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WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.

LUQA, Malta, Feb. 28 (Xinhua) -- Four chartered planes of China Eastern Airlines left Malta Monday, taking home 1,115 Chinese nationals evacuated from Libya. The forth Airbus A340 plane with 275 evacuees on board took off from the Malta International Airport at about 08:40 p.m. local time (1940GMT), bringing the total number of Chinese nationals back home from Malta to 2,223.The flight CES 266 with 275 Chinese nationals on board flew to Beijing while the other three will land in Shanghai, according to Chinese Embassy in Malta.Three chartered flights are expected on Tuesday, the embassy said.In the past 48 hours, three chartered cruise ship with 4,800 Chinese evacuees have reached Valletta, capital of Malta.

JERUSALEM, March 31 (Xinhua) -- Two researchers at the Hebrew University (HU) of Jerusalem have been honored with a prestigious award for their study of the connection between several inflammatory diseases, cancer and bacteria.Medical faculty members, Dr. Eli Pilarsky and Prof. Sigal Ben- Yehuda, won this year's Sir Zelman Cowen Universities Fund prize that recognizes significant achievement in the field of medicine.The prize committee noted the impressive contributions of Pilarsky and Ben-Yehuda in understanding complex diseases like cancer and antibiotic-resistant infections, and, in a first, decided to award the two scientists this year.Pilarsky told Xinhua that his research deals with the connection between chronic inflammatory diseases like hepatitis, and the development of cancer cells."The relevance of this discovery is that we were able to establish the link between the molecules secreted with such inflammations and the proliferation of cancer cells," Pilarsky explained, noting that "we discovered that the inflammation favors the cancer cells' growth, and now we are trying to find a way to manipulate these molecules to stop the cancer cells from appearing. ""The importance of these findings lies in the fact that 20 percent of the world's cancer cases are attributed to inflammation processes," Pilarsky pointed out.

SAN FRANCISCO, April 7 (Xinhua) -- Google's Android will become the most popular smartphone operating system worldwide and will account for 49 percent of the market by 2012, IT research and advisory firm Gartner said Thursday.According to Gartner's projections, worldwide smartphone sales will reach 468 million units in 2011, a 57.7 percent increase from 2010.The company predicts that Apple's iOS will remain the second biggest platform worldwide through 2014 although its share will decrease slightly after 2011, on the assumption that "Apple will be interested in maintaining margins rather than pursuing market share by changing its pricing strategy."Microsoft's Windows, driven by its partnership with Nokia, is expected to move into the mid-tier by the end of 2012 and become the third largest in the worldwide ranking by 2013.Some analysts raised doubts on Gartner's forecasts, saying that its assumption on Apple's price strategy contradicts statements by Apple's chief operating officer Tim Cook and the cooperation between Nokia and Microsoft will not have that much of an impact on smartphone market share by 2012.

BEIJING, April 14 (Xinhuanet) -- Computer sales declined in the first three months of this year for the first time since 2009 worldwide.PC sales fell 1.1 percent in the first quarter to 84.3 million worldwide, according to tech research firm Gartner Wednesday, well short of its forecast for 3 percent growth.The dip was the first since the second quarter of 2009, when most of the world was still in the grip of economic turmoil."Although the first quarter is traditionally a slow one for PC sales, these shipment results indicate potential sluggishness, not just a normal seasonal slowdown," said Gartner, in a statement.Consumers select IT products at an IT fair named "Sham Shui Po computer festival" in Hong Kong, south China, Feb. 15, 2011. The eight-day IT fair kicked off here Monday. Some 600,000 people are predicted to visit the fair.Weak demand for consumer PCs was the biggest drag on the market, according to Gartner principal analyst Mikako Kitagawa."Low prices for consumer PCs, which had long stimulated growth, no longer attracted buyers," Kitagawa said."Instead, consumers turned their attention to media tablets and other consumer electronics."After Apple's second-generation iPad was released in February, many consumers either switched allegiances or simply held back from buying PCs, according to the analyst.Japan was a particularly weak spot, with PC sales falling 13 percent in the quarter, as people focused on getting back to normal after the March 11 earthquake and tsunami rather than spending money on new technology.