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WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."
BEIJING, July 26 (Xinhuanet) -- The breast cancer is more deadly to black women than to whites, a new study found.This finding was published online Monday on the "Journal of Clinical Oncology" in the United States.The study was done by the City of Hope, a Comprehensive Cancer Center in Duarte, California.The researchers collected data from more than 4,500 U.S. women in the 35-64 age group who were diagnosed with breast cancer.With the passing of more than eight years, the researchers found the black women have a three times death rate than white women, after taking obesity and other diseases into account."It’s been long known that breast cancer in African-American women is a far less common disease than in white women. But when it occurs, it seems to be more aggressive and harder to treat," said Dr. Lisa Carey of the University of North Carolina’s Lineberger Comprehensive Cancer Center.But why the situations varied by race, scientists are still exploring the answer.
BEIJING, July 5 (Xinhuanet) -- A black iPhone 4 prototype has appeared for sale on eBay and the highest bidding hit one million U.S. dollars as of Monday, according to media reports.The listing is set to expire on July 11.The seller "jtmaxo" said, "I am a licensed cell phone repairman, this iPhone was bought from a person who really didn't know who he had."The seller later was frustrated to find that it was unable to be activated via iTunes.According to a check through Apple’s database, it is indeed listed as a prototype, and it has the tester code "DF1692" etched in the bottom right corner.Different from the iPhone 4 sold on markets, the handset lacks the + and - on the volume buttons, although the screen is fully functional.The price for the prototype will not remain as high as it is as the seller said that several "non-legitimate" bids have already been deleted.
LOS ANGELES, Sept. 10 (Xinhua) -- Scientists at the University of California Los Angeles campus have announced that they have successfully used new prediction algorithms to forecast climate up to 16 months in advance.Professor Michael Ghil said in a UCLA news release Friday his team used new prediction algorithms based on matching ocean temperature records with new theories on how long-term climate trends are influenced by short-term weather extremes.That's twice as far into the future as previously accomplished.Ghil, a distinguished professor of climate dynamics in the UCLA Department of Atmospheric and Oceanic Sciences and senior author of the research, said the new prediction formulas will give climate experts and governments clues about long-term swings in the El Nino/La Nina oscillation in the Pacific Ocean, which drastically affects weather in the Americas, Asia and Australia.The new forecasting tool uses sea temperatures and has been tested on decades of historical data. The forecasts were then cross-checked against actual climate trends.The UCLA team also said that their 16-month forecasts were more accurate than previous forecasts that went only 8 months forward.Ghil emphasized that the forecasting tools are for climate, which is long-range, global patterns, but not for meteorology, which is short-term weather forecasting."Certain climate features might be predictable, although not in such detail as the temperature and whether it will rain in Los Angeles on such a day two years from now," said Ghil, who is also a member of UCLA's Institute of Geophysics and Planetary Physics. "These are averages over larger areas and longer time spans."The study is currently available online in the journal Proceedings of the National Academy of Sciences (PNAS) and will be published in an upcoming print edition of the journal.
HELSINKI, Aug. 21 (Xinhua) -- The Finnish company Spektikor has recently developed a novel type of disposable heart rate indicator, local media reported on Sunday.Different from a conventional heart rate monitor, it is a speed heart rate indicator designed for first aid professionals and specially used in first aids in major accidents, disasters and other crises.According to Spektikor, the product is consisted of a heart rate sensor with two EKG electrodes and a LED indicator, which are connected by a 35-cm-long wire.In operation, the sensor is placed on a patient's chest and the LED indicator is sticked to the patient's cheek. If the heart rate is within the normal range, the LED indicator will flash green with each beat. If the heart rate is dangerously low or high, the light will turn red.The product will help hospital staff speed up their work considerably as it is not necessary to check the pulse manually. In addition to saving time, it will also enhance safety, as the LED indicator can be seen clearly at a glance.The market prospect of the disposable heart rate indicator is quite optimistic as there is a worldwide need for the product.