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SAN DIEGO (KGTV) - The Coronado Police Department released an image Monday of a vehicle that may be related to BB gun incidents in Coronado Sunday. 10news has learned five people were struck in the downtown area. Police spent the morning scouring the ground near State Street and West Broadway. An officer told 10news four people were crossing State Street late Saturday night or early Sunday evening when three of them were hit. The extent of their injuries are unknown. At the corner of L Street and Sixth Avenue in the East Village, a woman was shot in the arm early Sunday morning, according to San Diego Police. She was walking in a small group and one of the men was an exhibitor at Comic Con, staying at the Omni Hotel, where they were headed before the shooting. The early morning shooting was not the only one that occurred overnight. In National City and Paradise Hills, at least a dozen cars were hit, and in Coronado, police said at least 23 businesses, homes an cars were struck by BBs.10news brought the image of a white sedan released by Coronado Police to Roman Beck, who has worked as an accident reconstruction expert for two decades."I believe it's a 2005 to 2010 Chrysler 300 sedan. It has the front, passenger and rear windows scrunched and a flattened roofline, along with similar roof structures and a flare around the wheelwell," said Beck.Coronado Police are asking anyone with surveillance cameras to check Sunday, July 21 from 1:30 a.m. to 2:30 a.m. Anyone with any information is asked to call (619) 522-7350.The rash of crimes comes after 10News reported more than a dozen businesses and car windows busted by BBs in the past month:June 24th – Numerous vehicle windows were vandalized in the Point Loma, Ocean Beach and Mission Hills neighborhoods.July 1st and July 2nd - Three businesses in the Hillcrest neighborhood were vandalized.July 2nd - Two businesses in the Park West neighborhood were vandalized.July 2nd and July 3rd – Numerous vehicle windows were vandalized in the Clairemont neighborhood.July 6th - Three businesses and one vehicle were vandalized in the Midway area. A dark colored SUV is suspected in these cases.July 7th - Five businesses in the College area were vandalized.July 8th - One home in the Lake Murray neighborhood was vandalized.July 21 - A woman was shot in the arm with a BB gun L Street and Sixth AvenueJuly 21 - Nearly two dozen businesses, homes and cars hit throughout CoronadoJuly 21 - Eight cars damaged on the 5800 block of Altamont DriveJuly 21 - Four cars damaged near East Plaza Blvd and Olive in National CityAccording to California law, negligent discharge of a BB gun resulting in injury could mean up to a year in jail.Police from the corresponding agencies are working on these cases. If you have any information or surveillance video, please contact your local department. 2862

SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) - Sunday, doctors revealed President Donald Trump is taking a steroid, called Dexamethasone, as the latest medication for his coronavirus treatment."We just don't know what's going to happen next, things are very unpredictable," Dr. Christian Ramers, Chief of Population Health at Family Health Centers, said.Ramers has seen thousands of COVID-19 patients and says the disease has two phases, virus production and inflammatory. He said the shift generally happens seven to ten days in."Once things kind of shift, the damage actually comes more from the immune system's response than the virus itself," Ramers said, which is why a steroid like Dexamethasone is prescribed."Where it showed a decrease in mortality was in people who already required oxygen or if they were even sicker than that and were on ventilation," said Ramers, citing a study.Sunday, doctors stated the president received oxygen Friday before being taken to Walter Reed Medical Center, but said his oxygen levels only dipped to 94% and 93%. Normal levels are 95% and above.Ramers said studies show if you give the steroid too early or to someone who has a mild case, it could cause harm. "If you dial down the immune system too early or in a case that is really mild, you might have the opposite effect you're looking for," Ramers said.There's also a list of side effects."If you use them for a chronic basis or for more than a couple of days there is a long list of things it can cause. They can make your bones thinner, it can give you high blood sugar, diabetes, it can make people have trouble sleeping," Ramers said.With the president, as in any case, Ramers said we need to keep watching, "watching very carefully to what's happening day by day, it's going to be very important especially in this 7-10 day period because things could take a turn at any moment."Ramers said there are experimental coronavirus drug trials coming to San Diego, click here for more information or to sign up. 1988

SAN DIEGO (KGTV) - The family of a man reported missing from a Spring Valley care facility two weeks ago told 10News Friday he was found safe in North Park.Aldofo Otanez, who has schizophrenia, lived at Mi Casa es Su Casa. His family said he was planning to visit his brother on February 16 but never arrived.Otanez’ brother said the family passed out flyers and posted pictures on social media.RELATED: Schizophrenic man still missing after two weeksOn Friday, a 10News viewer called the family to say Otanez had been sleeping on the sidewalk on El Cajon Blvd. in North Park.People at Dave’s Flower Box had given him a bottle of water, money to buy coffee, and a burrito.The family says he was hungry but is doing well. 738

SAN DIEGO (KGTV) — The “lip sync challenge” is the gift that keeps on giving.The public gets to see local law enforcement bust a move and agencies are able to let loose a little for some community engagement.Here’s how it works: A law enforcement agency is prompted to take the challenge. They select their song or songs and put together a video lip singing the lyrics. That agency then challenges another agency and so on.RELATED: California Highway Patrol takes on 'lip sync challenge' in six-minute music videoNow, San Diego Sheriff’s deputies are tossing their skills into the mix.In a video posted to YouTube this week, SDSO took the challenge issued by their colleagues at Orange County and Los Angeles Sheriff’s Departments.Sheriff Bill Gore and a host of deputies and department employees bust out “Best Day of My Life” by American Authors.Check out the three-minute music video by San Diego deputies: 922

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