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SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) - Concerns and questions remain about why the County of San Diego won't release the locations of restaurants or grocery stores where employees have tested positive for COVID-19. The big question is, does the public have a right to know about specific locations where workers have tested positive? 10News continued on Tuesday to try to get answers since County officials confirmed on Sunday that multiple local food handlers have tested positive. On Monday, Sprouts confirmed that two employees from its Carlsbad store tested positive.It comes after the County confirmed that an Escondido Albertson's employee tested positive after 10News independently confirmed it Saturday.The County also reported that four local restaurant workers tested positive, but wouldn't say where.During Monday's press conference, 10News asked the County, “Should the public have a right to know which restaurants may have workers who have tested positive?” Dr. Nick Yphantides eventually said in part, “As far as the naming of the restaurants and so forth, it is only appropriate and relevant if there is actionable data upon which we are looking for members of the public or individuals to follow up on.”In the same press conference, Dr. Eric McDonald clarified that in certain disease cases, the County does provide names and locations, adding, “It's because it's specifically for the public to do something. We did that in Hepatitis A. We specifically named a restaurant so that individuals who patronized that restaurant could get shots to prevent illness.”He stressed that with coronavirus, it's different, saying, “In the case of COVID-19, because of the widespread community transmission, the advice to the public in a specific named restaurant would be no different than what we're giving already to the general public which is to stay at home [and] to social distance.”The County sent 10News the following statement on Tuesday afternoon."The County does not share the names of specific restaurants or grocers who have employees who test positive, but does not prohibit or discourage the respective entities from reporting the information if they feel it is in the interest of public health. We don’t report the names because, unlike in cases of TB, there is no additional action the public needs to take. Restaurants have very clear guidelines and have been diligent about following those guidelines as well as CDC protocols. Consumers need to take the same precautions to protect themselves at every restaurant they choose to pick up from by social distancing, regularly washing their hands and self-isolating if they develop any symptoms. Each restaurant worker case reported to County DEH is investigated by public health and DEH. In every case, an evaluation is made to determine if the worker worked while symptomatic and if their duties involved food handling that might put the public who ate at the restaurant (or purchased food at a grocery store) at any greater risk than general community exposure. In all instances thus far, no greater risk has been identified. It is important to note the CDC has said that currently there is no evidence to support transmission of COVID-19 associated with food. [cdc.gov]If the public is concerned about what their grocer or take out restaurant is doing to make their location safe, they should ask... most will be happy to tell you. And so far, in all identified instances, these entities have done everything RIGHT in terms of actions for public health.... notice, cleaning, job analysis. There is no need for the public to do anything different based on this information about the grocers who have reported cases so far...indeed, one could argue that would be one of the safest places to shop, given their transparency on this case." 3796

SAN DIEGO (KGTV) -- As the world outside continues to change in drastic and dramatic ways, it’s easy to feel stuck in stress and despair.ABC/10News anchor Kimberly Hunt speaks with a Holocaust survivor who has devoted her life to inspiring others to change the imprisoning thoughts and destructive behaviors that may be holding us back.Dr. Edith Eger’s empowering conversation helps us see our darkest moments as our greatest teachers. She says true freedom only comes when we confront the past, as well as this pandemic, with strategies and tools for finding the gift in every day. It’s an investment in the future, the conviction to focus not on what we’ve lost, but on what’s still here.She’s also written lessons for breaking out of personal prisons in order to live a full life in her new book: The Gift. Click here for more information. 851

SAN DIEGO (KGTV) — Convoy Street already seems like its own neighborhood to many, always bustling with locals at its numerous Asian restaurants and shops.Thursday, community business leaders continued their efforts to put Convoy Street firmly on San Diego's map with a live mural painting art show.The mural, created by local artist Espa?a Garcia Feucht, covers the side of Cross Street Chicken and Beer and was painted live in tandem with Taiko drummers playing and other artists showcasing their work outside the restaurant. District 6 Councilmember Chris Cate was also in attendance to herald in the new neighborhood feature.RELATED: 10 must-eat restaurants on San Diego's Convoy StreetTommy Nguyen, owner of Cross Street, said the mural is just the first step in local efforts to get Convoy Street its own neighborhood sign, like ones currently over the Gaslamp Quarter and University Heights."Knowing that it'll take some time for the physical arch to go up, we decided to take matters into our own hands and put up a 'Welcome to Convoy' arch ourselves on our mural wall," Nguyen said. "I truly believe that Convoy is big enough to have it's own neighborhood arch."The mural features a rooster holding a beer (a tip of the hat to the region's craft beer scene and the restaurant the mural sits on) with the phrase "made in San Diego" underneath. Next to the rooster is the painted "Welcome to Convoy" archway.RELATED: Convoy Street's Churreria churning out made-to-order churrosThe hope for Nguyen, between the mural and future art events hosted by his restaurant, is that Convoy Street will become more than a foodie destination."Just kind of seeing the movement all around town but not in Convoy," Nguyen started. "We want to introduce Convoy to the younger street art scene. I want people to recognize this mural eventually and say, 'oh yeah, that’s in Kearny Mesa.'"Our hope is to raise awareness enough for [people] who are not familiar with Kearny Mesa/Convoy to come to this area and explore for themselves." 2028

SAN DIEGO (KGTV) - Border Patrol agents and San Diego Police are at the scene of a possible suspicious device in Otay Mesa, officers confirmed Wednesday.Police said they got a call from Border Patrol about 3 p.m. telling them about a possible threat in a vehicle in a tow yard on the 9000 block of Airway Road.The vehicle had been seized during a drug smuggling investigation, police said.San Diego officers sent canine units to the scene and helped establish a perimeter.California Highway Patrol closed one lane on eastbound I-905 exiting onto SR-125. Check traffic here.There was no immediate report of evacuations or information about the type of device.10News is monitoring breaking developments. 709

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