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WASHINGTON, Nov. 7 (Xinhua) -- U.S. researchers have demonstrated for the first time that the brain is a key player in regulating glucose (sugar) metabolism in humans.The findings, published Monday in the online edition of the Journal of Clinical Investigation, suggest that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes."The brain is the body's only organ that needs a constant supply of glucose to survive, so it makes sense that it would have some say over how much glucose is produced," said study leader Meredith Hawkins, professor of medicine and director of the Global Diabetes Initiative at Yeshiva University, in a statement. "This role for the brain was demonstrated in earlier studies in rodents, but there was considerable controversy over whether the results could be applied to humans. We hope this study helps to settle the matter."In an earlier study in rodents, researchers showed that activation of potassium channels in the brain's hypothalamus sends signals to the liver that dampen its production of glucose. Those findings, published in Nature in 2005, challenged the conventional thinking that blood sugar production by the liver (the body's glucose factory) is regulated only by the pancreas (which makes insulin to metabolize glucose). But carefully performed studies on dogs, conducted at Vanderbilt University, failed to replicate the results, suggesting the Einstein findings in rodents might not be relevant to higher mammals, including humans.The current study, involving people, was aimed at resolving this controversy. Ten nondiabetic subjects were given oral diazoxide, a drug that activates potassium channels in the hypothalamus. (The drug is not used to treat diabetes.) Hormone secretion by the pancreas was controlled to ensure that any change in sugar production would only have occurred through the drug's effect on the brain. After the researchers administered the drug, blood tests revealed that patients' livers were producing significantly less glucose than before.Hawkins and her team then repeated this in rats, again giving diazoxide orally, achieving similar results. They confirmed that sufficient amounts of diazoxide crossed the blood-brain barrier to affect potassium channels in the hypothalamus. Additional experiments confirmed that diazoxide was working through the brain. Specifically, the researchers were able to completely block the effects of diazoxide by infusing a specific potassium channel blocker directly into the brain."This study confirms that the brain plays a significant role in regulating glucose production by the liver," said lead author Preeti Kishore, assistant professor of medicine. "We are now investigating whether this 'brain-to-liver' pathway is impaired in people with diabetes. If so, we may be able to restore normal glucose regulation by targeting potassium channels in the brain."

WASHINGTON, Oct. 3 (Xinhua) -- The Rockefeller University confirmed Monday its Canadian-born cell biologist Ralph Steinman died three days before being awarded the Nobel Prize on Monday as the Nobel committee was unaware of his death at the time."Steinman passed away on September 30," the New York university said in a statement."He was diagnosed with pancreatic cancer four years ago, and his life was extended using a dendritic-cell based immunotherapy of his own design."The Nobel committee was unaware of Steinman's death when announcing this year's winners and it was unclear whether the prize would be rescinded because Nobel statutes don't allow posthumous award."The Rockefeller University is delighted that the Nobel Foundation has recognized Ralph Steinman for his seminal discoveries concerning the body's immune responses," says Rockefeller University President Marc Tessier-Lavigne."But the news is bittersweet, as we also learned this morning from Ralph's family that he passed a few days ago after a long battle with cancer. Our thoughts are with Ralph's wife, children and family.""We are all so touched that our father's many years of hard work are being recognized with a Nobel Prize," says Steinman's daughter Alexis. "He devoted his life to his work and his family, and he would be truly honored.""Ralph's research has laid the foundation for numerous discoveries in the critically important field of immunology, and it has led to innovative new approaches in how we treat cancer, infectious diseases and disorders of the immune system," Tessier-Lavigne says.Steinman, who discovered the immune system's sentinel dendritic cells, is this year's recipient of the Nobel Prize in Physiology or Medicine. He shares half the prize with Bruce Beutler and Jules Hoffmann.

ADDIS ABABA, Nov. 2 (Xinhua) -- Ethiopia will host the 13th World Congress on Public Health (WCPH) in April 2012, the Ethiopian Public Health Association (EPHA) said on Wednesday.The meeting will be held on April 23-27 under the theme: "Moving towards Global Health Equity- Opportunities and Treats".Speaking on the 22nd annual meeting of EPHA held here on Wednesday EPHA President Tewabech Bishaw said about 3,000 participants, including public health students from all over the world are expected to take part in the meeting.He said that preparations are well underway to successfully conduct the meeting.

MILAN, Italy, Dec. 1 (Xinhua) -- Italy has a new HIV infection every three hours on average, the national department of health said in a statement during the World AIDS Day commemoration Thursday.According to the statement, there were about 3,000 new infections in the country in 2010, with nearly one third of those affecting a foreigner.At least 157,000 people are presently estimated to be HIV-positive in Italy, though the country's AIDS infections and deaths continue to register a negative trend.Nearly 90 percent of the new patients acquired the virus through unprotected sex, and were mostly from the northern regions.People discovered to be HIV-positive in 2010 had an average age of 39 for men and 35 for women, more than a third of whom were diagnosed at an advanced stage of the disease, the statement said.Misinformation and a lack of preventive measures are a great cause for concern, Milan's councillor for social services and health Pierfrancesco Majorino told Xinhua at a campaign launched in Milan's La Scala Square."We have to keep in mind that AIDS is something very close to each of us, and adopt all most effective campaigns to provide complete and correct information," he said.A red ribbon -- the international symbol of AIDS awareness -- was formed by a group of people at the center of the square to remind everyone to stay alert to the disease.On World AIDS Day, disease prevention and health information campaigns were launched throughout Italy, including free ultra-rapid HIV-screening tests.

ADDIS ABABA, Dec. 1 (Xinhua) -- Marking the World AIDS Day on Thursday at the African Union (AU) headquarters in Addis Ababa, Ethiopia, Jean Ping, the AU Commission chairperson, said Africa should no longer see new generations with HIV infection.Through his representative, Ping called upon individual and collective action to contain mother to child transmission of HIV."We should act individually and collectively not only to prevent mother to child transmission but also to take care of the health of people living with the virus," said the chairperson.He also expressed commitment of the AU Commission to work with member states and pertinent bodies in the efforts made to HIV treatment and prevention.The World AIDS Day is commemorated this year under the theme "Zero Mother to Child Transmission", as world leaders who were gathered in New York for the 2011 United Nations (UN) High Level Meeting on AIDS in June, launched a Global Plan for significant strides towards eliminating new HIV infection among children by 2015 and keeping their mothers alive.Remarkable progress has been made so far, which is proof to realize the vision of zero new HIV infection, zero discrimination, and zero AIDS-related death (the three zeros), said UN Secretary General Ban Ki-moon in the message on the commemoration of the World AIDS Day.The secretary general revealed that the number of new infections has fallen by more than 20 percent since 1997, and new infections are continuing to decline in most parts of the world.In sub-Saharan Africa, the region most affected by the AIDS epidemic, HIV incidence has decreased in 22 countries, he said.According to UNAIDS, Ethiopia, Nigeria, South Africa, Zambia, and Zimbabwe are among the African countries where new HIV infections dropped significantly."Treatment has averted 2.5 million AIDS-related deaths since 1985. Last year alone, 700,000 lives were saved. Some 6.6 million people, nearly half those who need treatment in low and middle- income countries, are now receiving it," said Ban."Synergies between prevention and treatment are speeding up progress. But, to end AIDS, we need to deliver even greater results," said the secretary general.The UNAIDS says to get to the three zeros there must be acceleration on smart investments, capitalizing on scientific advancements and respecting human rights.Speaking at the AU headquarters on the commemoration of AIDS Day, Jan Beagle, deputy executive director of UNAIDS, underlined on the need to invest smartly to achieve the vision of the three zeros.There is a global target of 22 million U. S. dollars to 24 billion dollars to fund the AIDS response, which the UNAIDS says is a shared responsibility of all countries, donors and others."International assistance for the AIDS response has declined from 8.7 billion dollars in 2009 to 7.6 billion in 2010," said the Deputy Executive Director."We need to use new technology more effectively to reduce costs and demonstrate that we can deliver return on investment," she said.The AIDS movement is a movement for inclusiveness, equity and social justice, she said, adding that it has demonstrated global solidarity is possible to address multi-sectoral challenges.According to Abdoulie Janneh, executive secretary of the UN Economic Commission for Africa (ECA), an estimated 7,000 people get infected with HIV infections every day.The executive secretary highlighted ingenious and novel approaches in introducing new HIV/AIDS prevention strategies."A combination of the traditional initiatives and innovative initiatives can all be used to eliminate new HIV infections," said Janneh.