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WASHINGTON, Dec. 12 (Xinhua) -- British scientists have discovered a new way to target cancer through manipulating a master switch responsible for cancer cell growth. The findings, published Monday in the U.S. journal Cancer Cell, reveal how cancer cells grow faster by producing their own blood vessels.Cancer cells gain the nutrients they need by producing proteins that make blood vessels grow, helping deliver oxygen and sugars to the tumor. These proteins are vascular growth factors like VEGF -- the target for the anti-cancer drug Avastin. Making these proteins requires the slotting together of different parts of genes, a process called splicing.Scientists at the University of West England and the University of Bristol discovered that mutations in one specific cancer gene can control how splicing is balanced, allowing a master switch in the cell to be turned on. This master switch of splicing makes cancer cells grow faster, and blood vessels to grow more quickly, as they alter how VEGFs are put together.In experimental models, the researchers found that by using new drugs that block this master switch they prevented blood vessel growth and stopped the growth of cancers."The research clearly demonstrates that it may be possible to block tumor growth by targeting and manipulating alternative splicing in patients, adding to the increasingly wide armory of potential anti-cancer therapies," the authors said.

UNITED NATIONS, Oct. 28 (Xinhua) -- China's progress in meeting a development goal on children's health can serve as an inspiration to other countries working towards the same objective, Dr. Renee Van de Weerdt, chief of maternal, newborn and child health at the UN Children's Fund (UNICEF) told Xinhua in an interview Friday.Van de Weerdt said that "the example of China is very encouraging because it means it can be done, even in a very big country with a very big population."China is on track to meet the fourth Millennium Development Goal (MDG), one of the eight development targets that the international community has pledged to meet by 2015. MDG 4 requires that each country reduce its rate of mortality for children under age five to two-thirds of what it was in 1990.According to Van de Weerdt, most deaths of children under five take place in the first month of life. After the first month, the most prevalent causes of death are pneumonia and diarrhea.ACHIEVING THE GOAL WORLDWIDEThe international community has been doing "relatively well" in working towards achieving MDG 4, Van de Weerdt said.The UN Interagency Group for Child Mortality Estimation (IGME) stated in their 2011 Report on Levels and Trends in Child Mortality that the number of under-five deaths worldwide has dropped from more than 12 million in 1990 to 7.6 million in 2010."We really continue to see progress," Van de Weerdt said. "The number of children that die every year continues to drop so we are really pleased to see that progress. Unfortunately, the progress isn't sufficient to really be able to say that if we continue at this pace we would achieve MDG 4 by 2015."Some regions, according to Van de Weerdt, like Latin America and parts of Asia are making more headway towards the goal than others that are currently lagging behind.

SUVA, Dec. 18 (Xinhua) -- There are 60 typhoid cases in Nanoko, with 29 already hospitalized, according to Fiji's Health Ministry.Senior Health Inspector Paula Laqere said Sunday that the increas means that people are not practicing proper hygiene standards. Laqere said most of the communities in Fiji have a really low level of good hygiene practices.The other problem is that some communities in Fiji have very poor sources of clean and safe water and this is what Fijian guests need to be cautious of."Typhoid is basically spread through contaminated water and our hygiene practices. It's an indicator that the sanitation level of any community is really low."A 30 day public health emergency is in place for the village, effective from Dec. 12 to Jan. 12.Recently, Fiji recorded rates of high typhoid fever in the world, said WHO South Pacific Communicable Disease Surveillance and Response Team leader doctor Jacob Kool.Kool said typhoid fever was difficult to diagnose and could be fatal in 10-20 percent of untreated patients.Recent studies showed that infants are commonly affected and are extremely vulnerable to the disease. Outbreaks occur regularly in areas with poor hygiene and sanitation including urban slums, he said.Kool said the only reliable symptom was prolonged fever and blood and stool culture are still the best available diagnostic tests but have a high rate of false negative results. He said therefore suspected typhoid cases should be treated regardless of the result of lab tests and ciprofloxacin was the recommended therapy for all age groups.Last year AusAID, WHO and UNICEF launched a typhoid fever vaccination campaign in Fiji.

BEIJING, Nov. 28 (Xinhuanet) -- A majority of the emergency hospitalizations for bad events related to medication use in old U.S. adults stem from four common medications, according to a new study in the New England Journal of Medicine Monday.The study was conducted by researchers from the Centers for Disease Control and Prevention of U.S.There are nearly 100,000 emergency hospitalizations for adverse drug events in older Americans, says researcher Daniel S. Budnitz, MD, MPH, director of the CDC's Medication Safety Program.And the four types of medication -- two for diabetes and two blood-thinning agents -- account for two-thirds of those drug-related emergency hospitalizations. They most often cited: warfarin (Coumadin, Jantoven); insulin; antiplatelet drugs such as aspirin and clopidogrel (Plavix); oral hypoglycemic agents."Both blood thinners and diabetes medicines are critical drugs that can be lifesaving," Budnitz says.However, he says that ''these are medications that you do need to pay attention to," being sure the dose and timing are correct, among other measures.

BEIJING, Dec. 11 (Xinhua) -- China is faced with severe challenges in collecting enough blood plasma to produce medicines, Health Minister Chen Zhu said Sunday.Chen called on the public to join blood donation after donating blood plasma at the Beijing Red Cross Blood Center on Sunday, the fifth time since he took office in 2007.Blood plasma is needed to make blood products like prothrombin complex which is vital for hemophiliacs.The total volume of blood plasma collected last year was 4,180 tonnes, while the volume needed to produce enough medicines was 8,000 tonnes, said a statement from the ministry. The situation became even worse this year.Donations of blood plasma in China fell dramatically in recent years, as a result of safety concerns from donors and the government's efforts to regulate blood collection after contamination triggered HIV infection scandals.In an overhaul of plasma collection services in 2004, the ministry closed 262 donation centers, leaving only 138 in operation, resulting in the plasma donations falling at least one-third from 5,000 tonnes in 2003.Blood plasma are currently collected at 144 designed stations across the mainland. The stations, as requested by law, are all owned by major manufacturers of blood products.Chen promised to encourage qualified drug makers to set up more collection stations in the next five years.He also assured the public the safety of blood donation at authorized stations.