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Immunotherapy has gained ground against a stubborn opponent: ovarian cancer. A personalized cancer vaccine is safe and may lengthen the lives of ovarian cancer patients, a small clinical trial found.The research, published Wednesday in the journal Science Translational Medicine, showed "significantly higher" overall survival at two years among patients who received the vaccine, compared with patients who did not.Ovarian cancer is a "silent killer" because often it goes unnoticed until it is diagnosed at a late stage. Treated with surgery followed by chemotherapy, most patients -- 85% -- relapse and ultimately develop resistance to the chemo. At this point, they run out of treatment options.Still, scientists are hopeful based on the fact that a subset of patients shows an immune response to their cancer. Generally, these patients have better survival rates than those whose immune systems don't react in the same way.A vaccine, then, might be able to trigger and boost the immune system and increase the survival rates of patients, said Dr. Lana Kandalaft, senior author of the new study and an adjunct assistant professor at the University of Pennsylvania Perelman School of Medicine.  1210

I’m happy to report that Jill and I have tested negative for COVID. Thank you to everyone for your messages of concern. I hope this serves as a reminder: wear a mask, keep social distance, and wash your hands.— Joe Biden (@JoeBiden) October 2, 2020 256

If flying is one of your fears, you're not alone. One class has been helping people overcome the fear for decades, by debunking some of the concerns keeping you on the ground."The plane just dropped suddenly," one woman remembers."We actually went up in an airplane and found out afterwards we had gone up in a hurricane," another woman recalls."What really scares me is somebody blowing something up on purpose," one traveler says."I actually thought I was going to die, says another traveler."It's led to some odd routines. "I have to like touch all four sides of the door on the way in and you know with the seats," says one passenger. "And count to 100 during take off."It has almost led do some missed opportunities."I thought ok I'll just never fly again I'm old I don't care," one woman says. "But my daughter is going to college and I want to go with her."That's why these people have decided to not only share but face their fears in this Fear of Flying Clinic. Students learn it's not the fear that's the problem but the way they think about it. And once that changes so does the fear."It's not easy to do because you do have a whole set up of automatic beliefs that are causing you trouble," says one of the class instructors.That's why debunking students' biggest fears is so important."I have some very disappointing news for you all about turbulence," says commercial pilot Captain Mark Connell. "We don't care. It doesn't make much difference to us."As scary as it might feel, Captain Connell compares a plane hitting turbulence to a car hitting a pothole. He covers everything from turbulence and weather, to pilot training and preparedness."There's something helpful about that to think to yourself well he flies planes all the time and he's not scared so I probably shouldn't be scared either," says Mimi Kravetz.Kravetz has been scared of flying since she was 10."When there's turbulence on an airplane, my heart starts beating quicker. I feel really panicky. I can't focus. I can't sleep and I wanted to get out of that feeling," Kravetz says.Now she's ready to face her fear. "It'll be interesting on Monday to try and go in to see if I can replace my current set of thoughts with a set of new ones," Kravetz says.And get into the air with as much ease as the plane she's riding in.      2351

If I am sent a Stand Alone Bill for Stimulus Checks (,200), they will go out to our great people IMMEDIATELY. I am ready to sign right now. Are you listening Nancy? @MarkMeadows @senatemajldr @kevinomccarthy @SpeakerPelosi @SenSchumer— Donald J. Trump (@realDonaldTrump) October 7, 2020 296

House Republicans are announcing they're leaving office at a significantly faster rate than any other recent Congresses, suggesting Democrats could pick up seats in the 2018 midterm elections. On Wednesday, CNN reported House speaker, Wisconsin Republican Paul Ryan, would be next.Already, at least 42 House Republicans have announced they are retiring, running for another office or resigning outright, including Ryan. They're leaving from all over the map, from southern New Jersey to southern New Mexico.Democrats need to pick up 24 House seats to retake the majority from Republicans, who've had control of the House since 2011.Republican leadership has acknowledged it has a problem."We've got to find better ways to empower people where they feel like this is worth their time," Rep. Pete Sessions of Texas, a former two-term National Republican Congressional Committee chair who met with several members to discuss retirements, told the National Journal in September.But the retirements kept coming.While midterm elections are historically tough for the party of the President in power, it's too early to tell how things will unfold this year. But seats are opening up all over. A few seats will be filled by special elections before next November. But most won't.The locations of some of these seats were pivotal during the push for health care reform and tax reform in 2017. Reps. Frank LoBiondo of New Jersey and Charlie Dent of Pennsylvania were courted during the health care debates for their votes. Both have high numbers of Medicaid enrollees in their districts. Property taxes are high in New Jersey, and LoBiondo objected to the repeal of the state and local tax deduction during the tax reform debates.Some states are seeing higher numbers of open seats. And not all of the vacancies are coming from Republicans. Several vacancies opened in Texas, including the blue 16th Congressional District, won by Democrat Beto O'Rourke in 2016. He announced that he plans to run for the Senate in 2018.Seats have opened as a result of sexual harassment inquiries or accusations. Among Democrats, Reps. Ruben Kihuen of Nevada and John Conyers of Michigan announced they would leave Congress following pressure to resign, though Kihuen plans to finish his term. On the Republican side, Rep. Trent Franks of Arizona resigned and Rep. Blake Farenthold of Texas announced he will resign, both following sexual harassment accusations.The campaign committees on both sides of the political aisle are eyeing the 23 Republicans defending districts that Hillary Clinton won in 2016 and the 12 seats held by Democrats in districts that President Donald Trump won. These are seen as vulnerable seats to flip.But many of the Republican retirements are occurring in districts where Trump narrowly carried the vote, like New Jersey's 2nd or Michigan's 11th. Members from these districts could have faced tough re-elections this year, when Democrats are expected to be strong performers, potentially regaining control of the House.Republicans who say they will run for other offices are more likely to come from districts where Trump performed well. These members vote in alignment with the President at a high rate. They may count on continued support from his base to propel them into higher office.With few exceptions, the Republicans and Democrats who are retiring largely vote along party lines. They also have levels of support for the President's agenda similar to those of their respective parties.Past research has found the emergence of "strategic retirement" by politicians when they think re-election is less likely. The recent results in Virginia and subsequent Republican departures suggest this phenomenon may be in effect.Here is the full list of representatives so far who have announced that they plan to leave office, broken down by whether they said they will resign, retire or run for another office. Some members resigned before their terms ended.While the number of Democrats and Republicans planning to run for another office is close in number, the number of House Republican retirements dwarfs those announced by Democrats. Members from either party planning to run for another office tend to run for Senate seats or governorships.Scandal has also led to some resignations. Rep. Tim Murphy of Pennsylvania announced he would retire after the anti-abortion GOP congressman admitted that he had had an affair and had urged an abortion.  4465