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SAN DIEGO (KGTV) — The National Institutes of Health highlighted research Tuesday out of UC San Diego that could unlock a new way to treat COVID-19.The research reveals new insight into how the coronavirus hijacks cells, and how doctors might be able to set traps or decoys to combat the virus. The findings were published in the journal Cell last month.“It does open up another avenue for a potential treatment,” said UC San Diego distinguished professor Dr. Jeffrey Esko. “It’s not a cure. It would be something that would tamp down infection potentially.”Since January, scientists around the world have understood that SARS-Co-V2, the official name of the new coronavirus, enters cells by latching onto a specific receptor on the cell’s surface, called ACE2.The UCSD team, led by Dr. Esko and visiting scholar Dr. Thomas Clausen, discovered that this entry mechanism is actually a two-step process, and the virus must also attach to a long chain of sugars called heparan sulfate.“We’ve shown this is fundamental to the infectious mechanism, so it needs to be part of every study from now on,” said Clausen.All cells are coated with a complex layer of sugars, or carbohydrates, called glycans. Heparan sulfate is one type of glycan that is known to play a key role in the infection process in several viruses, including herpes and other coronaviruses.It’s a complicated process to picture so the researchers offer an analogy: imagine a bird, soaring over trees, hunting a worm on the forest floor. The bird is the coronavirus and the trees are the thick layer of glycans that coat the surface of the cell.To reach the worm, which in this case is the receptor ACE2, the bird must navigate its way through the trees, specifically through heparan sulfate.The UCSD found that by removing the heparan sulfate trees with an enzyme, they were able to prevent the virus from infecting cells. In laboratory testing, they also found a second technique worked to foil the virus: introducing more trees as bait.The team found that heparin, an FDA-approved drug that is similar in structure to heparan sulfate, successfully acted as decoy. Heparin is a widely used drug designed to treat blood clots. Since blood clots and strokes are common complications with COVID-19, many doctors already administer heparin to patients.The UCSD team demonstrated that the two approaches can block infection in lab-grown cells about 80 to 90 percent of the time.“Certainly in the laboratory you can demonstrate that it works, but to deploy it and use it as a therapeutic has not been demonstrated,” Esko said.The NIH noted that more studies are planned to explore whether heparin, heparan sulfate, or drugs that target heparan sulfate might yield a viable COVID-19 treatment.Dr. Esko said he’s already been in talks with companies that plan to use their study as a rationale for a clinical trial.“It is very humbling when you realize we’re working on a pandemic right now, and maybe what we’ve done can contribute to a treatment for the disease,” he said. 3038

SAN DIEGO (KGTV) -- The National Weather Service is warning beachgoers ahead of the July 4 holiday about elevated surf and strong rip currents. A beach hazards statement will remain in effect until Friday at 3 a.m. According to the National Weather Service, waves will reach three to six feet accompanied by dangerous rip currents. “Remember to swim near a lifeguard if going out in the ocean,” said 10News meteorologist Megan Parry. RELATED: Check your Fourth of July forecastTidal overflow is also possible is areas prone to flooding, such as low-lying areas. “Tidal overflow will be possible in low lying areas during high tide between 9pm and midnight each night - keep that in mind when setting up to watch any fireworks shows during the day as the high tide moves in it may push you back by the night,” Parry added. Swells are expected to build again Friday through Sunday from Hurricane Barbara. 911

SAN DIEGO (KGTV) -- The next time you hop in your car and drive through North Park, you could encounter one of 18 new traffic circles aimed to slow down drivers and promote caution and awareness. The executive director of SANGAG, Hasan Ikhrata, spoke Wednesday about the status of 18 intersection makeovers that include roundabouts similar one off Landis and Utah."It's obvious cars and bikes don't mix well together, especially if there's speeding involved so to overcome these we try our best to do things like this, but also make sure where we can, separate bikes from traffic so residents can bike without fear of being hit by a car," Ikhrata said.So far, million has been dropped for the Georgia Meade & Landis Bikeway project, funded by TransNet. Construction for the new additions are halfway done and although some neighbors aren't so keen about the new roadways, "people who want to go fast do go fast still, they still race. They have enough room to almost go straight through the circle." Others like 11-year North Park resident, Andrea, Linan, already feel more at ease, "traffic on this street especially, people go fast. I do cycling and you just have to be really careful about not getting hit so I don't mind roundabouts."SANDAG said since stay at home orders, the amount of people riding bikes went up 12%. SANDAG's executive director said despite conflicting arguments regarding the amount spent on the Bikeway project, "we have the data to support investing more in the Bikeway program, and I hope San Diego will have a connected network that's safe for our residents."The project has been in the works since 2013. SANDAG said the process included community meetings, public workshops and hearings so neighbors can chime in. 1760

SAN DIEGO (KGTV) — The county Medical Examiner has identified the second teenager killed after a car lost control on a Mission Valley freeway and crashed before bursting into flames last weekend.David Chavez, 15, was killed by blunt force trauma, thermal cause, and smoke inhalation according to the ME in the tragic crash on Jan. 18.Police say a car was speeding at about 3 a.m. on the westbound Interstate 8 ramp to southbound State Route 163 when the driver lost control and hit a guardrail, sending the car down an embankment where it a tree and caught fire.RELATED:Community helping family of teen killed in Mission Valley crashAt least 2 dead in fiery freeway crash in Mission ValleyAnother 15-year-old, identified as Gustavo Beltran, was also killed in the crash.The driver, a 17-year-old, was arrested by CHP on suspicion of DUI. Two other teens in the car are also battling significant injuries. None of their identities have been released by authorities. 972

SAN DIEGO (KGTV) — The alarm blares in your ears, as your eye lids slowly peak open and usher in a flood of sunlight. You drag your feet along the floor to the kitchen, where a device that has saved mornings for so many awaits you.Coffee is often regarded as a necessity to begin the day, but sometimes it's just what the doctor ordered for a relaxing day. In San Diego, several local coffee roasters and houses blend together their unique coffee recipes that can both kickstart your day or provide a warm moment of solace.And as National Coffee Day comes on Sept. 29 this year — a Sunday — there's no better time to wake and relax at a coffee house before the work week kicks into gear. While you're out and about, be sure to duck into one of San Diego's many coffee houses to sample their invigorating drinks:Bird Rock Coffee Roasters (Locations in La Jolla, Bressi Ranch, Little Italy, Torrey Pines, Morena, Pacific Beach): Bird Rock boasts high-quality coffee, their own signature mixes, and seasonal blends of delicious coffees at their locations around town.Better Buzz (Locations in La Jolla, Pacific Beach, Hillcrest, Encinitas, Fashion Valley, Point Loma, Mission Beach, San Marcos): In addition to their signature drinks like "Best Drink Ever" and "Hazelnut Divinity," Better Buzz offers delicious cold brews, mochas and lattes, and eats to match.Dark Horse Coffee Roasters (Locations in Normal Heights, North Park, Golden Hill, La Mesa): Head over to Dark Horse Coffee Roasters for their signature Espresso drinks, like “The Champ” or cold brew on nitro with a splash of vanilla bean syrup.Lofty Coffee & Bakery (Locations in Solana Beach, Encinitas, Little Italy): Lofty Coffee roasts its own beans and crafts pastries from scratch at hubs along San Diego's coastal communities.Jennings House Cafe: One of San Diego's oldest coffee brands, Jennings House Cafe serves up Cura Coffee and delicious breakfast dishes in a historic landmark home dating back to 1886.The WestBean Coffee Roasters (Locations in downtown, Liberty Station, Bankers Hill): WestBean sources its own beans, churning out some delicious espressos and refreshing cold brews.James Coffee Co. (Locations in Little Italy, Bankers Hill, downtown, Columbia): James Coffee Co. puts together your traditional brews plus some delicious specialty drinks with honey cinnamon, Mexican mocha, or coffee soda.Philz Coffee (Locations in La Jolla, Del Mar, Encinitas): The Bay Area brings specialty beans — 28 types of beans, in fact — involving a variety of flavors like grapefruit, Cherry, maple, and others.Refill: Refill packs its java house with all the needed brews: Mochas, lattes, cappuccinos, and some delicious cold brew concoctions and crepes.Modern Times: In Modern Times' Lomaland Fermentorium, the brewery roasts its own beans in a modest roaster beside taps of its brews. And of course, so of those beans have crossed over to combine barrel-aged beans.Heartwork: San Diegans have long been fans of Heartwork's brews using James Coffee Co. and Dark Horse roasted beans.Moniker Coffee Co.: A variety of small-batch coffee from local producers and some out-of-town roasters can be found at Moniker's Liberty Station stop.Communal Coffee (Locations in South Park, North Park): Grab a cup of coffee and flowers on the side! Communal Coffee, which serves Sightglass Coffee from San Francisco. Expect some creative drinks like rose vanilla, taro, and sea salt and caramel coffees.Revolution Roasters (Location in Oceanside): Fresh-baked pasteries, breakfast dishes, and of course, an awakening variety of coffees awaits at Revolution Roasters, including their signature Lavender Honey and Butterscotch lattes.SkyBound Coffee + Dessert Lounge (Locations in Vista, Downtown San Diego): Whether you want your coffee hot or cold, SkyBound has what you need with their Skybound Dark Chocolate Mocha, iced lavender vanilla, sea salt, or VanillaCali coffees.Perks Coffee House (Location in San Marcos): Delicious cold brew on tap, freshly roasted beans, and a variety of Espresso drinks will surely perk your senses at Perks Coffee House. Keep an eye on their seasonal Cafe Viennese, Dirty Chai latte or go for something a little harder like Irish Coffee. 4234