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SAN DIEGO (KGTV) - Anyone touched by Alzheimer's knows how painful the disease is. "It's affected my family. It's affected most families. It's such a prevalent disease. As people get older, it becomes quite likely this will become an issue," said Paul Aisen, director of USC's Alzheimer's Therapeutic Research Clinic (ACTC).Aisen's team began their research in San Diego many years ago and teamed up with USC about four years ago. He's spent over 30 years trying to solve Alzheimer's mysteries and is leading the upcoming clinical trial.Aisen says the large-scale study is the culmination of decades of work from scientists worldwide."Our focus lately has been trying to alter the disease, prevent it, or significantly slow its progression. How should we do that? We think attacking amyloid early is the most promising approach," said Aisen. Researchers believe sticky amyloid deposits, which form on the brain later in life, start the Alzheimer's process. Aging, genetics, and lifestyle factors can all contribute to amyloid build-up.The worldwide clinical trial aims to target amyloid. A drug called BAN2401 will be delivered intravenously, designed to bind to the sticky amyloid. The binding neutralizes beta amyloid and helps "tag" it, so the immune system can recognize it and clear it from the brain. A previous phase 2 study showed that BAN2401 removes brain amyloid and possibly slows cognitive decline.They're seeking participants over 50 who are not yet showing symptoms of Alzheimer's but do have elevated amounts of amyloid on their brain. Researchers can determine that through a PET scan or spinal tap. "We think that the most promising approach of all is to take a vigorous attack on amyloid while the brain is still functioning normally. And we can see amyloid in people many years before they develop the symptoms of Alzheimer's."Investigators hope that by treating a patient with BAN2401 very early in the disease, before symptoms occur, it will significantly slow disease progression. "If we're successful, it will have a huge impact on human health," said Aisen. There will be 100 sites worldwide for the study, including major cities like San Diego and Los Angeles. Study participants will receive treatment for four years, given either the drug or a placebo. Results are expected in seven years, Aisen says. If you or a loved one wants to participate, learn more here.Screening will officially begin in May. 2438

SAN DIEGO (KGTV) – At a press conference on Wednesday afternoon, San Diego Police Chief David Nisleit and San Diego Mayor Kevin Faulconer announced new policies on de-escalation and an officer's duty to intervene.Mayor Faulconer said the changes come three weeks after he called for a series of public meetings for feedback on community and police relations.“These policies are meant to protect the officer as much as the subject and prevent escalation whenever possible before force is used,” he told reporters.The first of SDPD'S two new stand-alone policies requires officers, when safe and reasonable, to use techniques that can resolve situations either through lower levels of force or no force at all.The second new stand-alone policy requires officers to step in if another officer is using unreasonable force and mandates that they report the incident to a supervisor.“Let me be clear. It's not as though the SDPD was operating without de-escalation tactics before but now the department has separate, expanded stand-alone policies that don't just suggest de-escalation, they require it,” added Mayor Faulconer.“It's an absolute. It's a mandate that if an officer sees an officer using force that is unreasonable for the obstacle that they're trying to overcome, that the officer must intervene,” said Chief Nisleit.Samantha Jenkins with the Community Advisory Board on Police Practices and NAACP San Diego told reporters, “This new level of built-in accountability will hopefully usher in a new culture of policing in San Diego.”“We thank God for everyone that's been a part of this. Community, keep speaking. We hear your voice,” added Bishop Dr. William Benson with the Total Deliverance Worship Center.Chief Nisleit said these changes are a step in the right direction but the department will continue to look at best practices across the nation and how officers can continue to best serve this city. 1921

SAN DIEGO (KGTV) — As the elderly population is told to stay home to protect themselves from coronavirus, a group like ElderHelp is necessary. ElderHelp has been helping seniors with anything from giving rides to grocery shopping for decades. Now, they have adapted to COVID-19 restrictions, with a system where volunteers pick up groceries from the nonprofit's hub, then drive the food and supplies to the seniors’ homes to deliver without contact.ElderHelp has seen a 773% increase in requests for service since the pandemic began and now completes 522 deliveries on average every week.Carol Greene is one of the seniors who has food delivered to her San Diego home and said the communication with the staff brightens her days.“I look at ElderHelp as all the sunshine. You might be at home on your normal, boring day at times and whoop there’s the phone,” she said.They just received a 0,000 grant from the San Diego Foundation but say they are still always in need of both donations and volunteers, especially in light of the recent increase in demand.Nicole Darling has been volunteering with ElderHelp since 2003 and said the seniors appreciate the food, but always seem to enjoy the interaction as well, especially during a time of isolation.“It’s a small amount of effort to make a huge amount of good for people who are really vulnerable and alone,” said Darling. 1382

SAN DIEGO (KGTV) - Crime Stoppers released photos Wednesday to find a man and woman suspected of two armed robberies in Otay Mesa and Pacific Beach. The first robbery happened the afternoon of Sunday, July 28 at Tepito Club, a clothing store at 2364 Roll Drive. Police said the pair selected merchandise and approached the clerk, then the woman pulled a gun and demanded cash. The couple took the money and drove off in a blue Toyota Corolla. One day later, police said the two suspects gathered items at the Chevron gas station at 1575 Garnet Ave., eventually demanding cash from the clerk. The man and woman walked away from the area with the money, police said. The suspects are both white, according to Crime Stoppers. The woman is 5’6”, thin, and was wearing a black tank top and grey leggings. The man has a medium build, and is about 30 years old with tattoos. Anyone with information is asked to call Crime Stoppers at 888-580-8477. Information leading to an arrest can result in a ,000 reward. 1012

SAN DIEGO (KGTV) — Cinema and sunsets return to San Diego parks this summer as the county's Summer Movies in the Park program returns.The free outdoor movies every Friday and Saturday come to parks across San Diego County between May and October.Families can enjoy concessions and food trucks at some movie screenings, but should check with the event before heading over. Otherwise, it's the perfect chance to pack a picnic and enjoy a a free movie outdoors.RELATED: Special movies for kids coming to Bonsall's AMC this summerMoving seats, weather effects, scents come to Mira Mesa movie theaterOrganizers recommend showing up early for a good seat as prime viewing for screenings can fill up fast.For a full schedule of movies and where they'll be playing, check out the program's schedule. 802