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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

BEIJING, Jan. 23 (Xinhua) -- An online survey has revealed that Chinese people have a mixed opinion on Sunday's Spring Festival TV gala, the 30th of its kind since 1983, albeit many of them agree that there were innovations and improvements in it.As of 10:00 p.m. Monday, about 48 percent of some 71,000 respondents in the poll held by sina.com.cn, one of China's major portal websites, said they think the gala fall short of their expectations.Another 23 percent of them said they think the gala was just fine, and only 10 percent said it was splendid.The gala, an annual grand celebration broadcast by the China Central Television on the eve of the traditional Spring Festival, China's lunar New Year, is the most-watched TV event in the country."I can see the efforts of the gala staff, but it is still not good enough," said netizen "roam the life" at the Sina weibo, a popular Twitter-like microblogging website.At the Sina weibo website, the topic "grumble at the 2012 Spring Festival TV gala" has outnumbered others with over 64 million comments and become the hottest topic of Monday.Nonetheless, many people acknowledge the innovations and improvements in the gala.The gala made some attempts to take a more public-friendly approach by inviting some "grassroots" performers, such as farmer-singer Zhu Zhiwen, as well as cutting all commercials during the broadcast.A dance performance depicting a romance of peacocks and starring Yang Liping, a well-known dancer in China, is the most-followed topic at the gala's official weibo account, drawing over 3,500 comments.The audience was also impressed by a piano duet played by Li Yundi, first prize winner of the the 14th Frederic Chopin international piano competition, and Leehom Wang, a Chinese-American pop singer-songwriter.Moreover, about 59 percent of the online poll respondents said the stage design was quite cool."There are really many improvements in the gala, but it is absolutely difficult to please everyone," wrote weibo user "Wawamiaowaiwai."Unlike their elder generation, the young generation in China has more diversified options for entertainment, and it is of great challenge to attract them at the Spring Festival celebration, said Xia Xueluan, a professor of sociology with Peking University.

NEW YORK, Dec. 1 (Xinhua) -- New York City Mayor Michael Bloomberg announced on Thursday a new recommendation that doctors offer every person with an HIV diagnosis antiretroviral treatment to help them live longer and prevent transmission.This marks a change from the current practice that treatment only be offered to those who show signs of damage to their immune systems, said the mayor during the annual World AIDS Day commemorative ceremony at Gracie Mansion. "Over the past ten years HIV diagnoses and deaths in New York City have seen a dramatic decline," said Mayor Bloomberg. "Steady progress in our fight against HIV has turned what used to be a death sentence into a disease that can be prevented and, with antiretroviral therapy, managed.The annual death toll from HIV in the city is down by more than a third: 933 deaths in 2009Despite this progress, however, more than 110,000 people in New York City are infected with HIV, more than in any other U.S. city and about 75 percent of all cases in the New York State.Figures from the New York City Health and Hospitals Corporation (HHC) showed that HHC has tested more than one million New Yorkers for HIV since 2005 when the public hospitals and health centers began offering HIV screening as a routine part of medical care for patients aged 13 to 64.

WASHINGTON, Nov. 8 (Xinhua) -- Children with autism have more brain cells and heavier brains compared to typically developing children, according to a study to be published on Wednesday in the Journal of the American Medical Association.The small, preliminary study provides direct evidence for possible prenatal causes of autism.The prefrontal cortex is involved in various higher order functions such as language and communication, social behavior, mood, and attention. Children who have autism tend to show deficits in such functions.Eric Courchesne, of the University of San Diego School of Medicine Autism Center of Excellence, and colleagues conducted direct counts of brain cells in specific regions of the prefrontal cortex in postmortem brains of seven boys who had autism and six typically developing males, ranging in age from 2-16 years. Most participants had died in accidents, but the researchers did not base their selection on causes of death.The researchers found that children with autism had 67 percent more neurons in the prefrontal cortex and heavier brains for their age compared to typically developing children. Since these neurons are produced before birth, the study's findings suggest that faulty prenatal cell birth or maintenance may be involved in the development of autism. Another possible factor that may contribute to the neuronal excess is a reduction in apoptosis, or programmed cell death, which normally occurs during the third trimester and early postnatal life.Though small, this preliminary study examined all relevant postmortem tissue available at the time. The relative scarcity of tissue from very young children may limit future research as well, but efforts to include a larger number of samples are needed to confirm these findings and to identify patterns of age-related changes in autism, the researchers say."Earlier studies of head circumference and early brain overgrowth have pointed us in this direction, but there have been few quantitative neuroanatomical studies due to the lack of postmortem tissue from children with autism," said Thomas Insel, director of the National Institute of Mental Health, in a statement. "These new results, along with an earlier study reporting altered wiring of the prefrontal cortex, focus our attention on this critical area of the brain in autism."

BEIJING, Nov. 4 (Xinhuanet) -- The amount of trans fat and other nutritional information will be marked on the labels of prepackaged food, according to the country's first national standard for food nutrition. The labeling will take effect on Jan 1, 2013. "It will help standardize the nutrition facts labeling by food producers and facilitate consumers' rights to know and choose, while improving public awareness of food nutrition," said Yang Yuexin, a senior nutritionist with the Chinese Center for Disease Control and Prevention (CDC). The new regulation by the Ministry of Health stipulates that food labels have to include the food's nutrition information, including levels of energy, protein, fat, carbohydrate and sodium. Food products without proper labels showing the nutritional information will be banned when the new rule takes effect. The new regulation also stipulates that if any hydrogenated or partially hydrogenated fat is used to produce the food, the level of trans fat will have to be highlighted on the nutrition information label. Trans fat is usually produced during food processing when liquid oils are converted into semi-solid fats that help keep food fresh longer. However, the partially hydrogenated oil contains trans fat that can substantially increase the risk of heart disease. However, Zhang Jian, a researcher with CDC's National Institute for Nutrition and Food Safety, said that compared to Western diets, the Chinese diet contains a far lower level of trans fat and there is no need to over react.