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SAN DIEGO (KGTV) — At least six companies are working on COVID-19 vaccine candidates in San Diego, all within a 1.5-mile radius of where the I-5 and I-805 split.Locally, the farthest along appears to be Inovio Pharmaceuticals, which plans to launch a Phase 2 trial next month, potentially with a simultaneous Phase 3 trial. A Phase 3 trial is the final step in vaccine testing, with thousands of participants.The company is developing the vaccine using a DNA technique that isn’t used in any other vaccines on the market, although some are in the final stages of testing, said Dr. Kate Broderick, who leads Inovio’s vaccine program.To ensure the DNA enters a person’s cells, the company uses a proprietary device about the size of a toothbrush to deliver doses into the skin rather than a needle and syringe. The company announced Tuesday it secured a million grant from the Department of Defense to speed up production of the devices.Just down the street, TriLink Biotechnologies is working with researchers in London on a vaccine candidate that replicates itself in the body. It just started a Phase 1 trial this month.Nearby, Sorrento Therapeutics is working on both a COVID-19 vaccine and a treatment, but it hasn’t advanced yet to human trials. 10News previously featured the company’s efforts, which are based on techniques developed to fight cancer.On the other side of the 805, Arcturus Therapeutics is working with Duke University on a vaccine based on RNA, which acts as a messenger for DNA. There are no vaccines approved for humans that use this RNA approach. Trials are expected to begin in August, according to a tracker by the Milken Institute.UC San Diego is developing a vaccine using plant virus nanotechnology, leveraging an approach that’s used in vaccines against Hepatitis B and shingles. The university is also taking part in research on a COVID treatment.A spokeswoman for San Francisco-based Vir Biotechnology says the company is using its San Diego satellite office to help crunch data for the work on its vaccine, which is a collaboration with GlaxoSmithKline (GSK).GSK, Janssen, and Pfizer each have vaccine candidates of their own and offices near the 5-805 split, but 10News was not able to immediately confirm if any of those companies were conducting COVID research locally. 2318

SAN DIEGO (KGTV) -- COVID-19 related hospitalizations continue to sure across California.Without any intervention, Gov. Gavin Newsom said current projections show hospitalizations could increase two to three times the current amount in just one month.“We’ve seen a significant increase, 89 percent increase over the 14-day period of people who have been hospitalized that have tested positive for COVID-19,” Newsom said during a press briefing Monday.Hospitalizations are rising in San Diego County, with local hospitals seeing more COVID-19 cases than they ever have.“We’re seeing about three times the number that we saw just a couple of months ago,” said Dr. Omar Khawaja, the Chief Medical Officer for Palomar Health. “About 25 percent of the positive patients are ending up in the ICU; that’s less than we saw during the first spike.”Khawaja said he expects more hospitalizations in the coming weeks as COVID-19 cases related to Thanksgiving gatherings start to show up.In Escondido, Palomar Medical Center has had room to handle more COVID-19 patients from other hospitals for several months now. A federal medical station is set up inside the hospital with 202 beds that haven’t been used yet.Khawaja said they’re now ready to take on patients from other hospitals across the county that become overwhelmed, but the set-up is not meant for ICU patients.“It could be beds that we would be offload some of the less sick patients from other systems into there so they can handle the sicker patients; we don’t have a solid plan for it yet,” he said. “I don’t think it’ll be activated in the next week; it may be three or four weeks out, so we’re planning for that now.”Khawaja said the details are actively being discussed with other medical officers across the county.“The county and hospital systems are all working very well together, collaborating, communicating on at least a weekly basis. We are actively discussing right now, what would it look like, how would we open it, and what type of patients would go into there,” he said. “Are we worried? Absolutely. Is the spike coming very quickly? Yes, but we do have some capacity and redundancy available now, and we are planning to have even more."Creating more capacity could include scaling back on the number of elective surgeries scheduled, but this time Khawaja said it would look much different than what we saw months ago.“What we’ve done is essentially looked at surgeries and classified them in terms of how long can this be put off to be safe, we all saw that JUST shutting everything down just let to really, just poor patient care, and we don’t want to do that again.” 2646

SAN DIEGO (KGTV) -- Bombarded with long lines and time delays, the state is planning to replace the Department of Motor Vehicles facility in Hillcrest with a larger facility. The state would tear down the current 14,319 square-foot DMV at 3960 Normal Street, and replace it with a one-story 18,540 square-foot building. The new DMV would accommodate the 931 customers that use it daily, with 141 parking spaces. It would cost .7 million. "The existing DMV Normal Street field office is not sized appropriately to accommodate the existing staffing and service demand levels needed at this location," the DMV said in an environmental notice. But the threat of shorter wait times is not being met with enthusiasm from some Hillcrest residents.Mat Wahlstrom, a member of the Uptown Planning Group, sees the project as a missed opportunity. He pointed to a now-scrapped plan to add a mixed-use housing and retail project, plus a park. It would have a new, larger DMV on the south end the 2.5-acre site."This wouldn't be a deadzone every evening, which is what it's become," Wahlstrom said. "It was supposed to have been a dual use site."Christina Valdivia, a DMV spokeswoman, says the mixed-use plan didn't work because it doesn't conform with its vehicle-centric business model.Meanwhile, the Hillcrest Farmers Market is raising issue with the DMV's plan to add a 7-foot-tall wrought iron fence around the property. The market uses the DMV lots for parking and some of its vendors."It would really create this sort of fortress DMV that we are hostile to," said Ben Nichols, who heads the Hillcrest Business Association.Valdivia says the DMV is installing fences at all of its new and replacement buildings to protect against vandalism, theft, damage, and even human waste. Nichols said it would just push those problems onto the public sidewalk.Now, two state legislators, Sen. Toni Atkins, and Asm. Todd Gloria, are getting involved with the project. The plan is currently under environmental review. If all goes as planned, it would break ground in early 2020 and be complete by the first quarter of 2021.  2160

SAN DIEGO (KGTV) -- Coronavirus cases on the San Diego-based USS Theodore Roosevelt are multiplying quickly. On Thursday, Department of Defense officials announced 23 sailors have now tested positive for COVID-19. Officials say they have mild symptoms, fever and a cough. The aircraft carrier left her San Diego homeport in January for a seven-month deployment with roughly 5,000 sailors are on board. The carrier's last stop was in Vietnam more than two weeks ago. RELATED: New COVID-19 cases found in city where San Diego-based ship is dockedNavy closes San Diego Training Support Command after third coronavirus caseJust two days ago, the Navy announced the first three positive cases on the ship, meaning the number of infected sailors is now nearly eight times as high. The USS Roosevelt is getting ready to pull into Guam on Friday, where the positive cases will be moved off of the ship. The other sailors will be confined to the pier, not allowed to leave into Guam. Navy officials say everyone on the ship will be tested for the virus. 1052

SAN DIEGO (KGTV) - Border agents have seen a huge drop in traffic along the San Diego Sector ports of entry since the Trump Administration restricted all non-essential travel at the U.S.-Mexico border last Friday.In a conference call with reporters on Monday morning, U.S. Customs and Border Protection (CBP) revealed new details about its plan to handle the implications of the restrictions on the migrant population and the cross-border worker population. Recent tweets posted by CBP showed empty ports of entry. “We have seen about a 70% decrease on average at all our ports of entry,” said a CBP spokesperson during Monday’s conference call. That plunge in foot and vehicle traffic comes after the border restrictions took effect on Saturday.CBP said Monday that the restrictions don't apply to U.S. citizens, legal permanent residents or those traveling for medical, work or educational purposes.The agency reports that people’s work verification or documentation is currently on a sort of “honor system”. “At this point in time, we are not formally asking for verification or employment ID,” said a spokesperson on Monday.A spokesperson also reaffirmed that most apprehended migrants will be returned immediately, adding in part, “Individuals are no longer being held in detention areas.Quick interviews will be conducted in the field. Basic biographic scans run in the field as well. Then the individual will be [taken] back to the border and expelled to the country they came from.”There's now at least a 48-hour suspension on migrants crossing for court hearings, said a CBP spokesperson, who added that all new asylum seekers will be reviewed independently. “We're taking each case, case by case, depending on what the claim is, the nationality and the country from which they come from,” he added.“I'm particularly concerned about the asylum migrancy [population],” said Rafael Fernández de Castro, a U.S.-Mexico relations expert at UC San Diego. “In the shelters in Tijuana, sometimes there's 15, 20 [or even] 40 people sleeping in a room. That's basically a horrible story because that's a way to get a lot of migrants contaminated with coronavirus,” he added in his interview with 10News. CBP also reported that it’s making sure its officers have the necessary personal protective equipment like masks and gloves. 2335

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