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WASHINGTON, Dec. 21 (Xinhua) -- The U.S. Food and Drug Administration (FDA) on Wednesday approved Isentress for the treatment of HIV-1 infection for children and adolescents.The drug is part of a class of medications called HIV integrase strand transfer inhibitors that works by slowing the spread of HIV in the body. It was first approved for use in adult patients in October 2007, under FDA's accelerated approval program."Many young children and adolescents are living with HIV and this approval provides an important additional option for their treatment," said Edward Cox, director of the Office of Antimicrobial Products in the FDA's Center for Drug Evaluation and Research.Isentress is a pill that can be taken twice daily, with or without food. The pill is also available in a chewable form. As the two tablet formulations are not interchangeable, the chewable form is only approved for use in children ages 2 to 11.A single, multi-center clinical trial of 96 children and adolescents aged 2-18 years with HIV-1 infection evaluated the safety and effectiveness of Isentress. These patients previously received treatment for HIV-1 infection. After 24 weeks of treatment with Isentress, 53 percent of these patients had an undetectable amount of HIV in their blood.According to the FDA, the most commonly reported severe, treatment-related side effects in patients taking Isentress include trouble sleeping and headache. The frequency of these side effects is similar for children and adults. One pediatric patient reported severe treatment-related insomnia, while another pediatric patient experienced a drug-related skin rash.
BEIJING, Oct. 20 (Xinhuanet) -- British scientists used bacteria and DNA to build basic components for digital devices in a new research, according to media reports, suggesting biological computers come closer to reality.Digital devices are based on logic gates, fundamental building blocks in silicon circuitry, said Professor Richard Kitney, leading researcher of the research published in the journal Nature Communications, "Without them, we could not process digital information."According to Science Daily, Professor Kitney and his colleagues from the Imperial College London replicated the building blocks using bacteria and DNA, forming biological logic gates, which paved the way for building more complex biological processors in the future.The researchers hoped biological computers can be applied to monitoring human health in the future.They believed that small biological processors, inserted in human bodies, could roam inside the bodies, monitor the health, and correct any problems they found.These biological logic gates are the most advanced created by scientists. But there is still a long way to go to apply them in reality, said Professor Kitney.

WASHINGTON, Dec. 28 (Xinhua) -- People with diets high in several vitamins or in omega 3 fatty acids are less likely to have the brain shrinkage associated with Alzheimer's disease than people whose diets are not high in those nutrients, according to a new study published on Wednesday in the online issue of Neurology, the medical journal of the American Academy of Neurology.Those with diets high in omega 3 fatty acids and in vitamins C, D, E and the B vitamins also had higher scores on mental thinking tests than people with diets low in those nutrients. These omega 3 fatty acids and vitamin D are primarily found in fish. The B vitamins and antioxidants C and E are primarily found in fruits and vegetables.In another finding, the study showed that people with diets high in trans fats were more likely to have brain shrinkage and lower scores on the thinking and memory tests than people with diets low in trans fats. Trans fats are primarily found in packaged, fast, fried and frozen food, baked goods and margarine spreads.The study involved 104 people with an average age of 87 and very few risk factors for memory and thinking problems. Blood tests were used to determine the levels of various nutrients present in the blood of each participant. All of the participants also took tests of their memory and thinking skills. A total of 42 of the participants had MRI scans to measure their brain volume. Overall, the participants had good nutritional status, but seven percent were deficient in vitamin B12 and 25 percent were deficient in vitamin D.Study author Gene Bowman, of Oregon Health & Science University in Portland, said that the nutrient biomarkers in the blood accounted for a significant amount of the variation in both brain volume and thinking and memory scores. For the thinking and memory scores, the nutrient biomarkers accounted for 17 percent of the variation in the scores. For brain volume, the nutrient biomarkers accounted for 37 percent of the variation."These results need to be confirmed, but obviously it is very exciting to think that people could potentially stop their brains from shrinking and keep them sharp by adjusting their diet," Bowman said.
SAN FRANCISCO, Oct. 7 (Xinhua) -- The funeral for Apple co-founder Steve Jobs, who died Wednesday at the age of 56, is taking place on Friday, U.S. media reported.The funeral is termed as a small private gathering, The Wall Street Journal quoted a person familiar with the matter as saying.The source would not disclose where or when the event was taking place, citing respect for Jobs and his family's privacy.Apple said it has no public services planned for Jobs. In an e- mail sent to Apple staff on Wednesday, Chief Executive Officer Tim Cook said "a celebration of Steve's extraordinary life" would be held soon for employees.On its website, Apple has encouraged people to send their memories and condolence to a special e-mail address.Meanwhile, online magazine deadling.com reported Friday that Sony Pictures is making a hefty deal to acquire feature rights to "Steve Jobs," the only authorized biography of the Apple co- founder which will be published on Oct. 24.
BEIJING, Nov. 30 (Xinhuanet) -- Heading football frequently may cause brain damage leading to subtle but serious declines in thinking and coordination skills, a new study suggested as quoted by media reports Wednesday.Researchers used an advanced MRI (Magnetic Resonance Imaging) technique to analyze changes in brain white matter of 32 adult amateur soccer players who head balls 436 times a year on average.The study found players who head football quite frequently -- with 1,000 or more a year -- showed abnormalities similar to traumatic brain injuries suffered in car accidents."This is the first study to look at the effects of heading on the brain using sophisticated diffusion tensor imaging," said Dr. Michael Lipton, a leading researcher and associate director of the Gruss Magnetic Resonance Research Center at the Albert Einstein College of Medicine in New York City."We found the real implication for players isn't from hitting headers once in a while, but repetitively, which can lead to degeneration of brain cells," he added.The researchers compared neurological images of study participants, whose average age was 31, and found those with the highest volume of headers had abnormalities in five areas of the brain, responsible for attention, memory, physical mobility and high-level visual functions.The findings come in the wake of mixed reports on the so-called "cognitive" consequences of frequently heading soccer balls at practice.Dr. Chris Koutures, a pediatrician and sports medicine specialist in Anaheim Hills, California, said the retrospective imaging study was fascinating, but needs more data to effectively determine safe header limits, especially for younger players.Dr. Lipton agreed neuropsychological damage from headers would be hard for a coach or physician to notice since cognitive problems develop gradually, and even players might not be aware of mild memory loss."We can't tell an individual today not to be heading a ball, but caution is a good thing," Lipton said. "We need more research for definitive answers and we have the advanced imaging tools to do it."
来源:资阳报