exaggerated tones toward another customer without a mask.The customer without a mask stepped toward the man in the red shirt, and then a struggle ensued. Additional security footage shows the man in the red shirt falling to the ground. That man's girlfriend saw the incident from her car and ran to help. Police say she was also hit during the scuffle.Miami Police Officer Kiara Delva told WSVN-TV in Miami that the fight left the man in the red shirt "disoriented."Police say they're searching for four people in connection with the incident. It's unclear how many of those people could face charges.Miami currently requires the use of masks in public to prevent the spread of the coronavirus. First-time offenders are issued warnings, while repeat offenders could face fines. 1325

The parents of Payton Summons, who was declared brain-dead, have been granted more time to keep their 9-year-old on a ventilator at a Fort Worth, Texas, hospital.Lawyers for Payton's family filed a new request on Monday to extend a temporary restraining order that would keep her on the machine at Cook Children's Medical Center. The order has been extended until 6 p.m. October 22, according to Justin Moore, a lawyer for Payton's family.Yet on Tuesday, the hospital filed a mandamus challenging that extension and asking for the extended temporary restraining order to be vacated."The judge's decision has put all of us in an incredibly difficult position. As a hospital made up of women and men who made it their careers to save lives, we are truly devastated for this family," a statement from Cook Children's said Wednesday."But when Payton Summons suffered brain death on September 25, she was determined to be dead under clear Texas law and the laws of every other state," the statement said. "There is no treatment that can be provided for her at Cook Children's or any other facility that will change that. To maintain a dead person on mechanical ventilation and insist -- in fact order -- that health care providers continue treating a deceased, deteriorating body is medically, ethically, and morally wrong. We will continue to support this family during this difficult time."After the mandamus was filed Tuesday, Moore tweeted that the move was "legal wrangling.""The hospital is reverting to legal wrangling for an attempt at preventing Payton's parents from looking for facilities to accept their baby girl," he wrote.A previous temporary restraining order against Cook Children's Medical Center was scheduled to expire Monday afternoon after Judge Melody Wilkinson of the 17th District Court of Texas denied a request last week to extend it."The parents want to keep on fighting," Moore told HLN's "Michaela" last week."It's probably the hardest case I've ever had to deal with in my young career," he said. "Just to see this particular situation where parents are just fighting tooth and nail and they're not gaining an inch at all, it's just heartbreaking."Payton has been on the ventilator at Cook Children's Medical Center since late September, after she went into cardiac arrest due to a large tumor in her chest.Last month, she was staying overnight with her grandmother when she suddenly woke up, "screamed for her grandmother to help her and said that she couldn't breathe ... then she collapsed," Payton's mother, Tiffany Hofstetter, told CNN affiliate KTVT in September.Payton was transported to the hospital, and doctors established a heartbeat but put her on a ventilator because she was no longer breathing.She was confirmed brain-dead after a test determined that she did not have brain activity."Brain death, by definition, is irreversible," CNN Chief Medical Correspondent Dr. Sanjay Gupta said in 2014."In the United States and most places, it is legally synonymous with death -- the same as if your heart stops," he said. "But brain death means a total loss of brain activity."Under Texas law, a person is considered dead when they have suffered an irreversible loss of all brain function, the hospital said in a statement in September, according to KTVT."Per our protocol and national pediatric medical standards, a second brain death exam was scheduled to take place by a different physician within 12 hours of the first to complete the legal process of declaring Payton deceased," the hospital said."In addition to dealing with the sudden blow of her cardiac arrest and devastating brain injury, Payton's family is also coping with the news that the arrest was caused by the growth of a very large tumor in her chest that is shutting off her circulatory system."The hospital held off on performing the second brain death examination because Payton's family filed that temporary restraining order against the facility. It was filed in order to keep her on the ventilator until they found another hospital that could take their daughter. The family's co-counsel Paul Stafford said last week that the family contacted about 25 other facilities, but there were no takers."Unfortunately, after 25 out of 28 facilities that were contacted, we had no takers. We have two maybes, and those were preconditioned on certain things which may be life-threatening to Payton if performed," he said.On Wednesday, Moore said on "Michaela" that "the facilities that we've talked to that have presented some preconditions for admittance, they have talked about a tracheostomy being performed. So with that being the case, Cook Children's would have to perform this procedure in order for these facilities to look at taking Payton, and Cook Children's has maintained that they would not perform this procedure."That remains the impediment for acceptance into other facilities," he said.Kim Brown, a spokeswoman for the hospital, said in a statement this month, "Cook Children's has been informed that we no longer have the ability to speak to media about Payton Summons. Although the family previously signed a consent form authorizing the release of information protected by the Health Insurance Portability and Accountability Act (HIPAA), we have been notified by the family's lawyer that the family has revoked their consent for us to speak about Payton's condition."Unfortunately, this means that we are no longer able to provide detailed, factual information regarding this case. We're disappointed that the family has revoked their authorization because we believe that accurate information facilitates fair, balanced and informed reporting."The-CNN-Wire 5684

The Los Angeles Dodgers will play in the World Series for the second year in a row after defeating the Milwaukee Brewers 5-1 Saturday night in the seventh and deciding game of the National League Championship Series. The Dodgers will play the American League champion Boston Red Sox in the World Series, which begins Tuesday.Milwaukee took a 1-0 lead in the bottom of the first inning when star hitter Christian Yelich tagged a 1-0 pitch from Los Angeles starter Walker Buehler for a home run.But the Dodgers' Cody Bellinger answered in the top of the second with a two-run blast after bunt hit by Manny Machado off Brewers starter Jhoulys Chacin. That gave Los Angeles a 2-1 lead.Chacin only pitched two innings and reliever Josh Hader, who had 12 regular-season saves, pitched three strong innings, giving up just one hit and no runs, to keep the Brewers in the game. He struck out four of the 10 batters he faced. 924

The number of mass shootings around the country in 2018 has risen above 300 so far.According to data from the Gun Violence Archive, a total of 314 mass shooting incidents have occurred as of November 19.A shooting injuring four people, including a suspect, at a Chicago hospital and a Monday evening shooting in Denver, injuring at least 4 and killing 1, marked the 315th and 316th mass shootings so far this year, respectively.In 2017, the U.S. saw a total of 346 mass shootings. See statistics for other years here.A November shooting at a bar in Globe, Arizona, which left three dead and one other?injured, marked the 309th mass shooting.There doesn't seem to be an official definition for a "mass shooting" in the United States, but according to the Gun Violence Archive, a mass shooting is described as four or more individuals being shot or killed in the same general time and location. RELATED: School shootings in U.S.: When, where each shooting has occurred in 2018The F.B.I. defines a "mass killing" as the killing of three or more people in a public place, but the federal agency also defines a "mass murderer" as someone who has killed four or more people in the same location.The Gun Violence Archive lists itself as a not-for-profit organization that documents gun violence and gun crime nationally. 1376