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The US Food and Drug Administration approved Janssen Pharmaceuticals Inc.'s esketamine on Tuesday for treatment-resistant depression; the drug is the chemical cousin of ketamine, the powerful anesthetic that has been used illegally as the club drug Special K.It will be sold as Spravato. More specifically, it's for patients who have tried at least two other medications without success, and it should be taken with an oral antidepressant."There has been a longstanding need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition," Dr. Tiffany Farchione, acting director of the Division of Psychiatry Products at the FDA's Center for Drug Evaluation and Research, said in a 745

Trump orders rapid withdrawal from Syria in apparent reversal19 DEC 18 10:23 ETBy Barbara Starr and Ryan Browne, CNN    (CNN) -- Planning is underway for a "full" and "rapid" withdrawal of US troops from Syria, a US defense official told CNN Wednesday.The decision, which would be a reversal from previously stated US policy, was made by President Donald Trump, who has long signaled his desire to get out of Syria, the official added.On Wednesday morning, the President tweeted, "we have defeated ISIS in Syria, my only reason for being there during the Trump Presidency."Even though the US will continue to maintain troops in Iraq with the capability of launching strikes into Syria, a US withdrawal of ground forces would fulfill a major goal of Syria, Iran and Russia and risks diminishing US influence in the region.The US has about 2,000 troops on the ground in the country, where they are primarily training local forces to combat ISIS. The US-backed and Kurdish-led Syrian Democratic Forces have had some recent success against the terror group and are on the cusp of capturing the last major town held by ISIS east of the Euphrates.Estimates vary as to how many ISIS fighters are left in Syria. In the town of Hajin, the terror group's last redoubt, the coalition estimated some 2,000 ISIS fighters were present. But a Defense Department inspector general report put the number of ISIS members in Syria and Iraq as high as 30,000.The US has forces in Iraq ready to launch attacks in Syria if necessary. In the last few weeks, the US-led coalition fighting ISIS has carried out hundreds of air and artillery strikes targeting ISIS in Syria. Some of those strikes were launched from neighboring Iraq, where the US has over 5,000 troops. Hundreds of US troops have also been training local forces at At Tanf in southern Syria, where Russia-backed pro-regime forces are seeking to oust the US presence.Pentagon spokesman Col. Rob Manning told CNN that, "at this time, we continue to work by, with and through our partners in the region."The US-led coalition recently denied any change to the US presence in Syria."Any reports indicating a change in the US position with respect" to the US military presence in Syria "is false and designed to sow confusion and chaos," the coalition said in a statement earlier this month.Gen. Joseph Dunford, the chairman of the Joint Chiefs of Staff, said this month that the US needed to train thousands of local fighters to ensure a lasting defeat of the terror group.US forces were recently directed by Secretary of Defense James Mattis to establish observation posts along the Syria-Turkish border as part of an effort to reduce tensions between Turkey and America's Kurdish allies in the fight against ISIS.News of the planned withdrawal was 2818

TUCSON, Ariz. — Arizona geography teacher Scott Warren is on trial for being accused of giving two migrants temporary shelter in the Sonoran Desert. But Warren’s arrest hasn’t stopped humanitarian organizations from continuing to help those who need it.One of those organizations is Humane Borders.“The whole idea of Humane Borders is to save lives,” said Steve Saltonstall, a 75-year-old volunteer and retired trial lawyer in Tucson. He drives into the Sonoran Desert often to fill water tanks that Humane Borders has scattered across Southern Arizona for those who need it.“The desert is an extremely harsh environment,” said Joe Curran with the Tucson Sector of the U.S. Border Patrol. “You’re just surrounded by absolute, desolate nothing. There’s no water out here, there’s minimal cellphone reception.”On this specific Friday, Saltonstall and other volunteers met at 6 a.m. to check a route of water tanks west of Tucson.“We go to each water station and fill it if need be, if the station is vandalized, we’ll replace the barrel,” he said. Salntonstall explained that sometimes people will put arsenic or gasoline in the barrels, so the water has to be tested often. He's also seen bullet holes in barrels.The organization has these in place mainly for people traveling north from the U.S.-Mexico border.Over the years, Humane Borders and the Pima County Medical Examiner’s Office have put together a death map which shows where more than 3,000 people crossing the border have died since 2000.“We consult those maps and try to put water stations where people have been found dead,” Saltonstall said. “It’s not easy walking, especially at night when people walk a lot to try and avoid the Border Patrol.”The Border Patrol has implemented their own initiatives to help those in distress — solar-powered safety beacons. These beacons have a button on them that notifies Border Patrol that someone needs help.“It could just be an average citizen in distress but a majority of what we see are illegal immigrants,” Curran said. “We have 34 of (the safety beacons) across Tucson sector.”The Tucson sector spans more than 250 miles in the Arizona desert.“We’re gonna make sure everyone has water, food and everybody is medically evaluated," Curran said.In 2018, the agency rescued more than 140 people at beacon locations.According to Curran, if you come across someone in the desert, the best thing to do is offer them water if they need it, and contact the proper authorities.But what happens next for those who are found in the desert depends on their citizenship status.“These are acts of desperation,” said Maurice Goldman, a Tucson immigration attorney.Humanitarians and other people who help those migrants, like Saltonstall and Humane Borders, also face a certain risk.“Most of these individuals that are out there doing this good work are aware that there is that risk,” Goldman said. “The government could bring charges against an individual for assisting or harboring an immigrant or migrant.”The number of people the government is actually prosecuting for that is also on the rise.As of November 2019, there have been more than 5,700 prosecuted cases, a 27% increase over 2018, according to the 3217

The Supreme Court could now decide as early as Wednesday afternoon whether an unnamed foreign-owned company will have to pay daily fines for avoiding a grand jury subpoena related to Robert Mueller's special counsel investigation.The company submitted a reply under seal to the Supreme Court earlier today, following written arguments it and the Justice Department made last week.The filing Wednesday tees up a vote by the full Supreme Court.The company has been trying to avoid a subpoena from a DC-based grand jury, and faced court-imposed fines for every day it did not turn over information.After losing at an appeals court, the company took its challenge to the Supreme Court and asked for a freeze on the mounting penalties.Chief Justice John Roberts allowed it a temporary pause last month, but the full court is now expected to weigh in on whether the freeze should stay in place.A denial from the court would be an apparent win for Mueller's team. Grand jury matters in the federal court system are typically kept secret, unless a witness decides to speak about the subpoenas they receive or their experience testifying.However, the case has still been one of the most secretive in years to progress through the court system.It apparently included two face-offs between special counsel office prosecutors and the unnamed company's private attorneys.After losing at the trial level, the DC Circuit Court closed a floor of the courthouse during appellate arguments to keep the identities of the arguing attorneys completely under wraps.The company has kept nearly all its filings secret -- with the exception of a log of when it submits information to the appeals courts.Though the Supreme Court allows for cases like this to be secret in their early requests, the high court has never heard a known case where all parties and arguments stayed confidential. 1907

TOKYO (AP) — Japan's Olympic minister says the contract to hold the Tokyo Games only specifies the event has to be held during 2020. Seiko Hashimoto's response to a question in the upper house of parliament implies the Olympics could be held later in the year and would not have to start on July 24. Hashimoto told parliament on Tuesday that “the IOC has the right to cancel the games only if they are not held during 2020.”“This can be interpreted to mean the games can be postponed as long as they are held during the calendar year,” said HashimotoHashimoto's comments come amid growing concern that the International Olympic Committee (IOC) could be forced to cancel the games due to the ongoing outbreak of COVID-19, the upper-respiratory disease caused by the 2019 novel coronavirus. More than 3,100 have died from the disease worldwide, with a majority in mainland China. At least deaths have been reported in Japan, according to a tally by 959