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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - An order barring the federal government from deporting recently reunited parents and children who were separated at the border due to the Trump administration's "zero tolerance" policy on illegal immigration will remain in effect until further notice, a San Diego judge overseeing the case said Wednesday.U.S. District Judge Dana Sabraw, considering a request for a temporary restraining order in a case transferred from the District of Columbia, said an order he issued three weeks ago prohibiting the government from removing reunified families from the United States before they've had a chance to discuss their immigration status is still in effect for both cases.The plaintiffs in the case of M.M.M. v. Sessions got assurances from the judge that the order halting deportations applies to both parents and their children who may be seeking asylum hearings."We're asking to maintain the status quo," an attorney on the case told the judge.In June, the American Civil Liberties Union won a nationwide injunction in its class-action lawsuit requiring reunification of children separated from their parents at the border.Last week, Sabraw ordered the federal government to come up with a plan to find parents who have been deported or released back into the United States. He said it was "unacceptable" that the government had located only a few parents out of close to 500 who have been removed from the United States or released into the mainland.Sabraw ordered the government to put one person in charge of the effort to find parents who were separated from their children.The ACLU said it needs more information from the government on the whereabouts of parents who have been removed from the United States and sent mainly to Honduras and Guatemala.A status conference on the San Diego case is set for Friday at 1 p.m. 1849

SAN DIEGO (CNS) - A man was stabbed in the hands and pistol whipped in North Park Saturday after refusing to carry drugs from Mexico into the United States, police said.The victim, 49, was pressured by six friends earlier in the day to transport drugs from Mexico across the border, but he refused, said Officer Tony Martinez of the San Diego Police Department.They saw him later at 3 a.m. Saturday in the 4000 block of 30th Street, Martinez said."They got into a confrontation with him, and during the confrontation the victim was stabbed in both hands and pistol whipped," the officer said.The victim received a laceration to both hands and a laceration to the top of the head from being pistol whipped, Martinez said.The main suspect was a man known to the victim, he said. The other suspects were three men and two women. They all fled in a white Kia SUV with Mexico plates.Mid City Division detectives will be handling the investigation. 950

SAN DIEGO (CNS) - A pedestrian was fatally stuck on the Mission Valley (8) Freeway in San Diego, according to the California Highway Patrol.The crash occurred on the westbound 8 Freeway near Hotel Circle about 8:15 p.m., the CHP reported.The body was found near the center divider. There was no immediate word on the age or gender of the victim. The person's name will be withheld pending notification of next of kin.The vehicle that struck the pedestrian remained at the scene, the CHP said.The crash was blocking two lanes and the CHP issued a SigAlert at 8:35 p.m. 575

reases is wrong, as these sectors continue to do the right things, while trying to weather the ongoing pandemic and the back and forth of reopenings," Wooten's request states.Deputy Attorney General Jonathan Eisenberg, representing the state, said Wooten's conclusions were based on case numbers that have since increased and cited statements she made during a Nov. 17 San Diego County Board of Supervisors meeting, which drew a different conclusion.During the meeting, Wooten said "the numbers have expanded" since she made her request to the state."We couldn't in good conscience create that same argument since that adjudication submission was sent to the state," Wooten said while answering questions from the Board of Supervisors.Eisenberg called the recent spike in cases "an unprecedented surge" with record numbers being reached at the state, local and national level.Saying the lawsuit was based on outdated figures, Eisenberg cited a study submitted to the court which he said indicated full-service restaurants and gyms are "the top spreader locations" of virus infections.Katz argued that study was done early in the pandemic and without taking the sanitation measures businesses have implemented into account.Katz said restaurants and gyms are being punished despite adhering to the state's guidelines and said the state's reopening plan has applied its restrictions to restaurants and gyms in an arbitrary manner, which he claimed wasn't backed by science.The businesses allege in their complaint that they may be forced to close permanently if indoor operations don't resume, and that outdoor and takeout service will not make up for the economic losses incurred thus far.While Eisenberg acknowledged that businesses are suffering from "great economic hardship," he said "the balance of harms here is overwhelmingly in favor of keeping these restrictions in place."Cowboy Star Restaurant and Butcher Shop sent ABC 10News the following statement after the judge's ruling. 4120