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As questions arise over when a coronavirus vaccine should be granted FDA approval, the leaders of several major pharmaceutical companies announced they have signed a pledge not to rush the development of a vaccine.The companies, AstraZeneca, BioNTech, GlaxoSmithKline, Johnson, Merck, Moderna, Novavax, Pfizer and Sanofi, released a joint statement on Tuesday confirming the pledge.The pledge includes the following points:Always make the safety and well-being of vaccinated individuals our top priority.Continue to adhere to high scientific and ethical standards regarding the conduct of clinical trials and the rigor of manufacturing processes.Only submit for approval or emergency use authorization after demonstrating safety and efficacy through a Phase 3 clinical study that is designed and conducted to meet requirements of expert regulatory authorities such as FDA.Work to ensure a sufficient supply and range of vaccine options, including those suitable for global access.There has been pressure on both the FDA and manufactures to develop and approve a vaccine for the coronavirus. There have been more than 190,000 coronavirus-related deaths in the US since March, and the economic impact of the virus has cost millions of jobs.While most developed countries have not had the same public health pain as the US, the economic impact of the virus has been felt worldwide. The International Monetary Fund estimates a nearly 5% loss in global GDP in 2020.In Russia, the country claimed to begin distributing a coronavirus vaccine despite US-based vaccine candidates likely being months away from being able to demonstrate efficacy.The pressure domestically has also ratcheted up as President Donald Trump has suggested a vaccine could be ready by this fall’s presidential election."We're going to have a vaccine very soon... maybe even before a very special date, you know what date I'm talking about,” Trump said on Monday.In late August, the CDC told states to begin to prepare distributing a vaccine by Nov. 1. But Surgeon General Jerome Adams said that just because states will be ready to help distribute a vaccine on Nov. 1 does not mean a vaccine will be ready by then."We've always said that we're hopeful for a vaccine by the end of this year or the beginning of next year,” Adams told Good Morning America."We want to make sure states are available to distribute it," he added.The companies signing on the pledge said that the FDA has strict protocols for vaccine candidates. A typical vaccine trial takes one to three years, but the companies believe only a safe and effective vaccine will be granted approval.“FDA has established clear guidance for the development of COVID-19 vaccines and clear criteria for their potential authorization or approval in the US,” the companies wrote in the pledge. “FDA’s guidance and criteria are based on the scientific and medical principles necessary to clearly demonstrate the safety and efficacy of potential COVID-19 vaccines. More specifically, the agency requires that scientific evidence for regulatory approval must come from large, high quality clinical trials that are randomized and observer-blinded, with an expectation of appropriately designed studies with significant numbers of participants across diverse populations.” 3296

At a time when people across the country are calling to defund the police, or outright abolish them, convincing others to make a career in law enforcement could be a tough sell.For Cameron Mosher, however, the decision to put on the badge for a living is an easy one.“For me, it’s always been an urge to serve my community,” he said.Mosher is training to be a deputy sheriff at the Orange County Sheriff’s Regional Training Academy in Southern California.“I want to try to be that positive change in law enforcement to try to help and move forward with this career,” he said.Moving forward and maintaining order as the country deals with a pandemic and social unrest.“I have a brother in St. Louis, Missouri, not too far from Ferguson, and we’ve had some interesting debates over the last five or so years,” said Lt. Joses Walehwa, who is helping train a new group of recruits at the Orange County Sheriff’s Regional Training Academy.Walehwa says his team is preparing the next generation of law enforcement officer for much more than traffic stops and arrests.“As an African American, or really any minority group here in America, has a unique perspective when it comes to just their lived experience growing up,” he said. “I think for me, the biggest impact is bridging the gap. You know, bridging this issue of us versus them.”Walehwa says another huge impact when it comes to recruiting is the economy.“When the economy starts to dip, you see that people start to look for stable jobs,” he said. “Law enforcement and public sector and jobs like ours become a little bit more appealing because people see the stability of the job.”A job where despite a pension and a mean annual wage of more ,600 (Bureau of Labor Statistics), there’s still a major need for more sheriff’s deputies across the country.A recent report from the Police Executive Research Forum shows 36% of respondents said the number of applicants at their agency has “decreased significantly.”For recruits like Mosher, however, working in law enforcement means much more than money. It’s about building trust in his community while also addressing new challenges and raising the standards of law enforcement officers.“We see definitely a lot of people who are not necessarily supportive of law enforcement right now,” he said. “But in the end, that’s totally OK, because we’re here to support everyone. We’re going to protect everyone equally.” 2424

As New Haven, Connecticut, Fire Chief John Alston Jr. spoke to reporters about a spate of drug overdoses on Wednesday, he heard shouting coming from behind him."We're getting another call of a person," Alston said.He quickly helped coordinate the response, and then returned to the microphone.That scene came on the same day that as many as 71 people in the area of New Haven Green were believed to have overdosed on some form of K2, according to New Haven police spokesman Officer David Hartman.New Haven Green is a large park and recreation area in the city's downtown.The patients included people of various ages and demographics, Alston said."It's a nationwide problem. Let's address it that way," he said. "It's a nationwide problem that people are self-medicating for several different reasons, and every agency -- police, fire, medical hospitals -- all are strained at this time. This is a problem that's not going away."New Haven police said one person is in custody.Rick Fontana, director of Emergency Operations for New Haven, said the patients had symptoms of increased heart rates, decreased respiratory rates and a lot of vomiting. Some people were unconscious, others were semi-conscious.No one has died, but two individuals are considered to be in serious, life-threatening condition. Some individuals who were released from the hospital needed to be treated a second time for an additional apparent overdose, Fontana said.K2 is a synthetic cannabinoid related to marijuana that is frequently laced with other drugs, said Dr. Sandy Bogucki of the Yale School of Public Health.In two cases, Narcan was not effective in the field, but a high dose of Narcan at the hospital was effective in combating the overdose effects. Authorities confirm the substance was synthetic cannabis and that other drugs weren't involved in the substance.The response from emergency responders has been "tremendous," Fontana said.He said authorities have been treating and sometimes transporting six or seven people at one time and the actions of first responders have been "lifesaving.""We hope this is coming to an end, but it's too early to tell."The-CNN-Wire 2162

Attendance at San Diego Padres home games is on pace to finish more than 11 percent higher than the turnout for 2018. Through 65 home games, the team has drawn an average 30,200 fans per game. In 2018, the Padres drew an average 26,967 fans to games at Petco Park.The team made a splash in the offseason by signing superstar third baseman Manny Machado to a 0 million contract. Plus, excitement surrounding rookie Fernando Tatis Jr., now injured, has helped to draw fans. The Padres, still below .500, have also won 10 more games at this point in the season than they had at the same time last year. Olivia Millay, a server at Social Tap, which is next to Petco Park, says the increased attendance has helped business. "People are getting a lot more excited," she said. "I feel like last year there was almost more people cheering for the other team that would come here. Now you're seeing a lot more Padres jerseys. You've got Machado, Tatis, ya know?"But the uptick in attendance hasn't helped all business equally. There are still multiple shuttered storefronts near Petco Park, including the site of what used to be Tilted Kilt on 10th Avenue. Alina Ahmed, who owns Cafe de L'Opera, across from Petco Park, said high rents hurt. Plus, she pointed to issues with the area's homeless population that can keep customers away. "In the morning everyday we have to remove transients that are sleeping, along with many other issues," she said. Ahmed said the increased attendance has helped a bit, but can only do so much. 1531

As the saying goes, beauty is in the eye of the beholder. And when it comes to appreciating art, that may be more true than ever. It's so subjective and comes down to true appreciation. One woman understands that more than most.To Myrna Hayutin the photos on her gallery wall are more than pictures of the past. She points out some of the art on display.  "This is a limited edition signed by Carl Mydans," Hayutin said. "This is Babe Ruth the last time he put on his uniform."These are works of art."It is history," Hayutin said. "It's just knowledge."And for the last 35 years she's been selling fine art like these pieces, despite the fact that she's legally blind."I anticipate doing this for at least another 10 years," Hayutin said. "As long as my eyesight holds."Hayutin started losing her eyesight when she was eight due to retinitis pigmentosa. And over the years, it's gotten progressively worse."It's like an island," Hayutin said. "As the disease progresses the island gets smaller and smaller now I see through two straws. So you may be standing right here but I am not seeing you. Or if were talking and you move I'll lose you."Still it hasn't affected her love for art or her determination to purse it as a career."It never occurred to me to stop me from doing anything that I really wanted to do," Hayutin said.Hayutin runs a successful international fine art gallery, Gallery M, and recently became an art appraiser."I'm looking at the artwork but honestly thank goodness with my devices I can really zoom in and see them much, much better," Hayutin said.Hayutin said her dog, Gouda, helps her navigate the changes in her eyesight, but what helps most is not focusing on what could happen."I would never have opened the gallery if I was fearful of what would be instead of what was at that time," Hayutin said. "I try to live in today and use the eyesight that I have today."Hayutin said every day is what you make it."There are some days where I'm not as positive as I should be, but I try it," Hauytin said. "I try to get back on that positive I mean because I'm surrounded by all of this gorgeous art and that's very uplifting."  2212