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Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

CARMEL VALLEY (KGTV) - A man threatened to shoot a clerk at the Everbowl in Carmel Valley and ran away with cash on Saturday night, San Diego Police said.According to police, an armed man entered the restaurant shortly before 6 p.m. and demanded cash. The clerk gave him an unknown amount of money, and the suspect ran away.The suspect was last seen running through the parking lot. He is described as a white man, 30 to 40 years old, about 5' 11" tall with a medium build. He was unshaven and wearing a blue hooded jacket, dark beanie and jeans.Anyone with information is asked to call San Diego Police. 617

CARLSBAD, Calif. (KGTV) - On a given evening, the streets of Carlsbad Village are filled with people walking, biking, and driving across the train tracks that bisect the city.The number of trains passing through has also been steadily increasing.“There are projections that say in the next 10 years train traffic is going to double through this region,” said Jason Haber, who works for the City of Carlsbad.Carlsbad Village is one of the last remaining stretches of train tracks along the San Diego Coast that has not been double-tracked to accommodate the growth in train volume. But there are plans to change that.The option being pushed by the city is to trench the tracks through the downtown area. That would also address the other pressing issue on the tracks: safety.In the last 5 years, the North County Transit District says 11 people have died from being struck by a train in the city.Last September, Jason Holsinger was killed where the tracks cross Grand Avenue when he rode his bike passed a lowered crossing arm.Near Tamarack Avenue, Josh Foster was killed last February while walking along the tracks. The Medical Examiner determined he had marijuana in his system but ruled it an accident.One of the most high profile deaths occurred in 2014 when 22-year-old Patrick Terrin was struck by a train while crossing at Grand Avenue after a night of drinking.The family sued the City of Carlsbad and BNSF railways claiming there were inadequate safety measures at the crossing for pedestrians. However, they lost the case when a judge determined the city and BNSF were not liable.If a plan to trench the tracks is given the green light, the vehicle and pedestrian crossings would go over the tracks.Two alternatives are currently being looked at, a shorter and longer version.The North County Transit District oversees the tracks in the area and would end up making the end decision. It’s unclear where the money would come from at this point. Depending on the alternative chosen, the project could cost between 300-400 million dollars. Construction could take several years. 2093

Cape Town may have narrowly avoided Day Zero -- the date at which the South African coastal metropolis of 4 million people would run completely out of water -- but the extreme water crisis it's facing is far from over.Draconian water restrictions remain on the city's residents, limiting their water usage to 50 liters a day per person, and if significant winter rains do not replenish the region's reservoirs, Cape Town will once again be faced with prospect of taps running dry in early 2019.With desalination efforts proving to be time-consuming and costly, unconventional water supply options are under consideration. 629

CARLSBAD (KGTV) -- A San Diego couple is missing their cruise over coronavirus concerns after they say the cruise company changed the itinerary without a refund.Lisa and Luis Revilla are cruise ship connoisserus. They've sailed through the Greek Islands and along the Italian coast. Their next trip was supposed to be through the Pacific Islands on the Norwegian Jade. But, due to coronavirus concerns that ship set sail without them. RELATED: Second case of coronavirus confirmed in San Diego County"I don’t need to go and risk my life," said Lisa Revilla. "We were sailing from Singapore and were being dropped off in Hong Kong. Hong Kong in the end closed their port."So, Norwegian changed the itinerary to leave Singapore, spend time at sea and head back to Singapore. It also wouldn't be your typical trip. "They were gonna implement certain temperature gauges, every time we got off and got back on from every port we were traveling to," said Revilla. RELATED: Mislabeled sample led to release of San Diego coronavirus patientBut to get over there they were planning on flying from LAX to Hong Kong, but American Airlines canceled their flights. So, they couldn't have taken the cruise even if they tried. "Basically I'm out almost ,000 from this voyage we were going to take," said Revilla. "What if we’re quarantined and I cant get back to my job I mean who’s going to pay for that?"Norwegain sent us this statement:“We always strive to do right by our guests while maintaining the business policies and practices we have in place to help us manage through situations just like this. It is because of the very nature of unexpected situations that we strongly recommend that guests obtain travel protection insurance. As a convenience to our guests, we offer a few travel protection plans at the time of booking, as well as during several follow-up communications. The plans allow for coverage in many situations. Some plans offer guests the opportunity to cancel for any reason. In addition, as is common in the travel and tourism industry, we have developed cancellation policies.They are communicated to our guests at time of booking and can be found on our website here: https://www.ncl.com/sites/default/files/Guest_Ticket_Contract_04-2017_2.pdfRevilla told 10News they were traveling with another couple who even purchased insurance through Norwegian and were told it wouldn't apply here. "We’ve been saving our money for a whole year and planning this whole trip. And it just didn’t happen," said Revilla. RELATED: Child returns to hospital after showing possible coronavirus symptomsRevilla was able to get the money from her flights refunded as well as a hotel they had booked in Hong Kong. 2716