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The next full moon will appear in the sky this weekend. The full moon will appear “opposite” the sun at 5:17 p.m. EDT Sunday and it will appear full from Saturday morning to Tuesday morning, 203

The 2019 Nobel Prize for Medicine has been jointly awarded to William Kaelin Jr., Sir Peter Ratcliffe and Gregg Semenza for their pioneering research into how human cells respond to changing oxygen levels.Announcing the prize at the Karolinska Institute in Stockholm on Monday, the Nobel committee said that the trio's discoveries have paved the way for "promising new strategies to fight anaemia, cancer and many other diseases."The 2019 medicine laureates, the committee added, have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.The importance of oxygen has long been established, the committee explained, but how cells adapt to changes in its levels remained unknown.Randall Johnson, prize committee member, described the trio's work as a "textbook discovery.""This is something basic biology students will be learning about when they study, at aged 12 or 13, or younger, biology and learn the fundamental ways cells work. This is a basic aspect of how a cell works and, from that standpoint alone, it's a very exciting thing."The winnersNew York-born Kaelin established his own research laboratory at the Dana-Farber Cancer Institute in Boston and became a full professor at Harvard Medical School in 2002.Semenza, also born in New York, became a full-time professor at Johns Hopkins University in 1999 and since 2003 has been the Director of the Vascular Research Program at the Johns Hopkins Institute for Cell Engineering.Ratcliffe, who was born in Lancashire, England, studied medicine at Cambridge University and established an independent research group at Oxford University, becoming a full professor in 1996. 1694

THE HAGUE, Netherlands – Dutch YouTube celebrity Nikkie de Jager has come out as transgender, saying she decided to discuss her gender identity publicly after being blackmailed. De Jager posted a video on her makeup advice channel NikkieTutorials late Monday in which she described coming out as liberating. By Tuesday afternoon, the video had been viewed more than 16.5 million times. De Jager said she'd always planned to share the information with her followers, but never found the right time and in the end, blackmailers forced her hand. “It was frightening to know that there are people out there that are so evil that they can’t respect someone’s true identity," she said. 691

The Federal Aviation Administration has halted all flights in and out of Chicago's O'Hare Airport — one of the nation's busiest — due to a sprawling winter storm. The alert on the agency's website said the stop would last at least through 9 p.m. CST. Hundreds of flights already were canceled Friday at the airport. Earlier in the day, a plane slid off an icy taxiway in Kansas City. 395

Thanksgiving Day has come and gone -- but the holiday weather nightmare is not over just yet.As millions of holiday travelers head back home over the weekend, rain and snow will sweep through the Midwest on Saturday then push into the Northeast on Sunday into Monday, CNN meteorologist Haley Brink said.The storm system will cause widespread weather-related hazards through the Thanksgiving weekend as it tracks west to east across the lower 48, the 461