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SAN DIEGO, Calif. – What’s usually a marathon for biotech companies is now a full-blown sprint to stop the spread of coronavirus.Kate Broderick, the Senior Vice President of R&D at Inovio Pharmaceuticals in San Diego, remembers the moment she first learned about the mysterious outbreak unfolding thousands of miles away. “Yes, absolutely, distinctly, probably one of those moments you’ll remember forever. I was in my kitchen at home the 31st of December,” said Broderick.She never imagined that two months later it would be the crisis it is today. “Every week I keep thinking it’s going to get better, it’s going to start to tone down a little bit, but in fact, rather than getting better it’s getting worse every week,” said Broderick.Inovio has made headlines before, creating vaccines for Zika, Ebola, and now the coronavirus. After Chinese researchers shared the genetic sequence of COVID-19, Inovio designed a vaccine in just three hours Using its proprietary DNA medicines platform technology. The vaccine was designed to precisely match the DNA sequence of the virus“In an outbreak setting we really don’t have two to three years to wait for a vaccine, so that’s where we come in at Inovio pharmaceuticals, we use DNA medicine technology,” said Broderick.While traditional vaccines use the virus itself, this method puts DNA inside E.coli, which naturally replicates the medicine over and over. The paste is then purified, leaving behind only the DNA medicine, which Inovio hopes to test in humans next month.“Infectious diseases are global and they don’t care about boundaries and borders, everyone is affected from childhood all the way through seniors,” said Phyllis Arthur, who’s been in the infectious disease industry for 20 years.Arthur is Vice President of Infectious Diseases and Diagnostic Policy at BIO, an association made up of about 1,000 companies.“One of the things we’re seeing, from outbreak to outbreak, unfortunately, is we’re getting faster at using platform technologies to build something that can be tried in humans sooner than we were the last time,” said Arthur.She’s following dozens of companies working on vaccines, treatments, and diagnostic tools. If their vaccines work, companies like Inovio will have to figure out how to manufacture them fast.“You may have the best vaccine in the world, but if you can only produce 1,000 doses of it, that’s not really going to help 1.4 billion people in China,” said Broderick. Continued funding will also be critical. Broderick says while their Zika vaccine looked promising in humans, it never ultimately got FDA approval for broad public use.“The problem there was, although great for global health, was that of course cases of the virus really steadily declined, the problem for us there was so did the funding,” said Broderick.She says that way of thinking is shortsighted but does see change on the horizon. “It’s a huge amount of responsibility on everyone’s shoulders, and I think we feel genuinely compelled to do everything in our power, hence why no one complains about two hours of sleep, because this is a point in our careers we can truly, literally, make a difference in saving lives, right now,” said Broderick.After the company begins human trials in the U.S., they’ll continue testing in China and South Korea. They hope to deliver one million doses by the end of the year.If they make it that far, it too would be a day Broderick will never forget. 3462

TAMPA, Fla. — While spring breakers head to beach communities, some Florida cities are enacting extra measures amid coronavirus concerns. In some areas of Fort Lauderdale, public beaches are closing daily at 4:30 p.m. and bars and restaurants must close before 10 p.m. Miami Beach reportedly enacted similar measures with an 11 p.m. curfew for bars and restaurants, as well as 4:30 p.m. beach closures, including on South Beach. Other states are closing bars and limiting restaurants to take-out only. Florida Governor Ron Desantis praised city leaders for the move and said he'd like to see other beach communities implement the same measures. "I think it’s important that these social distancing measures are implemented so that we are able to prevent infections from running completely out of hand," he said during a news conference Sunday. The concerns surrounding the virus didn't keep people away from Clearwater Beach over the weekend and on Monday, though. "I have auto immune diseases and I am a senior. But I really think as long as I’m very safe and I wash my hands constantly, I will be safe and my family will be safe," said Tricia Wood. Clearwater leaders met Monday to discuss the idea of adding curfews to the beach or closing the sand, but they did not come to a final decision. City leaders plan to discuss with county and state leaders and could make a final decision at Thursday's upcoming city council meeting. Meanwhile, the governor's office reported Visit Florida is re-evaluating tourism promotion messages and developing long term strategies to keep Florida in mind for potential future travelers. 1636

SANTA BARBARA, Calif. (KGTV) -- California State Parks officials worked quickly to protect centuries-old pictographs created inside sandstone caves from being destroyed in the fast-moving Cave Fire.The Chumash art, created by the Chumash Native Americans between 500 to nearly 1000 years ago, was covered by heat resistant tarps, a California State Parks ranger told KSBY.Chumash Painted Cave State Historic Park is one of the few remaining spaces that allow the public open access for viewing the rock art. Efforts to preserve the fragile paintings include prohibiting visitors from using flash photography.The Cave Fire was first reported Monday afternoon and exploded to over 4,000 acres in less than 24 hours, resulting in several evacuations, road closures, and an Air Quality Warning.These historic Chumash caves and their art have outlasted numerous fires, including the deadly Painting Cave Fire in 1990, which scorched over 4,000 acres. 957

Senate Majority Leader Mitch McConnell on Monday blocked efforts by his Democratic counterpart to pass via unanimous consent a resolution to make public special counsel Robert Mueller's report, the second time Senate Minority Leader Chuck Schumer has tried to do so.McConnell objected this time saying he wants to give Attorney General William Barr and Mueller time to complete their investigations and because Barr has committed to make as much of the report public, but he shouldn't be rushed."It's not unreasonable to give the special counsel and the Justice Department just a little time to complete their review in a professional and responsible manner," McConnell said on the Senate floor. "Remember, as I said earlier, we're likely dealing here with potential other prosecutions, classified information, damaging people's reputation. There's no evidence that the attorney general is not going to produce as much information as possible for all of us, and that's why I objected. I think it's a reasonable thing to do."Schumer criticized McConnell's objections, saying Republicans support the language in his resolution."This language was good enough for every Republican in the Senate as well as every Democrat," Schumer said following McConnell remarks. "The President himself says it should be released. It's hard to understand why the majority leader should stand alone with objections no one else found to be reasonable or sustainable and oppose this resolution. The report should be made public and the Senate should resolve that it should be."This same resolution 1588

Six people are dead after two floatplanes carrying cruise ship passengers collided in flight near Ketchikan, Alaska, on Monday, the US Coast Guard said.The Alaska State Troopers identified the deceased passengers as Simon Bodie, 56, of Tempe, New South Wales, Australia; Cassandra Webb, 62, of St. Louis, Missouri; Ryan Wilk, 39, of Utah; Louis Botha, 46, of San Diego, California; and Elsa Wilk, 37, of Richmond, British Columbia, Canada. Randy Sullivan, a 46-year-old pilot from Ketchikan also died.The Coast Guard, which is leading the investigation, said 10 people were rescued following the collision between a Beaver floatplane and an Otter floatplane.The Coast Guard had initially announced the death of four people on Monday, as authorities searched for two others who were missing.The bodies of the missing individuals were located Tuesday night, raising the death toll to six, the Coast Guard said.Floatplanes are aircrafts with pontoons or floats that allow them to land on water.The passengers on both planes were guests on a Princess Cruises ship -- the Royal Princess -- which is on a seven-day trip. There were 14 Americans, one Canadian and one Australian on board the two planes, according to the Coast Guard.The Royal Princess' voyage originated in Vancouver, British Columbia, over the weekend and is scheduled to end Saturday in Anchorage, Alaska, the company said. Part of the voyage, the company's website said, included "scenic glacier viewing" with stops at Juneau, Ketchikan and Skagway.The passengers on each planeThe two planes collided around 1 p.m. (5 p.m. ET). The Otter plane, operated by Taquan Air, a regional airline based in Ketchikan, was flying a shore excursion with 10 passengers and a pilot aboard. One of those passengers died, Princess Cruises said.Ten people from the aircraft were transported to the hospital. As of Tuesday night, three had been discharged. A 67-year-old man remains in serious condition, but is improving, a hospital spokeswoman said.The second plane was carrying four passengers and a pilot on an independent tour, the cruise line said. It was operated by Mountain Air Service, NTSB board member Jennifer Homendy said. Everyone aboard that plane was killed, according to the Coast Guard.The search for the two missing people The Coast Guard, Ketchikan Volunteer Rescue Squad, partner agencies and good Samaritans searched the shoreline and forested areas near the crash site for 27 hours, according to the Coast Guard.The "exhaustive search and rescue efforts" covered 93 square nautical miles, the Coast Guard said."We have been in regular contact with the family members throughout our search efforts," said Capt. Stephen White, Sector Juneau commander. "This is not the outcome we hoped for and extend our deepest sympathies during this very difficult time."Taquan Air released a statement saying it was "in the midst of an active crisis response, and our focus is on assisting these passengers, the pilot, our staff, their families and loved ones, and first responders.""Taquan Air has suspended all scheduled flights and is cooperating fully with the National Transportation Safety Board (NTSB), the Federal Aviation Administration (FAA) and other authorities to examine every aspect of this event," the company's statement said.No flight data recorders on either aircraftA 14-member NTSB team of investigators will try to determine what caused the crash, Homendy said during a news conference Tuesday.Eleven of them were on the scene Tuesday night with the other three on the way.Investigators will want to talk with surviving passengers, the pilot of the Taquan airplane, other employees of the air operators as well as other pilots and witnesses that were in the area at the time, Homendy said.They will also be requesting information from parties involved and looking at pilot log books, the training and qualifications of the pilots, any possible medical issues, whether flight plans were filed with the companies or FAA, maintenance records for the aircrafts as well as each company's operating procedures and whether those procedures were followed, she said.There were no cockpit voice recorders or flight data recorders on either of the two planes, Homendy also said during the news conference. Neither plane was required by regulation to have such recorders, she said.The two planes collided between 3,200 and 3,300 feet on the west side of George Inlet, according to Homendy.The wreckage is expected to be recovered Wednesday, Homendy said, and an NTSB structural expert will try to figure out how the two planes came together. 4617