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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) - It could take more than three weeks for out-of-work Californians to get unemployment insurance payments.The California Employment Development Department (EDD) tells 10News, during normal circumstances, an Unemployment Insurance (UI) claim takes approximately 21 days from filing to payment.Right now, the circumstances in California are anything but normal.According to a report from the state's Legislative Analyst's Office, "Given the extraordinary number of applications received recently, as well as the expectation that claims will continue to increase over the coming weeks, the Legislature should anticipate that first benefit payments will take much longer than 21 days."The report states similar delays occurred in the Great Recession. EDD tells 10News they are currently experiencing a large increase in claims filed in their programs and have staff working overtime to keep up with the demand."Given the unprecedented increase in UI claims due to COVID-19, we have taken several steps — working around the clock, including Saturdays and Sundays, and redirecting hundreds of staff to process UI claims — to ensure every Californian gets benefits as timely as possible. We do not expect any significant delays at this time. Should the situation change, and delays arise, we will notify the Governor's office, stakeholders, and the public as soon as possible," an EDD spokesperson told 10News."We're seeing impacts higher than what we saw at the Great Recession," said Andrew Picard with the San Diego Workforce Partnership.This week the organization put out a report on potential impacts of COVID-19 on employment in San Diego County.The report stated, "In the first three days of partial closures (March 16-18), Californians submitted 190,000 unemployment insurance claims — more than quadruple the weekly average — and the March 19 statewide order to shelter in place will bring more layoffs."Between March 16 to 22, the Workforce Partnership received notices or phone calls from 52 employers that are considering or have executed layoffs or work-hour reductions for a total of 3,865 impacted workers. EDD said they encourage Californians to apply if they think they may qualify for benefits. Officials suggest using online services for faster processing, if possible. 2306

SAN DIEGO (KGTV) — Leaders from Mexico and San Diego led a conference on the effort to end human trafficking Tuesday at Liberty Station. Carlos Gonzalez Gutierrez, who recently took over as Mexico's Consul General in San Diego, was the first speaker, followed by San Diego District Attorney Summer Stephan.An estimate by the United Nations reveals that millions of people are living in modern day slavery worldwide. In San Diego, the most common form of human trafficking is for sexual exploitation. The District Attorney's office told 10News that between 3,000 and 7,000 women are sex trafficked through the county each year, with the average age of the victim's being just 16.RELATED: Two teens arrested in San Diego for possible sex trafficking of 12-year-old girl"We have to watch the borders, but we also have to watch in the privacy of the bedrooms of our kids," Stephan said during an interview with 10News.The forum came just a few days after 18 Camp Pendleton Marines and one Navy sailor were arrested, accused of taking part in human trafficking and drug smuggling from Mexico. At least one marine allegedly accepted a ,000 payment to transport undocumented immigrants after they made their way into the United States."It isn't surprising that they would use persons that would appear trustworthy like our military in order to transport either humans or drugs," Stephan said. 1395

SAN DIEGO (KGTV) -- Just days before masses of people are expected to descend on Del Mar for the San Diego County Fair, a busy road has reopened following a bluff collapse. City crews completed a retaining wall and reopened Jimmy Durante Boulevard Wednesday afternoon. The road wasn't originally expected to reopen until June 4, several days after the fair opens on May 31. RELATED: What to know for the San Diego County FairThe northbound lanes of Jimmy Durante Boulevard closed in late April after part of a bluff collapsed. The cost of cleanup and stabilizing the cliff is expected to cost million. At a meeting in May, the city council voted to declare a local emergency, allowing the city to qualify for federal emergency funds. 745

SAN DIEGO (KGTV) — Jayce Tingler doesn't plan to be a homebody in the San Diego Padres clubhouse."I want to be shagging in the outfield ... If you're out being active, more organic natural moments will arrive," Tingler told reporters, saying that he doesn't plan to sit in his office often.The Padres introduced the former Texas Rangers coach to the media at Petco Park Thursday. In front of a backdrop of brown and gold, general manager A.J. Preller spoke on Tingler's experience and confidence in him managing the team starting in 2020. Notably, Preller said he was looking for someone players would "run though a wall for" in his search.RELATED: San Diego Padres to unveil new 2020 uniforms in NovemberBefore Tingler arrived in San Diego to don number 32, he worked with the Rangers has a field coordinator and interim bench coach. Preller hailed Tingler's experience in player development for the organization, and bilingual and communication skills. The duo worked together while Preller was a scout and assistant general manager in Texas. Preller said Thursday that Tingler had showed him that he's "comfortable being uncomfortable" from his success as a young manager in the Dominican Republic.But the big question for many outside of Preller's is Tingler's experience. He becomes the Padres 21st manager in franchise history and the team's sixth-straight skipper without prior MLB managerial experience."Look, I'm going to make mistakes. My guess is at some point the players are going to make mistakes. So we have some common ground," Tingler said. "I hope to learn quick. I hope to have people around from various areas of expertise."Part of the expected change between 2019 to 2020 will include other coaching positions. Tingler says he's looking to surround himself with a staff that pushes players."We're in that process. We're meeting with people. The bottom line, can you build relationships and can you impact players, can you push them and make them better," Tingler said.Tingler walks into a club that has under delivered for the last decade. Last season marked the Padres' ninth-straight losing season. Former manager Andy Green didn't fair better, posting a .428 win percentage during his four seasons with the team.The last time the team finished above .500 was in 2010, under then-manager Bud Black.To that, Tingler says he's confident in the current squad of players and looks forward to his new staff forming those all important relationships to impact young players — hopefully producing a winning season."We've got a lot of players with huge upside ... I think they shared that kind of undying passion to win here in San Diego," Tingler said. 2676