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SAN DIEGO (KGTV) - Anyone touched by Alzheimer's knows how painful the disease is. "It's affected my family. It's affected most families. It's such a prevalent disease. As people get older, it becomes quite likely this will become an issue," said Paul Aisen, director of USC's Alzheimer's Therapeutic Research Clinic (ACTC).Aisen's team began their research in San Diego many years ago and teamed up with USC about four years ago. He's spent over 30 years trying to solve Alzheimer's mysteries and is leading the upcoming clinical trial.Aisen says the large-scale study is the culmination of decades of work from scientists worldwide."Our focus lately has been trying to alter the disease, prevent it, or significantly slow its progression. How should we do that? We think attacking amyloid early is the most promising approach," said Aisen. Researchers believe sticky amyloid deposits, which form on the brain later in life, start the Alzheimer's process. Aging, genetics, and lifestyle factors can all contribute to amyloid build-up.The worldwide clinical trial aims to target amyloid. A drug called BAN2401 will be delivered intravenously, designed to bind to the sticky amyloid. The binding neutralizes beta amyloid and helps "tag" it, so the immune system can recognize it and clear it from the brain. A previous phase 2 study showed that BAN2401 removes brain amyloid and possibly slows cognitive decline.They're seeking participants over 50 who are not yet showing symptoms of Alzheimer's but do have elevated amounts of amyloid on their brain. Researchers can determine that through a PET scan or spinal tap. "We think that the most promising approach of all is to take a vigorous attack on amyloid while the brain is still functioning normally. And we can see amyloid in people many years before they develop the symptoms of Alzheimer's."Investigators hope that by treating a patient with BAN2401 very early in the disease, before symptoms occur, it will significantly slow disease progression. "If we're successful, it will have a huge impact on human health," said Aisen. There will be 100 sites worldwide for the study, including major cities like San Diego and Los Angeles. Study participants will receive treatment for four years, given either the drug or a placebo. Results are expected in seven years, Aisen says. If you or a loved one wants to participate, learn more here.Screening will officially begin in May. 2438
SAN DIEGO (KGTV) - Candalee Carbonel remembers the panic she felt Tuesday when her son's principal called about an incident involving her 7-year-old. "This is a horrible situation, I pray no other family has to go through this," said Carbonel. Her son Cole has autism and managed to walk off the Miller Elementary campus in Tierrasanta without staff noticing. He walked about half a mile to his house. "It broke my heart, knowing I drop off my child every day at school in their hands. They are now responsible to be his safety, to keep him out of danger. This really breaks my heart," said Carbonel. Carbonel says panic turned to frustration when she learned how the school handled the situation. "They should've called 911, called the police, then called me, and I could've helped. I could've been somewhere; I could've come home, I could've been here for my son when he was looking for me," said Carbonel. But instead, the principal went to look for Cole herself, driving to the family's home. She found Cole inside the house, watching television on the couch, and proceeded to take him back to the school and call Carbonel. "It broke my heart that a little kid could be running the streets, and no one called his mom," said Carbonel. She's grateful he made it home safe, but Carbonel says she can't help but wonder what could have happened to him on the walk home. The military family is new to the district, and Carbonel says she's been advocating for her son to have a one-on-one aide as he did in his last school district. She was pushing for more support for her son so that an incident like this wouldn't happen. SDUSD says as a result of this incident, they are going to add an additional staff member to provide above-and-beyond support to Cole's classroom. They also plan to schedule an Individualized Education Program (IEP) review to reassess his needs.Miller Elementary's principal provided 10News the following statement: 1945

SAN DIEGO (KGTV) — Boulevard Fitness in University Heights has closed its doors following a letter from the city threatening expensive fines and to force the business to close.The gym stayed open in the face of local coronavirus-related restrictions on indoor activities for fitness centers for more than a month, according to a letter from City Attorney Mara Elliott."To date, evidence we have reviewed shows your business has been out of compliance for more than 45 days. If our office chooses to remedy the violation by pursuing an unfair business practices action, you and your business could be subject to fines of ,500 a day for each violation and orders to close," Elliott's letter on Tuesday stated.RELATED: Businesses to begin outdoor services at San Diego parksIn a letter sent to the gym's members on Wednesday, Boulevard Fitness said it has temporarily closed "due to current fiscal situations.""We are not sure when this closure period will end but we will be [sic] continuously monitor this and update you when appropriate," the gym's letter read. "However, we are working closely with our legal counsel to get in compliance with public health orders so that we can open up again soon."Boulevard Fitness owner Shawn Gilbert told ABC 10News back in July that staying open is a matter of survival."I took a huge financial hit in May. Money out of my pocket that's never coming back. We have bills to pay, we have rent to pay,” Gilbert told ABC 10News. He added that he believed his gym can operate indoors safely with face coverings and distancing, and that he has an outdoor area he plans to utilize.The gym on El Cajon Boulevard had been limiting the number of people inside and increasing cleaning and other measures to try to limit the risk of spreading the virus.RELATED: North Park gym forced to move outside, immediately finds syringeThis month, ABC 10News analyzed data from 211 revealed the gym was among businesses that have received the most complaints from the public about health order violations, with 141 complaints at the time.In a follow-up to ABC 10News, Elliott said the gym was contacted several times by San Diego Police officers and given warnings and citations by the county. This is reportedly the first case of its kind referred to the City Attorney's office."For more than a month, Boulevard Fitness ignored the county's orders to stop endangering the health of its members and the public. My office stepped in and got quick compliance the same way we did with the Banker's Hill party house -- by laying out the fines and penalties we could seek if they continued breaking the law, " Elliott said. "The spread of COVID is a problem that my office takes seriously."San Diego County officials are still awaiting guidance on reopening from the state after the region was removed from the California Monitoring List last week. 2870
SAN DIEGO (KGTV) - Crews were quick to knock down a fire along a San Diego freeway late Friday.Video showed captured at the scene show a tree engulfed in flames along the westbound side of State Route 94 near northbound Interstate 5 at about 6:30 p.m.It's not clear how the fire began, but crews were quick to douse the flames.10NEWS?UPDATING TRAFFIC CONDITIONSNo injuries have been reported. Traffic did not seem largely affected by the sudden fire. 458
SAN DIEGO (KGTV) — Authorities are looking for an inmate who walked away from a San Diego rehabilitation facility.Steven Vargas, 53, was last seen at 10 a.m. Tuesday after leaving the San Diego's Male Community Reentry Program, according to the California Department of Corrections and Rehabilitation. Vargas had been given permission to leave the facility but didn't return when required.The facility allows eligible offenders with one year left to serve to do so in re-entry centers, providing them with rehabilitation services that assist them with substance use disorders, mental health care, employment, education, housing, and more. Officials said they were alerted that Vargas' electronic monitoring device had been tampered with just before noon Tuesday.Vargas was sentenced to four years in prison on May 6, 2019 for vehicle theft with prior vehicle related theft convictions and grand theft of a firearm. He was scheduled to be released on parole in June.Vargas is described as a Hispanic male, 6-feet tall, and weighs about 192 pounds. He was last seen wearing faded black jeans, black shoes, a blue shirt, and a charcoal grey sweater. He also has a long gray and white goatee.Anyone with information on Vargas' whereabouts is asked to call 911 immediately. 1276
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