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WASHINGTON, Oct. 9 (Xinhua) -- U.S. researchers have found a way to block, in an animal model, the damaging inflammation that contributes to many disease conditions. In their report receiving early online publication Sunday in Nature Biotechnology, researchers describe using small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage."The white blood cells known as monocytes play a critical role in the early stages of the immune response," says Matthias Nahrendorf, of the Massachusetts General Hospital (MGH) Center for Systems Biology, the paper's senior author. "We now know there are two subsets of monocytes -- an inflammatory subset that defends against pathogens and a reparative subset that supports healing. But if the inflammatory response is excessive, it can block the healing process and exacerbate conditions such as heart disease and cancer."Cells damaged by injury or disease release a cocktail of chemicals called cytokines that attract immune cells to the site of the damage. Inflammatory monocytes are guided to sites of tissue injury by a receptor protein called CCR2, and the MGH-led team devised a strategy targeting that molecule to block the inflammatory process but not the action of the reparative monocytes.Small interfering RNA (siRNA) technology prevents production of specific proteins by binding to associated messenger RNA molecules and preventing their translation. However, the technique requires extreme precision in developing the right siRNA molecule and delivering it to the correct cellular location.To make sure that their siRNA preparation targeted the right monocytes, researchers first confirmed that its use reduced levels of CCR2 in monocytes and increased levels of the fragments produced when siRNA binds to its target. They then showed that monocytes from mice treated with the siRNA preparation were unable to migrate towards CCR2's usual molecular target. Experiments in animal models of several important diseases showed that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets."These inflammatory monocytes are involved in almost every major disease," Nahrendorf explains. "Anti-inflammatory drugs currently on the market hit every inflammatory cell in the body, which can produce unwanted side effects. This new siRNA treatment doesn't affect inflammatory cells that don't rely on the CCR2 receptor. That makes a big difference."
BEIJING, Jan. 27 (Xinhua) -- China is committed to helping African nations to improve their abilities for self-development, Chinese Vice Commerce Minister Gao Hucheng said on Friday.Gao, also International Trade Representative of the Ministry of Commerce, made the remarks in an article published by Xinhua ahead of top Chinese political advisor Jia Qinglin's visit to Africa. Jia, chairman of th

SAN FRANCISCO, Oct. 17 (Xinhua) -- Apple on Monday announced that it has sold more than four million of its new iPhone 4S, three days after the launch last Friday."IPhone 4S is off to a great start with more than four million sold in its first weekend--the most ever for a phone and more than double the iPhone 4 launch during its first three days," said Philip Schiller, Apple's senior vice president of worldwide product marketing.In addition, more than 25 million customers are already using iOS 5, the latest version of the mobile operating system powering Apple's mobile devices, since it was released last Wednesday; and more than 20 million customers have signed up for iCloud, the cloud service designed to store and sync data for download to multiple devices, said the company in the statement.The iPhone 4S, which looks the same as the iPhone 4, has major hardware upgrade inside, including a faster chip, a higher- resolution camera and Siri intelligent voice control.Last Friday, AT&T and Sprint, two iPhone wireless carriers in the United States, said they have seen record daily sales with the launch of the iPhone 4S.The lasted Apple smartphone is currently on sale in the U.S., Canada, France, Germany, Japan and Britain, and will be available in 22 more countries on Oct. 28. Apple said the phone will be on sale in more than 70 countries and regions by the end of this year.
ADDIS ABABA, Dec. 2 (Xinhua) -- Xie Xiaoyan, the newly appointed Chinese ambassador to Ethiopia and the African Union (AU) on Friday presented his letter of credence to Jean Ping, chairperson of the AU Commission (AUC) at his office in Addis Ababa, Ethiopia.After presenting the credential letter to Ping at the AU headquarters, Ambassador Xie held talks with the AUC chief on the relations and cooperation between China and the union of 54 member countries.The Chinese government has constructed a state-of-the-art office complex and conference hall for the AU with an outlay of around 125 million U.S. dollars, a project that demonstrates the friendship between China and Africa.
WASHINGTON, Nov. 8 (Xinhua) -- NASA plans to add an unmanned flight test of the Orion spacecraft in early 2014 to its contract with Lockheed Martin Space Systems for the multipurpose crew vehicle's design, development, test and evaluation, the U.S. space agency announced Tuesday.This test supports the new Space Launch System (SLS) that will take astronauts farther into space than ever before, and provide the cornerstone for America's future human spaceflight efforts."President Obama and Congress have laid out an ambitious space exploration plan, and NASA is moving out quickly to implement it," NASA Associate Administrator for Communications David Weaver said in a statement. "This flight test will provide invaluable data to support the deep space exploration missions this nation is embarking upon."Orion is part of the now defunct Constellation program canceled under President Barack Obama's 2011 budget proposal. Instead Obama urged NASA to work toward sending humans to an asteroid and then on to Mars -- and NASA says it wants to go ahead with that as quickly as possible.This Exploration Flight Test, or EFT-1, will fly two orbits to a high-apogee, with a high-energy re-entry through Earth's atmosphere. Orion will make a water landing and be recovered using operations planned for future human exploration missions. The test mission will be launched from Cape Canaveral to acquire critical re-entry flight performance data and demonstrate early integration capabilities that benefit the Orion, SLS."The entry part of the test will produce data needed to develop a spacecraft capable of surviving speeds greater than 20,000 mph and safely return astronauts from beyond Earth orbit," Associate Administrator for Human Exploration and Operations William Gerstenmaier said. "This test is very important to the detailed design process in terms of the data we expect to receive."
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