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SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524
SAN DIEGO (KGTV) — San Diego Fire crews responded to a first-alarm brush fire in an east San Diego neighborhood Saturday.The fire ignited near the 5700 block of Bates Street around 1 p.m. in the Redwood Village neighborhood of east San Diego. Within 15 minutes, crews had stamped out the half-acre fire.No evacuations were ordered, according to SDFD.The cause of the fire wasn't immediately known. 405
SAN DIEGO (KGTV) -- San Diego Police are asking for the public’s help locating a man suspected of threatening a Target employee with a razor during a robbery.Police say the incident happened around 10 a.m. on March 25 at the Target on the 1200 block of Camino Del Rio North.According to police, a loss prevention officer noticed a man inside the store he recognized from previous encounters.Police say the man grabbed three memory cards and attempted to remove them from their cases.After removing one of the memory cards and placing it in his pocket, the man was confronted by the officer who followed him to the exit.The suspect then threatened the officer with a folding razor knife he removed from his waistband.The suspect is described as a six-foot tall 28-year-old white male wearing a tan colored long-sleeve dress shirt, blue jeans and black tennis shoes.Anyone with information is asked to call San Diego Police at 619-531-2299. 951
SAN DIEGO (KGTV) -- San Diego Police are investigating after a 12-year-old skateboarder was hit by a car in Mira Mesa Monday night. According to police, the crash happened on Reagan Road near Calico Street before 6:30 p.m. Police say the 12-year-old was taken to the hospital with major head injuries. Traffic is closed in the area as police continue to investigate. At this time, the circumstances surrounding the crash are unclear. 442
SAN DIEGO (KGTV) — San Diego County has served Pacers Showgirls International with a cease and desist order in violation of health orders days after San Diego Padres outfielder Tommy Pham was stabbed outside the strip club.The county's letter says the Midway District strip club was allowing "live entertainment," like exotic dancing, "in violation of the Order of the State Health Officer and County Order of the Health Officer and Emergency Regulations."Under the county's current tier for California's pandemic guidance, San Diego County restaurants are allowed to operate outdoor in-person dining and indoor in-person dining at 25% capacity, but live entertainment is not allowed.The county's letter says if the strip club doesn't suspend its entertainment, it can receive a misdemeanor citation and ,000 fine for each violation. The facility could be ordered to close as well.The order says the violations were reported after Pham was stabbed in the parking lot outside the strip club on Sunday night.San Diego Police said Pham was involved in an altercation. He is expected to make a full recovery.Pham said the experience was, "very traumatic and eye-opening experience for me, I’m on the road to recovery and I know I’ll be back to my offseason training routine in no time."Anyone with information on the stabbing is asked to call SDPD at 619-692-4800. 1370