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SAN DIEGO (KGTV) — At least six companies are working on COVID-19 vaccine candidates in San Diego, all within a 1.5-mile radius of where the I-5 and I-805 split.Locally, the farthest along appears to be Inovio Pharmaceuticals, which plans to launch a Phase 2 trial next month, potentially with a simultaneous Phase 3 trial. A Phase 3 trial is the final step in vaccine testing, with thousands of participants.The company is developing the vaccine using a DNA technique that isn’t used in any other vaccines on the market, although some are in the final stages of testing, said Dr. Kate Broderick, who leads Inovio’s vaccine program.To ensure the DNA enters a person’s cells, the company uses a proprietary device about the size of a toothbrush to deliver doses into the skin rather than a needle and syringe. The company announced Tuesday it secured a million grant from the Department of Defense to speed up production of the devices.Just down the street, TriLink Biotechnologies is working with researchers in London on a vaccine candidate that replicates itself in the body. It just started a Phase 1 trial this month.Nearby, Sorrento Therapeutics is working on both a COVID-19 vaccine and a treatment, but it hasn’t advanced yet to human trials. 10News previously featured the company’s efforts, which are based on techniques developed to fight cancer.On the other side of the 805, Arcturus Therapeutics is working with Duke University on a vaccine based on RNA, which acts as a messenger for DNA. There are no vaccines approved for humans that use this RNA approach. Trials are expected to begin in August, according to a tracker by the Milken Institute.UC San Diego is developing a vaccine using plant virus nanotechnology, leveraging an approach that’s used in vaccines against Hepatitis B and shingles. The university is also taking part in research on a COVID treatment.A spokeswoman for San Francisco-based Vir Biotechnology says the company is using its San Diego satellite office to help crunch data for the work on its vaccine, which is a collaboration with GlaxoSmithKline (GSK).GSK, Janssen, and Pfizer each have vaccine candidates of their own and offices near the 5-805 split, but 10News was not able to immediately confirm if any of those companies were conducting COVID research locally. 2318

SAN DIEGO (KGTV) - Boomers! wants to start serving wine and beer at its Kearny Mesa location off I-805.The family entertainment center at 6999 Clairemont Mesa Blvd. asked the city for a zoning change to allow it to serve drinks.Boomers! is known for its child-friendly activities including mini-golf, batting cages, and go-karts.A Boomers! spokeswoman gave 10News a statement about the change: 401

SAN DIEGO (KGTV) - Boomers! wants to start serving wine and beer at its Kearny Mesa location off I-805.The family entertainment center at 6999 Clairemont Mesa Blvd. asked the city for a zoning change to allow it to serve drinks.Boomers! is known for its child-friendly activities including mini-golf, batting cages, and go-karts.A Boomers! spokeswoman gave 10News a statement about the change: 401

SAN DIEGO (KGTV) - Cara Knott's family has written a letter to Gov. Gavin Newsom asking that Craig Peyer remain behind bars.In December 1986, Peyer -- then a California Highway Patrol officer -- pulled over Knott on Interstate 15 in the Rancho Penasquitos area. Peyer beat Knott, strangled her, and threw her body over a bridge.Peyer was eventually convicted of killing the 20-year-old San Diego State student in 1988.Peyer's next parole hearing isn't until 2027, but in their letter to the governor, Knott's family says they've learned inmates are being released from Peyer's prison because of COVID-19.“This is precisely NOT a person who deserves to be released early from prison for humanitarian reasons. Officer Peyer showed NO Mercy when he murdered my sister," Knott's sister wrote in her letter to the governor.ABC 10News reached out to California Department of Corrections and Rehabilitation for clarification. CDCR says, at this time, there are no plans to expedite the release of Craig Peyer."He committed a betrayal of trust that's unmatched in San Diego history at my judgment," said Paul Pfingst, who prosecuted the case. "If we don't have room for him in prison, because of a risk that he might catch a disease that all of us have a risk to catch, I think that would be a grievous mistake." 1312

SAN DIEGO (KGTV) — As San Diegans gear up for the Fourth of July, a new Gallup Poll puts American patriotism at a nearly 20-year low.The poll blames the country's sharply polarized political climate. It found that 45 percent of those polled were "extremely proud" to be American, while 70 percent said they were "proud.""Patriotism isn't something that you can force," said David Povlick, who was visiting downtown San Diego Wednesday. "It's something that people have to feel. I think it's being forced right now, and so that makes people rebel a bit."RELATED: California among least-patriotic states in the nation, according to reportStill, the heart of the city was filled with American flags and people sporting USA apparel the day before the Fourth of July. Mike Ismail, who owns Alamo Flags in SeaPort Village, gives out thousands of free American flags for the holiday each year. Ismail said he has visited many countries around the world, making him even more proud to be an American. Ismail said the holiday is above politics. "We're all united as one, it should be all that way," he said. "Democrat, Republican, all that aside, we're all American, that's what it's all about."Gallup says 22 percent of Democrats said they were extremely proud to be American, while 76 percent of Republicans shared that sentiment. 1332

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