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Trade with Japan is a major flash point for Trump, who is on a lengthy tour of Asia. The U.S. runs a billion trade deficit with Japan, and Trump has made reducing that figure a priority. 190

This is really a law for people who are very sick, who have exhausted all treatment options and who cannot enroll in a clinical trial, said Starlee Coleman, senior policy adviser at the Goldwater Institute, a conservative public policy think tank based in Phoenix that supports right-to-try legislation."For people living in a state where right-to-try is already on the books, they already have the ability today to work with their doctors directly to approach a drug company with a drug in clinical trials and ask for the option to try that drug outside of the clinical trial," she said. "For people living in the 12 states without a right-to-try law, today they don't have this option, but if the federal law passes, they will have the option."Some opponents argue that the bill won't change much but could have a detrimental effect on how the FDA safeguards the health of the public.Dr. Steven Joffe, professor in medical ethics and health policy at the University of Pennsylvania's Perelman School of Medicine, co-authored a perspective paper about such concerns, published in the New England Journal of Medicine last month.The paper notes that the FDA already has expanded-access policies, sometimes called compassionate use, to give terminally ill patients without other options access to investigational medical products outside of clinical trials.About 99% of submitted applications for expanded access to almost 9,000 investigational drugs were allowed to proceed over a 10-year period between January 2005 and December 2014, according to a study by FDA researchers, published in the journal Therapeutic Innovation & Regulatory Science in 2016."Emergency requests for individual patients are usually granted immediately over the phone and non-emergency requests are generally processed within a few days," FDA Commissioner Dr. Scott Gottlieb said in a statement last year. 1885

There's a lot of things going on in their lives, said Cox spokesperson Ceanne Guerra. "Having computers and internet has made it easier for them and gives them a better feeling. They're more engaged and attentive to their education." 233

There was a lot built into it at the beginning of the year -- none of that's materialized, says Kathy Jones, chief fixed income strategist at Charles Schwab. "No infrastructure spending, no tax cuts...it really has flipped the script from where we were at the beginning of the year until now." 293

Trabuco and Holy Jim canyons were also under mandatory evacuation orders, as well as the Blue Jay and El Cariso campgrounds. All campgrounds in the Trabuco Ranger District were closed and forest road closures were in effect for Trabuco Creek, Maple Springs, North Main Divide, Bedford and Indian Truck Trail.Riverside County created a website for residents to look up their evacuation status. 392