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CLEVELAND — Scientists at the Cleveland Clinic Lerner Research Institute have successfully reversed Alzheimer's disease in mice.According to a news release, the researchers reversed the formation of harmful plaque in the mice's brains by gradually reducing an enzyme called BACE1, improving their mental function.“To our knowledge, this is the first observation of such a dramatic reversal of amyloid deposition in any study of Alzheimer’s disease mouse models,” says Riqiang Yan, one of the scientists on the team. The study raises hopes that drugs aimed at this same enzyme will soon be able to treat Alzheimer's disease in humans. You can read the full study in the Journal of Experimental Medicine here. 735

CORPUS CHRISTI, Texas — Firefighters are battling a major fire in Corpus Christi following a pipeline explosion along the city's refinery row.The blast happened just after 8:05 a.m. near Lantana and I-37, possibly at EPIC Products near Lantana and Navigation.Firefighters said the fire ignited a barge, which became fully engulfed. The fire then spread from the pipeline to the grain elevator.KRIS reports that multiple people during the explosion ended up in the water.CHRISTUS Spohn Shoreline representatives said they are treating four people from the explosion. The extent of their injuries is unknown at this time. Two victims are being flown to Brooke Army Medical Center burn units in San Antonio.Corpus Christi Mayor Joe McComb said there is a search and rescue operation for four people who are still missing.KRIS has learned that EPIC Products had a brand new pipeline built for loading. It was reportedly going in at the facility when there was a pipeline rupture at the barge loading dock.According to Lieutenant Marina Lyons with the US Coast Guard, a dredge struck a submerged pipeline causing a fire in the Corpus Christi ship channel. The owner of the barge said they had multiple employees working at the site at the time of the explosion.The Corpus Christi Police Department has closed off Lantana Street to traffic as crews work to contain the inferno. 1379

COLLEGE STATION, Texas -- Two sororities at Texas A&M University are forced to quarantine after having been exposed to COVID-19.The university announced the activities and members of Kappa Kappa Gamma and Delta Delta Delta are experiencing exposure to the virus.Texas A&M has initiated chapter-wide quarantine and contact tracing for those who live in the sorority houses or elsewhere and were in contact.The chapters have been responsive and are responsibly following required steps to continue operations, according to the university.Students, faculty, or staff who receive a positive diagnosis or believe they have been exposed to a positive case must complete a form through the university's reporting portal.Gatherings have also been restricted to 10 or fewer people.Texas A&M kicked off the fall semester both online and in-person on August 19.This story was first reported by Sydney Isenberg at KXXV in Waco, Texas. 942

Consumers, especially men, should not purchase or use two e-cigarette liquids that contain popular erectile dysfunction drugs, the Food and Drug Administration warned Tuesday.The two HelloCig e-liquids contain tadalafil and sildenafil, the main ingredients in two of the most popular male enhancement drugs on the market, the FDA said. "These FDA-approved prescription drugs are not approved for inclusion in e-liquid products sold over the counter and are therefore being sold illegally."By not properly labeling the e-liquids, the agency said, the company was not providing adequate warnings for the protection of users, specifically anyone with erectile dysfunction, high blood pressure, diabetes, high cholesterol or heart disease who take nitrates to manage their condition."These undeclared ingredients may interact with nitrates found in some prescription drugs such as nitroglycerin and may lower blood pressure to dangerous levels," the FDA said in its warning.A lab analysis found both sildenafil and tadalafil in E-Cialis HelloCig E-Liquid and sildenafil in E-Rimonabant HelloCig E-Liquid, both sold by Shanghai-based HelloCig Electronic Technology Co. Ltd.The company has not responded to a request for comment.Although no adverse events have been reported to the agency, all consumers should stop using the products immediately, the FDA said, and anyone who experiences side effects should report them to the FDA's MedWatch Adverse Event Reporting program.The FDA says it sent a warning letter to HelloCig in October, citing a number of concerns about illegal marketing claims. HelloCig was misbranding and selling its products in the United States as an "FDA approved product with FDA," in violation of federal rules."FDA recently warned HelloCig of these issues and contacted the company several times to recommend they recall these products due to the risks to consumers. However, HelloCig has not responded to the agency's recommendation," the agency said in its warning.Bottles of E-Cialis HelloCig E-Liquid were sold with an image of a Cialis bottle and tablets, while advertisements on Twitter and Tumbir showed "a partially undressed couple embracing," the FDA says. The caption states, "WOOOOW, Have you tried our E-Cialis? It is amazing LOL."Though E-Rimonabant HelloCig E-Liquid contains the same active ingredient as Viagra, the FDA said HelloCig was marketing it with an image of an Acomplia container and tablets."Acomplia is the tradename of the anti-obesity drug product in Europe," the FDA warned. "Using the tradename of the drug product Acomplia and including an image of the Acomplia container and tablets next to the product on your website suggests that the product is intended to treat obesity."HelloCig did not respond to the initial warning, the FDA said.The manufacturers of Cialis has not responded to requests for comment. The maker of Viagra had no comment. 2932

CINCINNATI — Ringed by neurosurgeons in sky-blue scrubs, masks and magnifying loupes, Makenzi Alley lay on a Jewish Hospital operating table and smiled. Her brain glistened pink and purple under the electrode they used to cautiously probe it; sharper implements awaiting their turn in the procedure shone nearby.At Dr. Vincent DiNapoli's signal, Alley began to speak. The team went to work.Wide-awake brain surgery might sound like a nightmare to many, but it was the only way doctors at Jewish Hospital's Brain Tumor Center could remove the tumor that had stolen Alley's sense of taste without damaging the vital tissue nearby."Of all the places to pick, it's kind of right in the spot you wouldn't want it to be," DiNapoli said, gesturing to a scan of Alley's brain in which the tumor stood out as a circular mass of solid white.Even a slight mistake could permanently rob her of her ability to produce spoken or written language — and, if she were fully anesthetized, her team might not know until she woke up."I knew he needed me to talk to do his best job, so I talked the whole time," Alley said months later, laughing. "There was never a time where I was like, ‘We need to stop,' and I started freaking out. It was very smooth. Very simple."DiNapoli's team used the electrode, her scans and her ongoing conversation as mapping tools. When she stopped talking, they knew they had touched the Broca area — the region of the brain that controls speech production — and needed to proceed carefully.The tumor they removed from Alley's brain was the size of a golf ball, she said. With it went the stutter she had developed as it pressed on her speech center; in its absence, her sense of taste returned.She was also able to return to the pastimes she loves, including playing guitar, studying and running competitively."That was actually an emotional sight to me," her mother, Traci Alley, said Thursday. She cradled her phone in her hand, displaying a picture of Alley smiling midway through a race. "She did so well. I wasn't sure I'd see her running again." 2095