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WASHINGTON, Oct. 3 (Xinhua) -- Overweight or obesity may put children at three times greater risk for high blood pressure than those of normal weight, according to researchers from the Regenstrief Institute and Indiana University (IU) School of Medicine.Their study will appear in the November issue of Hypertension: Journal of the American Heart Association with advance online publication on Monday.More than 1,100 healthy Indiana school children were followed for nearly five years. The researchers found that when body mass index (BMI) reached or exceeded the 85th percentile for the age and gender of the child -- designated as being overweight -- the risk of high blood pressure nearly tripled. Obesity was defined as a BMI percentile higher than 95th. BMI is a measurement of body fat calculated from weight and height.Among study participants, 14 percent of overweight or obese children were pre-hypertensive or hypertensive, compared with 5 percent of normal weight children. These findings were consistent across age, gender and race.The average age at time of study enrollment was 10.2 years. Each child was assessed approximately eight times during the course of the study. All were healthy children and none were taking medication affecting blood pressure."Higher blood pressure in childhood sets the stage for high blood pressure in adulthood," said Regenstrief Institute Investigator Wanzhu Tu, professor of biostatistics at IU School of Medicine, who led the study. "Targeted interventions are needed for these children. Even small decreases in BMI could yield major health benefits."The researcher also found that leptin, a protein hormone which is involved in body weight regulation and metabolism, was positively associated with increased blood pressure in overweight and obese children.

WASHINGTON, Oct. 3 (Xinhua) -- Researchers at St. Michael's Hospital in Canada have discovered a new function for an enzyme that may protect against organ injury and death from anemia, according to a study appearing Monday in the U.S. journal of the Proceeding of the National Academy of Sciences.Researchers found that when people have anemia, neuronal nitric oxide synthase (nNOS) -- an enzyme in nerve cells that produces nitric oxide, an important signaling molecule in the body -- increases the body's ability to respond, adapt to low oxygen levels and makes the body more efficient in delivering oxygen to tissues. They also found that levels of nNOS in the brain increased in anemic mice, and that the mice without this enzyme die earlier, and with higher hemoglobin levels."Identifying this mechanism may lead to new therapies and approaches to improving outcomes for anemic patients," said Dr. Greg Hare, a researcher at the Li Ka Shing Knowledge Institute of the hospital and one of the lead investigators of the study.Anemia occurs when blood has a lower than normal number of red blood cells or hemoglobin -- an iron-rich protein that carries oxygen from the lungs and heart to the rest of the body. Cells need oxygen to survive and to produce energy for all bodily functions. The condition has many different causes including infection (malaria, HIV, parasites), nutritional deficiencies (iron, folate, B12), genetic mutations, pregnancy, trauma and surgical blood loss."This research will help us identify when an anemic patient is at greatest risk for injury and death when undergoing surgery," said Hare. "Research is underway to test these findings in humans."

SAN FRANCISCO, Dec. 2 (Xinhua) -- Only two weeks after its shipment, Amazon's Kindle Fire has already shown the momentum to grab the second place in global tablet computer market, research firm IHS predicted on Friday.Amazon is expected to ship 3.9 million Kindle Fire tablets during the last three months of 2011, the first quarter the product goes on sale, according to preliminary projection from IHS.The number will give Amazon a 13.8-percent share of global tablet market in the fourth quarter, surpassing the 4.8 percent held by No. 3 player Samsung, and second only to Apple's commanding 65.6 percent market share."Nearly two years after Apple Inc. rolled out the iPad, a competitor has finally developed an alternative which looks like it might have enough of Apple's secret sauce to succeed," Rhoda Alexander, senior manager of tablet and monitor research for IHS, said in a statement."Initial market response strongly suggests that Amazon, with the Kindle Fire, has found the right combination of savvy pricing, astute marketing, accessible content and an appropriate business model, positioning the Kindle Fire to appeal to a brand-new set of media tablet buyers," she added.IHS analysts noted that with a price tag of 199 U.S. dollars, the Kindle Fire has set a new bar for pricing, bringing the tablet within reach of a larger portion of the buying public.IHS expects Kindle Fire's rapid ascent to help fuel the expansion of the entire tablet market, now predicting that 64.7 million tablets will be shipped in 2011, higher than its previous forecast of 60 million issued in August.The total tablet shipment number this year will represent a 273- percent growth from 17.4 million units in 2010, said IHS, which has also increased its longer-term projection of global tablet shipment in 2015 to 287.2 million units.

BEIJING, Jan. 17 (Xinhuanet) -- India has reported the first case of "totally drug-resistant tuberculosis," a long-feared and virtually untreatable form of the killer lung disease.Similar highly resistant cases have been noted before. In 2003, two Italian women died and there were 15 cases reported from Iran in 2009. That same year, The Associated Press reported on a case of a Peruvian teenager who was infected at home but diagnosed while visiting Florida.Such kind of TB has mostly been limited to impoverished areas, and has not spread widely. But experts believe there could be many undocumented cases.No one expects the Indian TB strains to rapidly spread elsewhere.The airborne disease is mainly transmitted through close personal contact and isn't nearly as contagious as the flu. Indeed, most of the cases of this kind of TB were not from person-to-person infection but were mutations that occurred in poorly treated patients.The Indian hospital that saw the initial cases tested a dozen medicines and none of them worked. A TB expert at the U.S. Centers for Disease Control and Prevention said they do appear to be totally resistant to available drugs."It is concerning," said Dr. Kenneth Castro, director of the CDC's Division of Tuberculosis Elimination. "Anytime we see something like this, we better get on top of it before it becomes a more widespread problem."Ordinary TB is easily cured by taking antibiotics for six to nine months. However, if that treatment is interrupted or the dose is cut down, the stubborn bacteria battle back and mutate into a tougher strain that can no longer be killed by standard drugs. The disease becomes harder and more expensive to treat.Tuberculosis is an age-old scourge that lies dormant in an estimated one in three people. About 10 percent of those people eventually develop active TB, which kills roughly 2 million a year, according to WHO. Each victim infects an average of 10 to 15 others every year, typically through sneezing or coughing.If a TB case is found to be resistant to the two most powerful anti-TB drugs, the patient is classified as having multi-drug-resistant TB (MDR). An even worse classification of TB — one the WHO accepts — is extensively drug-resistant TB (XDR), a form of the disease that was first reported in 2006 and is virtually resistant to all drugs.About 20 percent of the world's multi-drug-resistant cases were found in India, which is home to a quarter of all types of tuberculosis cases worldwide.

SHANGHAI, Dec. 9 (Xinhua) -- China's homegrown C919 large passenger plane has finished its preliminary development review and entered the development phase, a senior executive of Commercial Aircraft Corporation of China Ltd. (COMAC) in Shanghai said Friday.An expert team of the C919 project has approved the overall preliminary development review (PDR) of the passenger jet, said Jin Zhuanglong, president of the Shanghai-based COMAC.It is expected that the manufacturing process for the components of the prototype will begin by the end of 2011.COMAC signed a deal to sell 20 C919 large passenger planes to China Aircraft Leasing Company Limited (CALC) on Thursday.Up to now, the users of C919 large passenger planes have reached 10 and total orders amount to 215 units.COMAC said earlier it would develop both 168-seat and 156-seat models of the jet, with more models to be developed in the future.It also said that test flights for the single-aisle C919 were scheduled for 2014, and delivery is slated for 2016.