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JUPITER, Fla. — Groundbreaking research out of the Scripps Research Institute in Jupiter, Florida found a genetic explanation for the pain processing and sensory issues some children living with autism face."To see the biology in the lab turn out that has parallels to what’s going on in these children takes it so far beyond just an academic endeavor," said Dr. Gavin Rumbaugh, a neuroscientist at Scripps. "You go home every day thinking, unbelievably, I may actually be making a difference in someone's life."One of those children who Rumbaugh hopes to help with his research is 10-year-old Beckett, who lives in Texas."We wanted to understand generally in the lab how genes like SYNGAP1 affect the way the brain functions and we thought what better way was then to look and see how this gene may directly affect sensory processing, and then further on ask the question, 'Does the change in sensory processing actually lead directly to learning, memory and behavioral impairment?' " he said.Beckett has a genetic mutation of SYNGAP1, which researchers have now found causes certain issues he faces, particularly, having an extremely high pain threshold while also experiencing heightened sensitivity to another kind of stimuli. Beckett and other children living with this genetic mutation also often have epilepsy."It's all about quality of life. Everybody deserves to live their best life and that's my mission," said Monica Weldon, Beckett's mom.Weldon said the research being done in Jupiter could change her son's life and the lives of hundreds of other children around the world with the same genetic abnormality and symptoms, some of whom whose families she's connected with online."That is the power I believe of a patient group that is motivated to find treatments for their loved ones," Weldon said. "Also, you've got scientists who are listening. They're willing to listen and they're willing to learn."The next step in Rumbaugh's research is to look at treating the symptoms from the genetic mutation. 2043

Jill Biden wraps a day of the campaign on behalf of her husband, Joe with a Minnesota "Women for Biden Get Out The Vote" Rally in Minneapolis. WATCH RECAP:Jill Biden was joined by Minnesota Lt. Gov. Peggy Flanagan, US Senator Tina Smith, and several other female candidates for local and statewide offices. 314

JAMUL, Calif. (KGTV) - Anabel and Dewey will celebrate 21 years of marriage this year, but in the smallest fraction of that time, everything from their life was destroyed.The couple lived in their Jamul home with Anabel’s mother and their five cats. Saturday, Anabel was at work and her mother was out of town. Dewey saw there was a fire in the distance, but felt confident it would be contained quickly, like most of the fires that spark in their area. He left the home, not knowing it would be the last time he saw it standing.That night, flames engulfed their home. Video captured shows it on fire, with firefighters nearby trying to find the flames, but they were unsuccessful. The five cats were not able to be saved.RELATED COVERAGEVALLEY FIRE: Resources on where to get help, air quality, and animal sheltersINTERACTIVE MAP: Valley Fire erupts in Japatul Valley areaPhotos: Valley Fire erupts in East CountyAnabel said they have not been able to return home to see the damage, and found out about the loss from images online, a realization that was hard to process.“But the more I looked at it, that was our house. That was the car, my mom’s car, right by the house that was on fire,” she said.In the fire, they lost their cats and a lifetime of memorabilia. At home, they had many family members' ashes, including Dewey’s mother, Anabel’s stepfather and also Anabel’s son, who passed away from cancer this year.Also lost were sentimental items from Dewey’s 22 years in the Navy, including his shadow box and his uniform, which he intended to wear when he pinned his mentees, an honor in the military community.RELATED COVERAGE:Red Cross evacuation sites provide outdoor shelter and hotel lodging amid pandemicABC 10News forecast for San Diego County“They’ve asked to make sure that I pin them. And you can buy a new uniform, yeah, but you’d like to wear the one you wore,” he said, holding back tears.Despite the long list of losses, the couple said they aren’t giving up.“It’s just [beginning] again, it’s not the end and that’s the way it’s going to be,” said Dewey.Their nephew started a GoFundMe to help them get back on their feet. They said the support from friends and strangers already has touched them in ways they didn’t know were possible.“We are overwhelmed. I don’t know what the proper adjective is or the expression to explain the level of which we are thankful to so many friends, family and strangers who are being extremely generous,” said Dewey. 2480

JULIAN (CNS) - A motorcyclist was killed in a crash near Julian on Saturday.California Highway Patrol officers headed to state Route 79 near Sunrise Highway about 1:50 p.m. for a report that a Toyota 4Runner had struck a motorcycle and pinned the rider underneath the vehicle, according to a CHP incident log.The motorcyclist was pronounced dead at the scene, according to Cal Fire San Diego. No identifying information on the victim was available.One-way traffic control was in place while authorities investigated and worked to clean up the crash, according to the CHP. 579

Kamala Harris is projected to become the first female Vice President of the United States. She will also be the first Black and first South Asian to hold that office. Her husband, Doug Emhoff, will set his own historic precedent.Emhoff will become the first second gentleman of the country when Harris is sworn in. The spouse of the vice president is typically called the “second lady”, and Emhoff is the first male spouse in the country’s history.Harris’ spouse is an entertainment lawyer and partner at the firm DLA Piper, and has been for the last few years. He took a leave of absence after Harris joined Biden’s ticket so he could focus on the campaign trail, he said at the time.Saturday morning, Emhoff tweeted a picture of him hugging Harris saying, “So proud of you.” 784

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