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SAN DIEGO (KGTV) - California health officials announced Friday the steepest climb in positive coronavirus cases in history."When I'm worried I'll tell you so you can worry with me and we're there," California Health and Human Services Secretary Dr. Mark Ghaly said. He's worried hospitals could be overwhelmed if we don't stop the rapid spread of the virus."This rapid rate of rise could be even higher if we don't act soon," Dr. Erica Pan, state epidemiologist and deputy director of the California Department of Public Health Center for Infectious Diseases, said.Pan added that we could have a higher spike than we saw over the summer.Many are taking their words to heart and stocked up to stay home. San Diegans saw empty shelves and product limits this week across the county, but officials urge consumers not to worry."We didn't put limits on early enough. There's plenty of product in the supply chain and we just thought it would be better to be proactive because when people only buy what they need there's plenty of supply in the supply chain," said. Kroger CEO Rodney McMullen, asking customers to only buy what they need.When it comes to another lockdown, Director of the National Institute of Health Dr. Anthony Fauci says it's unnecessary. "Public health measures, not lockdown of the country, but public health measures that are simple and easy to understand. The universal wearing of masks. The physical distancing. The avoiding congregating and crowded places. Outdoors is better than indoors, washing hands. It sounds simple in the context of this ominous outbreak but it can turn it around and that's what we need to do," Fauci said.Dr. Ghaly said that doesn't mean more restrictions are off the table. "If additional changes to the purple tier are required we will be working with our local partners to determine what's there ... We are not looking today at a state-wide stay-at-home order," said Ghaly. 1931

SAN DIEGO (KGTV) — As temperatures hit highs across the county's eastern portion, officials are taking annual precautions to close several popular hiking areas.Six county parks will be closed throughout August, including El Capitan Preserve near Lakeside, Hellhole Canyon Preserve in Valley Center, Mt. Gower Preserve near Ramona, Wilderness Gardens in Pala, Agua Caliente Regional Park in Anza Borrego, and Vallecito County Park near Julian.Agua Caliente Regional Park and Vallecito County Park are closed all summer until Labor Day weekend.The closure also gives park staff the chance to perform maintenance and other upgrades and restoration projects.For hiking and park areas that remain open all summer, county Parks and Recreation officials encourage visitors to always hike with others, leave pets at home on difficult hikes, take plenty of water and food, and dress appropriately for the activity. 913

SAN DIEGO (KGTV) - Cleanup started this week on a canyon that caught on fire March 27. The fire started in the canyon near Highway 163 below the Vermont Street pedestrian bridge that connects Hillcrest and University Heights. RELATED:  258

SAN DIEGO (KGTV) — At least six companies are working on COVID-19 vaccine candidates in San Diego, all within a 1.5-mile radius of where the I-5 and I-805 split.Locally, the farthest along appears to be Inovio Pharmaceuticals, which plans to launch a Phase 2 trial next month, potentially with a simultaneous Phase 3 trial. A Phase 3 trial is the final step in vaccine testing, with thousands of participants.The company is developing the vaccine using a DNA technique that isn’t used in any other vaccines on the market, although some are in the final stages of testing, said Dr. Kate Broderick, who leads Inovio’s vaccine program.To ensure the DNA enters a person’s cells, the company uses a proprietary device about the size of a toothbrush to deliver doses into the skin rather than a needle and syringe. The company announced Tuesday it secured a million grant from the Department of Defense to speed up production of the devices.Just down the street, TriLink Biotechnologies is working with researchers in London on a vaccine candidate that replicates itself in the body. It just started a Phase 1 trial this month.Nearby, Sorrento Therapeutics is working on both a COVID-19 vaccine and a treatment, but it hasn’t advanced yet to human trials. 10News previously featured the company’s efforts, which are based on techniques developed to fight cancer.On the other side of the 805, Arcturus Therapeutics is working with Duke University on a vaccine based on RNA, which acts as a messenger for DNA. There are no vaccines approved for humans that use this RNA approach. Trials are expected to begin in August, according to a tracker by the Milken Institute.UC San Diego is developing a vaccine using plant virus nanotechnology, leveraging an approach that’s used in vaccines against Hepatitis B and shingles. The university is also taking part in research on a COVID treatment.A spokeswoman for San Francisco-based Vir Biotechnology says the company is using its San Diego satellite office to help crunch data for the work on its vaccine, which is a collaboration with GlaxoSmithKline (GSK).GSK, Janssen, and Pfizer each have vaccine candidates of their own and offices near the 5-805 split, but 10News was not able to immediately confirm if any of those companies were conducting COVID research locally. 2318

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526