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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A major crackdown could be coming to stop those annoying robocalls. New research from YouMail--a company that developed robocall blocking software--shows each person on the country receives about 150 robocalls a year.Alex Quilici, CEO of YouMail, says these terribly annoying calls keep increasing for two reasons. "One is there are more and more scam calls. The second thing that's driving the increase is people aren't answering the phone anymore," Quilici says.Because people don’t answer their phones, it makes the robocallers place more calls, he says.It’s a problem both Democrats and Republicans can agree on.  Senators John Thune, R-South Dakota, and Ed Markey, D-Massachusetts, have proposed bipartisan legislation to increase the penalties for robocalls to ,000. They are also proposing to extend the time after a crime in which prosecutors must bring their case from one years to three years.Commercial robocalls are illegal, but the Federal Trade Commission, which is tasked with investigating and charging those who have violated the anti-Robocall federal law, has a hard time prosecuting offenders within the current one-year time limit. “If you look at the current enforcement efforts, there's been a 0 million fine and million fine that's covered people who've made 100 million robocalls or a couple hundred million robocalls. That's a drop in the bucket of the nearly 50 billion we're going to have this year,” Quilici. “It's going to take a lot more than just enforcement and some better regulation to solve the problem."Until legislation to crack down on people who make robocalls passes, Quilici suggests:  1674

A Euclid, Ohio man has been indicted on six counts of rape and numerous other charges after police believe he broke into a woman’s apartment and brutally beat and sexually assaulted her over the course of five hours.The victim’s daughter said her mother underwent a second surgery on Tuesday as doctors worked on reconstructing the broken bones in the woman’s face. The emotional wounds, however, will take years to heal — if at all, she said. Archie Leak, 52, has been indicted on six counts of rape, gross sexual imposition, aggravated burglary, aggravated robbery, assault, two counts of kidnapping, petty theft and tampering with evidence in connection with the March 29th incident.The victim’s family said Leak used a crowbar to gain entry into the woman’s apartment on E. 200th Street. Over the next several hours, Leak allegedly raped and beat the woman. He also reportedly stole some of the victim’s cash and food before leaving around 7:30 that morning, the victim’s family said.The victim then lay in the apartment for three more hours until a neighbor heard her cries for help.“She’s traumatized. Her life is not going to be the same, not at all,” the victim’s daughter said.The victim’s daughter did not want to be identified in an effort to protect her mother’s identity.The reported assault left the victim with several broken bones in her face, which lead to extensive swelling. Doctors spent several hours on Tuesday working to repair the damage. The victim’s daughter said doctors have given her mother a 25 percent chance of regaining her vision.“You can’t even open a can of pop around my mom now. She thinks it’s a gunshot. You can’t touch my mom’s arm. My mom is not the same,” the victim’s daughter said. “She was always very loving and wanting to hug, and now you can’t even touch her.”The victim’s daughter said Euclid police detectives used forensic evidence collected at the scene to quickly identify Leak as a suspect. Leak has an extensive criminal history dating back to 1989, including convictions for burglary. The victim’s daughter lauded the efforts of Euclid police, especially over the Easter holiday weekend.“We were worried about [delays] because it was a holiday. [Police said], ‘no, with this case we’re going through,’” the victim’s daughter said. “I was so thankful that Euclid PD was able to get him.”The victim’s daughter said her mother had only seen Leak once, but had never spoken to him. Her mother was always cautious and had lived at her apartment for more than a decade without any issues. Additionally, the daughter said she spoke to her mother the night before to check in on her.“For this to happen to somebody like her, it makes you think there’s no good people anymore,” the victim’s daughter said. “It doesn’t matter if you’re a good person because bad things, horrible things, will happen to you no matter what.”The victim has a long road to recovery and already faces mounting medical bills. The victim’s family has started a GoFundMe page in order to help cover some of the expected medical debt. As of Tuesday afternoon, more than 00 had been raised. 3161

A Black man who was stopped by sheriff’s deputies while jogging in his neighborhood, then later allowed to leave, is partnering with the department to use his experience for training.In late August, Joseph Griffin was jogging when deputies from Volusia County detained him, telling him he “matched the description” of a suspect they were chasing.“Hey buddy, you’re not in trouble or anything,” the deputy starts on the video, telling Griffin he matches the description of a burglary suspect being sought nearby. “Literally they said white tank top and black shorts, and had a beard. I’m not saying it’s you,” the deputy said, telling Griffin he wanted to check in with other deputies at the scene.In the video, you can hear the deputies radio fellow investigators and double check the description. The deputy later tells Griffin he is being told to detain him. The deputy offers to hold Griffin’s phone to continue recording the incident while he is handcuffed.Griffin remains handcuffed for several minutes while deputies wait for confirmation if he is the suspect or not. Griffin stays calm and talks to the deputies during this time.“Seven cop cars, with everything going on, it’s just a little bit scary,” Griffin says. The deputies agree, but say “see it through our eyes,” since he matches the description. “Do you think we want to be out here killing people?”Eventually, Griffin is let go and it is determined he was not the suspect deputies were looking for. The suspect was later arrested. Griffin is seen on camera thanking the deputies, “Officer Estrada, who said from the beginning he wasn’t going to let anything happen to me.” 1648

A limousine company and its owner are under scrutiny after a stretch limousine crashed in upstate New York killing 20 people.For unknown reasons, the 2001 Ford Excursion, operated by Prestige Limousine Chauffer Service, plowed through a stop sign and crashed into a parked SUV in Schoharie, New York, last Saturday. Seventeen passengers, who rented the limo for a 30th birthday party at a brewery, and two pedestrians were killed. The limo driver also died. The company's owner, Shahed Hussain, is currently in Pakistan, New York State Police said.Here is what we know about the limo company and its owner:  620