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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.
BEIJING, Nov. 26 (Xinhua) -- In response to the government's call to build a greener economy, China's transport authorities have taken a slew of measures to promote energy saving and emission reductions in the sector.Under the sector's funding policy unveiled earlier this year, 122 emission-cutting projects in the industry have received financial support totalling 250 million yuan (39.3 million U.S. dollars). Encouraged by the special funds, another 8.06 billion yuan in investment went to the projects, according to He Jianzhong, spokesman for the Ministry of Transport (MOT).The projects were estimated to be able to save 315,000 metric tons of coal equivalent, replace 224,000 metric tons of fuel oil and reduce carbon dioxide emission by 1.14 million metric tons, He said.Meanwhile, the MOT has launched nationwide programs to promote low-carbon traffic. It has carried out 80 pilot projects on emission control and designated 10 cities as pilot areas to study and promote green transport system, including Tianjin, Shenzhen, Xiamen, Guiyang, Baoding and Wuhan.He said the ministry will continue to intensify efforts to regulate emissions in the sector to meet the industry's control target during the 12th Five-Year Plan period (2011-2015).In efforts to build a more environmental-friendly society, the government pledged that it will reduce the intensity of carbon dioxide emissions per unit of economic output in 2020 by 40 to 45 percent compared with the level of 2005.

SAN FRANCISCO, Nov. 3 (Xinhua) -- Hewlett-Packard Co. (HP) on Thursday introduced its Slate 2 Tablet PC, a business-targeted tablet computer running Windows operating system.Looking like the previous version, Slate 2, featuring an 8.9- inch screen, is upgraded with Intel Atom Z670 processor to deliver faster boot times and improved battery life up to six hours, said HP.It also has a Bluetooth keyboard dock and Swype keyboard which allows users to enter words by sliding a finger or stylus from letter to letter, lifting only between words.The device will be available to customers worldwide for 699 U.S. dollars later this month, according to HP.Slate 500, Slate 2's previous generation running Windows, was introduced last October and sold exclusively to businesses for 800 dollars upon launch.HP said in a statement that the Slate 2 tablet provides instant deployment for business and vertical markets such as education, healthcare, government and retail, where jobs frequently take users away from a traditional desk.The company on Thursday also announced HP 3115m, a new notebook PC targeting business, education and government customers. The notebook will be available in the Americas only next Friday with prices staring at 429 dollars.HP's consumer-oriented tablet TouchPad was killed off in August before former chief executive officer Leo Apotheker resigned. A dropped price from 499 to 99.99 dollars has made the unpopular device sold out in stores across the U.S. and Canada in days.Last Thursday, HP announced it will keep its PC business, saying it will build tablets running Microsoft's upcoming Windows 8 system in 2012.
CAPE TOWN, Nov. 13 (Xinhua) -- The research vessel SA Agulhas has set off from Cape Town on a 10-day polar tour intended to promote dialogue on climate change, authorities confirmed on Sunday.The trip was designed to mark the 17th Climate Conference of the Parties (COP17) to be held in Durban later this month, according to the Department of Environmental Affairs.The voyage, which set off Saturday noon with scientists, academics, students and journalists aboard, would host exhibitions, symposiums and lectures from climate change scientists on the work of the polar research vessel, spokesman Zolile Nqayi said in a statement.The exhibitions and lectures would also highlight the various scientific activities undertaken by the department and its partners in Antarctica and the Southern Oceans, according to the South African Press Association (SAPA).Apart from her research and supply work, the Agulhus also helped to rescue the Magdalena Oldendorff, which became stuck in thick ice in June 2002.In December the SA Agulhas would make its final voyage to Antarctica before retirement.The Agulhas, which has been in service for 33 years, would be replaced by a new vessel under construction in Finland."She served us very well," said Dr Monde Mayekiso, deputy director general of oceans and coasts."The new vessel will have enhanced technologies and capabilities to further understand the ocean environment and to bring that understanding to an increasing number of South Africans, " he said.
SAN FRANCISCO, Nov. 11 (Xinhua) -- Google will launch its new music service next week, U.S. media reported on Friday.In an emailed invitation, Google said it will hold an event called "These Go to Eleven" next Wednesday in Los Angeles, which is expected to be the debut of Google Music, tech news website The Verge reported.Google is reported to be adding new features over the current version of its music service, such as a MP3 music store with connection to its social network Google+.According to a separate report from technology news site CNET on Friday, Google has not yet got licensing deals with all four of the major labels -- Universal Music Group, Warner Music Group, Sony Music Entertainment and EMI.Google introduced a beta version of its music service called Music Beta in May, enabling users to upload their entire music libraries for free to Google servers and stream songs from any browser or Android-based devices.Since the search giant failed to come to license agreements with major music labels at the time, Music Beta is essentially a massive cloud storage hard drive.
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