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Could the no-calorie sweetener you rely on to replace sugar in your diet actually cause weight gain instead of the weight loss you were expecting?The answer may be yes, according to a new study."Artificial sweeteners are not risk-free," said Brian Hoffmann, assistant professor in the Department of Biomedical Engineering at the Medical College of Wisconsin and Marquette University, and a lead author of the study. "They are a very controversial topic when it comes to health and nutrition ... but they're so prevalent in society that I think we owe it to ourselves to try and figure out what's actually going on."Hoffmann presented his new research Sunday at the annual?Experimental Biology meeting in San Diego. Relying on rats and human cell cultures, his team identified a number of pathways linking artificial sweeteners with metabolic changes at the genetic level that could lead to diabetes and obesity. Specifically, the researchers found that three weeks of exposure to aspartame and acesulfame potassium -- two artificial sweeteners frequently combined in products such as Equal -- altered the expression of certain genes responsible for lipid metabolism in the cells of both rats and humans."Aspartame had some significant changes, and one of those was an increase in lipids in the bloodstream and a decrease in a biomolecule that is involved in clearing (lipids) from the bloodstream. And we saw the exact same thing with the acesulfame potassium," Hoffmann said."We then took those particular sweeteners and put them on endothelial cells -- the cells that line the blood vessels and would be exposed to them in the body -- and we detected a marked dysfunction, suggesting why sweeteners and diet soda have been linked to potential cardiovascular problems," he added.What was perhaps most surprising, according to Hoffmann, was that these metabolic changes did not occur in the presence of natural sugars such as glucose and fructose. This suggests that artificial sweeteners could contribute to metabolic disorders such as diabetes and obesity by an entirely different mechanism than natural sugars, he said.Artificial sweeteners appear to contribute to metabolic disorders by altering the activity of certain genes responsible for the breakdown of macromolecules such as fats and proteins, Hoffmann said. This is different from normal sugars, which contribute to cardiovascular disease through insulin resistance and by damaging the cells lining the body's blood vessels."People are generally consuming non-nutritive sweeteners believing they are a 'healthy choice,' but this may not be true," said research scientist Meghan Azad of the University of Manitoba in Winnipeg, who was not involved in the new study."This is especially important given the widespread and increasing consumption of artificial sweeteners in the general population and the increasing use of artificial sweeteners in our food supply," said Azad, who has authored a paper that reviewed a number of studies on the potential downside of artificial sweeteners on weight and health.According to Azad, over 40% of adult Americans consume no-cal sweeteners on a daily basis, and studies that measure the sweeteners in blood and urine show that many people who report not using artificial sweeteners are unknowingly consuming them.It's the latest assault in the ongoing debate over artificial sweeteners and their impact on health -- a debate that began when one of our most popular foods, sugar, turned sour in terms of health. 3527

Considered one of the top architectural marvels of all time, the Great Wall of China draws millions of travelers to its fabled stones every year.Earlier in August, home rental website Airbnb launched a new contest called "Night at the Great Wall," in which four people and their guests would have got the chance to sleep in a custom-designed "home" set in one of the UNESCO-listed structure's towers.Judging by the photos of the set-up provided by Airbnb, the once-in-a-lifetime experience would have been quite spectacular -- but not everyone thought it was a good idea.Airbnb received mixed feedback on the concept -- amidst concerns that the competition could cause damage to the famous wall."We deeply respect the feedback we have received," said Airbnb in a statement. "We have made the decision to not move forward with this event." 846

Click here to learn how you can donate to help Bonita Vista High School repair the damage caused by recent flooding to the Bolles Theater, as well as equipment and wardrobe. 181

COOK COUNTY, Illinois (AP) — A Michigan woman has been charged with murder in the deaths of her newborn twin sons more than 17 years after their bodies were found near Chicago.Authorities said Saturday that 41-year-old Antoinette Briley of Holland, Michigan, has been charged with two counts of first-degree murder for the deaths of her sons.The boys’ bodies were discovered on June 6, 2003, by a waste management employee who was emptying trash bins in Cook County, Illinois. Officers say the worker spotted the bodies in the front lift bucket.“A subsequent autopsy determined the victims were born alive and died of asphyxiation and the deaths were ruled homicides,” said Leo Schmitz, Chief of Public Safety at the Cook County Sheriff's Office, during a press conference.Using DNA technology, detectives eventually identified Briley as the victims’ potential birth mother.As part of their investigation, Schmitz says detectives traveled to Michigan and “obtained discarded items with Briley’s DNA,” which was then matched to the DNA of the newborn victims.On Thursday, officers say they learned Briley was in the Cook County area and took her into custody after a traffic stop in Oaklawn, Illinois. The suspect was transported to the sheriff’s headquarters, where Schmitz says she admitted to the “birth, death, and disposal” of the infants. 1351

CORONADO (KGTV) - Friends gathered to mourn Navy sailor Curtis Adams Saturday night, who was killed while trying to help what he thought was a stranded driver on I-15 last week.His friends told stories on Breakers Beach at Naval Air Station North Island about how he loved cars, was a goofy basketball player and how he always made sure his hair was in place. They said that he was exactly the type of guy to pull over to help somebody in need.They released lighted balloons by candlelight to honor the 21-year-old sailor from New York.Brandon Acuna, 21, was arrested for Adams' murder. He is accused of shooting Adams after Adams stopped to help him on the side of I-15 near I-5.Acuna pled not guilty in his arraignment on Wednesday. He is due back in court on November 9.   803

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