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SAN DIEGO (KGTV) — At least six companies are working on COVID-19 vaccine candidates in San Diego, all within a 1.5-mile radius of where the I-5 and I-805 split.Locally, the farthest along appears to be Inovio Pharmaceuticals, which plans to launch a Phase 2 trial next month, potentially with a simultaneous Phase 3 trial. A Phase 3 trial is the final step in vaccine testing, with thousands of participants.The company is developing the vaccine using a DNA technique that isn’t used in any other vaccines on the market, although some are in the final stages of testing, said Dr. Kate Broderick, who leads Inovio’s vaccine program.To ensure the DNA enters a person’s cells, the company uses a proprietary device about the size of a toothbrush to deliver doses into the skin rather than a needle and syringe. The company announced Tuesday it secured a million grant from the Department of Defense to speed up production of the devices.Just down the street, TriLink Biotechnologies is working with researchers in London on a vaccine candidate that replicates itself in the body. It just started a Phase 1 trial this month.Nearby, Sorrento Therapeutics is working on both a COVID-19 vaccine and a treatment, but it hasn’t advanced yet to human trials. 10News previously featured the company’s efforts, which are based on techniques developed to fight cancer.On the other side of the 805, Arcturus Therapeutics is working with Duke University on a vaccine based on RNA, which acts as a messenger for DNA. There are no vaccines approved for humans that use this RNA approach. Trials are expected to begin in August, according to a tracker by the Milken Institute.UC San Diego is developing a vaccine using plant virus nanotechnology, leveraging an approach that’s used in vaccines against Hepatitis B and shingles. The university is also taking part in research on a COVID treatment.A spokeswoman for San Francisco-based Vir Biotechnology says the company is using its San Diego satellite office to help crunch data for the work on its vaccine, which is a collaboration with GlaxoSmithKline (GSK).GSK, Janssen, and Pfizer each have vaccine candidates of their own and offices near the 5-805 split, but 10News was not able to immediately confirm if any of those companies were conducting COVID research locally. 2318

SAN DIEGO (KGTV) - Californians associate “The Big One” with a devastating earthquake, but U.S. Geological Survey experts say a potentially larger threat could hit the state in the form of an “ARkStorm.”SPECIAL REPORT: Complete coverage of California's winter stormsExperts from every scientific field related to a potentially disastrous weather event gathered in 2010 to create the ARkStorm Scenario report for the USGS, imagining aspects of flooding of biblical proportions reaching the Western United States.“These storms do pose a real risk to California, in some ways far greater than that of earthquakes,” experts said in the study.The ARkStorm Scenario report reads like a Hollywood post-apocalyptic film script. Weeks of rain and snow are followed by catastrophic floods, landslides, and property and infrastructure damage which would cripple California’s economy.While the name “ARk” brings to mind a lifeboat scenario, ARkStorm project manager Dale Cox and chief scientist Lucile Jones coined the abbreviation to represent “atmospheric river.” A common term for meteorologists, these rivers in the sky work like highways for water vapor which comes to a screeching halt when it reaches land.A typical atmospheric river is the Pineapple Express, which pushes moisture from the tropics to the West Coast. It was a Pineapple Express that reached San Diego on Valentine’s Day, bringing warmer rain and lower snow levels, according to National Weather Service meteorologist Alexander Tardy.RELATED: Mega storm could cause billions in damage to California, report showsModels in the ARkStorm report show multiple areas of submergence in central San Diego. Mission Beach, which routinely sees flooding during heavy rain, is underwater in the ARkStorm scenario. Fiesta Island, ordinarily dry, disappears under Mission Bay.West-facing beaches, including those near Highway 1 in North San Diego County, are covered in water. Imperial Beach fares no better in its known run-off spots.“You have this outflow then you have the storm pushing in; it dams up,” says Cox of the coastal flooding impact.RELATED: How to check if your neighborhood is at risk of floodingTiming is critical in the creation of an ARkStorm. The same amount of precipitation predicted in the ARkStorm Scenario fell in 2017, says Cox. What made the difference in the impact, he says, is that the rain fell in 80 days instead of the 23 days imagined in the report.The West Coast will get notice, but not much, Tardy says. The most reliable models could give Californians a three-week warning for heavy rain.“We’re going to see it coming, but not where we can build a new levee,” Tardy said.RELATED: How San Diego's flooding compares to FEMA's historical hazard mapThe timing of the next ARkStorm is uncertain.“It could be next year, or it could be 120 years from now,” said Tardy.San Diego has seen significant rainfall in the 2018-2019 season, but few storms in recent years can compare with the potential disaster envisioned in ARkStorm.RELATED: Photos: Flooding catches San Diego by surprise“How do we help people understand it can get bigger than what they remember,” Jones said. “We prepare for the ones that we remember.”To create the report, experts accessed information from the records of Spanish ships off the coast of San Francisco in the 1600s. Other data were collected from tree rings, and newspaper reports from Sacramento in 1861 and 1862, the years an epic storm submerged California’s Central Valley past the level of telephone poles.As severe as it may seem, the ARkStorm Scenario is not the worst case scenario, said Jones.“If it has happened, it can happen again. And it probably will happen again.” 3695

SAN DIEGO (KGTV) - Another child has been diagnosed with E. Coli linked to animals at the San Diego County Fair, San Diego Health and Human Services officials reported Tuesday. The latest case involves a 6-year-old boy who visited animals at the fair on June 22, officials said. The boy began showing symptoms of Shiga-toxin-producing E. Coli (STEC) four days later. He was not hospitalized. 2-year-old Jedediah Cabezuela died of the illness and three other children were sickened by E. Coli, fair organizers said Friday.RELATED: Family mourns toddler dead after E. Coli exposure at San Diego County FairHealth officials confirmed Tuesday a previously reported case involving a 9-year-old child who was not hospitalized was due to E. Coli. “As we continue our investigation, more cases are likely to be reported,” said Wilma J. Wooten, M.D., M.P.H, County public health officer. “This is typical of any public health investigation. Since we asked doctors to be on the lookout for STEC, they are more likely to test patients exhibiting symptoms.” E. Coli can incubate over a period of 10 days. Fair officials closed the animal exhibits to the public on June 28. RELATED: Two-year-old boy dead, three sickened due to E. Coli linked to San Diego County FairSymptoms of E. Coli include bloody or watery diarrhea, vomiting, and severe abdominal cramps. The infection is contracted through a naturally-occurring bacteria in animals. 1435

SAN DIEGO (KGTV) — Construction has started on Mission Valley's first public elementary school.The new preschool through 5th-grade campus at the corner of Via Alta and Civita Boulevard will serve residents living in the Civita residential development. Families living in the Mission Valley and Fashion Valley neighborhoods will also make use of the new school.The campus will feature classrooms with roll-up doors that open to the outside for 1st- through 5th-grade students; dedicated play areas for preschool, kindergarten, and 1st- through 5th-grade students; "makerspaces" for students; and an indoor-outdoor multipurpose facility.San Deigo Unified School District provided a virtual walkthrough of the campus here."With more significant growth planned in the area, we must prepare for the influx of new families and students," said Dr. John Lee Evans, Board of Education President. "This community deserves a quality neighborhood school."The campus will enroll up to 500 students and construction is expected to finish in spring 2022.The new school is funded through 2012's voter-approved Proposition Z bond measure, state schools facilities funding, and developer fees, according to San Diego Unified School District. 1231

SAN DIEGO (KGTV) - Applications are now being accepted for the CONNECT ALL @ the Jacobs Center Business Accelerator Program (CAJC).CAJC is the region's first low-to-moderate income and diversity-focused business accelerator program.The first CAJC group of 13 local startups included businesses in retail, technology, food, and health and beauty. The founders come from various ethnic backgrounds, including African-American, Asian, Caucasian, Hispanic, and Pacific Islander.Entrepreneurs receive six months of free workspace, mentorship, and workshops - learning skills like how to access capital. Kelly Twichel is one of 13 entrepreneurs in CONNECT ALL's first cohort. Her woman-owned company Access Trax was born in a college classroom. "It's important because you want to level the playing field. Anybody has and can come up with a great idea."Twichel and the rest of the first CONNECT ALL cohort will finish their program in October. "Not having to give up equity in my company meant a lot to me because I wanted to grow this as organically as possible and really maintain control. We are a woman-owned small business, and I wanted to do everything I could to continue to foster that."She's now in the running for the Amber Grant for Women Entrepreneurs contest; if awarded, Twichel's company would receive ,000. Community members can vote for her company now through December. The goal of CONNECT ALL is to grow startups into thriving businesses which go on to hire local and strengthen the City of San Diego's economy. The program is funded through Community Development Block Grant program funds provided by the U.S. Department of Housing and Urban Development to the City of San Diego, and private funding from partners, such as MUFG Union Bank N.A. and bkm OfficeWorks.Click here to apply. 1810