中山为什么会便秘中山市胶囊胃镜,中山老人大便出血,中山肛门 脱出,中山哪家医院做肛瘘手术比较好,中山华都肛肠医院中午休息吗,中山华都肛泰医院治混合痔多少钱,中山肛周脓肿是怎么回事

SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459

SAN DIEGO (KGTV) — It's easier than ever to find a place to rent on a short-term basis, anywhere in the world.But this relatively new business model has touched off a whole new way of doing business for another industry: the sex trade.Law enforcement globally is reporting a rise in pop-up brothels. San Diego's Sex Trafficking Task Force calls it a form of modern-day slavery now hiding in plain sight.RELATED: Lawsuit: Contaminated stem cells from San Diego company severely sickened UFC fighter"Doing Money" is a fact-based TV Drama, which premiered at the San Diego Film Festival last month. It's bringing this issue out into the light. It tells the shocking true story of a young woman named Ana who spent nine months as a sex slave in a series of pop-up brothels in Ireland. Ana was snatched off the streets of London in broad daylight.According to statistics, that's rare. But what happened to Ana once she was in the hands of the sex traffickers, was not."Doing Money" producer Mike Dormer spoke to 10News anchor Kimberly Hunt, describing the horror Ana endured.RELATED: New CA Medical Board filing on Del Mar doctor accused of prowling"Within 12 hours she was in Ireland in a brothel," Dormer said.Dormer says Ana, and all those like her, are entrapped physically and mentally."Once they've been moved ... they have no friends, no money, no clothes, no passport, no way to escape," Dormer describes.Much like Ana’s reality overseas, U.S. Department of Justice reports reveal the victims are often kept cold, sedated with drugs, and hungry. If they don't meet their quota, they don't eat. Girls are moved by the pimps from one short-term rental to another to both evade being caught by law enforcement and to keep the girls advertised as new in town.It's happening in San Diego...The global issue of pop-up brothels is alive and well in San Diego. Deputy District Attorney Carolyn Matzger, of the San Diego Sex Trafficking Task Force, confirms it's happening locally. Last year alone in San Diego, human trafficking was an 0-million industry."We have it going on in massage parlors, hotels ... and we also have it going on in short-term vacation rentals, apartments, condos, and homes," Matzger said.The task force has busted a pop-up brothel operating out of an upscale condo in Mission Valley. Two people were convicted of pimping and pandering and an adult was rescued. She had been trafficked to San Diego from the east coast through Los Angeles. The heads of the operation were prosecuted in Orange County.RELATED: SD whistleblower reveals threat of gun reporting 'loophole' for mentally ill service membersA member of the task force who was there for the take down says it was run by professionals."It was a fairly sophisticated criminal organization. They had two people inside running the computers and security portion of it," the member said. We are not identifying the task force member. "They had a call center, they would give the johns a code to enter the building."He says it all starts on the internet where the girls are advertised for sex. After a john schedules a hook up, he'll get the location."They'll get directed to go to a brothel whether that's a condo or an Airbnb," the task force member says.RELATED: City may weigh 'vacancy tax' targeting empty homesUnlike guns and drugs which can only be sold once, a person can be sold over and over again. Matzger says the girls are expected to bring in the bucks."Ten times a day. Ten times a night. They work all night long," Matzger says.And they're isolated and totally under the fist of her traffickers"She's dependent on them for where she sleeps, what she eats, when she eats, and when she sleeps. That's what we see here in San Diego," Matzger adds.RELATED: La Jolla party house scene of violent attack, mother saysMatzger says the traffickers demand the girls understand who they belong to.Taking on traffickers...Ana testified against her traffickers in the United Kingdom. They were convicted and sentenced to three years.Her testimony helped secure the passing of the first Human Trafficking and Exploitation Act in the U.K in over a hundred years. Experts say we have a long way to go and statistics back that up. Worldwide, almost five million women and girls endured forced sexual exploitation last year.In San Diego, the Sex Trafficking Task Force — a combination of positions from members of the DOJ, the San Diego District Attorney's Office, and San Diego Police Department — has created an aggressive front taking on sex trafficking in a county that attracts it because of tourism.Matzger says, "large gatherings such as Comic-Con, sporting events, and other venues that attract tourists ... also attract those looking to buy sex." 4736

SAN DIEGO (KGTV) - It's a nervewracking place: on stage, behind the mic, looking out at a sea of people waiting for your punch line.The Comedy Palace in Kearny Mesa sees many comedians but not like the one who performed Friday night."It was something I thought about even in college but lacked the courage to do it," said Michael Schmid. "I always loved to make people laugh."Schmid always had the passion, but it was a recent visit to the doctor that gave him the courage he had been lacking."If not now, when," Schmid said.Three years ago, he was diagnosed with primary lateral sclerosis, a condition similar to ALS."It had spread to my upper body and becoming more quadriplegic," Schmid said.One month ago, he made the toughest decision of his life."The most difficult thing I ever had to do in my life was to talk to my children about ending my life."Schmid says he will end his life on December 27, citing severe pain. He shared the date with one of his favorite comedians, along with a dream and a request for help."My initial response was 'We're going to make this happen,'" said Lisa Alvarado.Alvarado talked with some friends in the industry to see if they'd help make Schmid's dream of performing come true."I'm talking comics with Netflix specials, Comedy Central specials," Alvarado said.In one month, the group developed a 15-minute standup comedy routine for Schmid to deliver Friday night. Many of the professional comedians were in the audience as Schmid performed in his wheelchair with Alvarado holding his microphone.After the performance, Schmid's father made his way to the stage to give his son a hug."I never expected him to do that and show the world we're close," said Schmid.Schmid's ex-wife and his four children were also in the audience."No matter how crappy of a hand he's been dealt, he's taken it with a joke," said Schmid's son Joshua.Schmid is grateful he had a chance to laugh."I want my friends and family to have at least that memory when I'm gone," Schmid said. "Do not just give up where you're at...always strive and reach for something else.""Even if it is the end of your life, you can be more than you are right now." 2188

SAN DIEGO (KGTV) — It's the perfect weekend to celebrate your loved ones at events around San Diego County this weekend.The San Diego Automotive Museum hosts a walk back to the 1970s for a look at the evolution of cars with That 70s Car Show, a new exhibit showing how the 70s fueled today's industry. Plus, all February is Museum Month, giving locals the chance to visit participating museums of half-off admission.Valentine's Day dinners will headline Friday night for many across San Diego and thankfully there are plenty of places with a view and delicious meals to match.MORE: Don't see anything you like? Check out our event calendar for even more local eventsMonster Jam returns to Petco Park this weekend for more monster truck madness across dirt ramps. Brick Fest Live! brings millions of LEGO bricks to Del Mar with hands-on activities and exhibits to see.Here's a look at this weekend's events:THURSDAYThat '70s Car ShowWhere: San Diego Automotive Museum; Cost: - (Thursday - Sunday) Check out the defining era of automobiles that was the 1970s in a new exhibit at the San Diego Automotive Museum. From social changes to political upheaval to technology, the 70s had a profound impact on the automotive industry and U.S. manufacturing. See how the past's innovations fueled what we drive today.Oceanside Sunset MarketWhere: Tremont and Pier View Way; Cost: FreeEvery week, residents head down to Pier View Way to enjoy Oceanside's Sunset Market, giving visitors the chance to enjoy the scenic sunset alongside delicious foods and desserts, live entertainment, and local shopping. More than 200 merchants span four blocks, boasting an array of fun, unique, and delicious finds. The free market also features fun for kids with a special "KidZone" packed with activities.FRIDAYValentine's Day dinnersWhere: Various locations; Cost: VariesYou've got the flowers ordered, the gift ready, but have you found a place for that romantic dinner? Take your sweetheart out to a romantic Valentine's Day dinner in San Diego — where there are plenty of special dinners and views to match planned for the evening.Mingei pop-up workshop: We Heart ArtWhere: The New Children's Museum; Cost: Free - .50Mingei International Museum hosts a special Valentine’s Day pop-up with Mexican folk and heart-inspired art. Create a “milagro” folk charms or decorative items for yourself or as a gift for your love this Valentine's Day!SATURDAY5K Paw Walk in the GardenWhere: San Diego Botanic Garden; Cost: - Take your four-legged friends to the San Diego Botanic Garden to help raise funds for Rancho Coastal Humane Society. Pets will get to take a nice, scenic walk though the 37 acre garden, enjoy treats, and hang out with other canines. Adults can check our pet products and enjoy some treats themselves.Monster JamWhere: Petco Park; Cost: Starting at Monster Jam will tear up dirt and mud at Petco Park, bringing monster truck drivers to town to jump, flip, and fly across the park in head-to-head competitions and to wow fans. Pit party tickets get fans up-close access to their favorite drivers and cars, the chance to get autographs, take photos, and more fun activities.Brothers Keeper Music FestivalWhere: Booze Brothers Brewing, Vista; Cost: Hang out at Booze Brothers in Vista for their Brothers Keeper Music Festival, featuring performances by San Diego's The Schizophonics, Sacri Monti, Dani Bell & The Tarantist, Volcano, and more.SUNDAYBrick Fest Live!Where: Del Mar Fairgrounds; Cost: (Saturday - Sunday) Brick Fest Live! brings thousands of magnificently built LEGO models to the Del Mar Fairgrounds, with hands-on attractions and activities geared to inspire and educate guests to create. The event features a Guinness World-record setting mosaic, video game arena, a LEGO speedway, life-sized builds, and more.WinterfestWhere: Point Loma Community Presbyterian Church; Cost: FreeJoin PLCPC for some winter magic at their Winterfest. The event features a bounce house for kids, hot chocolate bar and snacks, crafts, bingo, an indoor snowball fight, a winter movie, snow, and more.Museum MonthWhere: Various locations; Cost: Prices vary(Saturday - Sunday) Throughout the month of February, San Diegans and visitors can pick up a special, free pass to save 50 percent at more than 40 museums throughout the city. Museums like the Fleet Science Center, Maritime Museum, San Diego Air & Space Museum, Natural History Museum, and many more are participating in the special month. 4517

SAN DIEGO (KGTV) -- If you're planning a trip to cast your ballot at San Diego's Registrar of Voters or one of four satellite polling locations, check out the ROV interactive wait time map below. 203