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WASHINGTON, March 4 (Xinhua) -- New data suggest that the epilepsy drug Topamax (topiramate) and its generic versions increase the risk for the birth defects cleft lip and cleft palate in babies born to women who use the medication during pregnancy, the U.S. Food and Drug Administration (FDA) said Friday in a statement.Before prescribing topiramate, approved to treat certain types of seizures in people who have epilepsy, health care professionals should warn patients of childbearing age about the potential hazard to the fetus if a woman becomes pregnant while using the drug, the FDA said.Topiramate also is approved to prevent migraine headaches, but not to relieve the pain of migraines."Health care professionals should carefully consider the benefits and risks of topiramate when prescribing it to women of childbearing age," said Russell Katz, director of the Division of Neurology Products in the FDA's Center for Drug Evaluation and Research. "Alternative medications that have a lower risk of birth defects should be considered."Cleft lip and cleft palate, collectively called oral clefts, are birth defects that occur when parts of the lip or palate do not completely fuse together early in the first trimester of pregnancy, a time when many women do not know they are pregnant.The defects range from a small notch in the lip to a groove that runs into the roof of the mouth and nose, possibly leading to problems with eating, talking, and to ear infections. Surgery often is performed to close the lip and palate and most children do well after treatment.Data from the North American Antiepileptic Drug (AED) Pregnancy Registry indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Infants exposed to topiramate as a single therapy experienced a 1.4 percent prevalence of oral clefts, compared with a prevalence of 0.38 percent - 0.55 percent in infants exposed to other antiepileptic drugs.Infants of mothers who did not have epilepsy and were not being treated with other antiepileptic drugs had a prevalence of 0.07 percent. Similar data from the United Kingdom Epilepsy and Pregnancy Register supported the North American AED Pregnancy Registry data.According to the FDA, before starting topiramate, pregnant women and women of childbearing potential should discuss other treatment options with their health care professional.
LOS ANGELES, May 11 (Xinhua) -- U.S. researchers have found MRSA (methicillin-resistant Staphylococcus aureus) in meats sold at U.S. supermarkets, according to a study published on Wednesday.This is "community-acquired MRSA" that is transmitted by humans carrying the bacteria, researchers at Wayne State University in Detroit reported in the study appearing in the May 11 online edition of the U.S. Centers for Disease Control and Prevention's ( CDC's) journal Emerging Infectious Diseases.For the study, the researchers purchased 289 raw meat samples, including 156 beef, 76 chicken and 57 turkey samples, from 30 grocery stores in Detroit from August 2009 through January 2010.The researchers found that 22.5 percent of the samples were contaminated with S. aureus and six samples tested positive for MRSA.Of the six samples contaminated with MRSA, two were beef, three were chicken and one was turkey, the researchers said.The extent of MRSA contamination in meat varies by the type of meat and where the meat was processed, said lead researcher Yifan Zhang, an assistant professor in the department of nutrition and food science at the university.The germ is apparently being introduced by humans handling the meat, she said.According to another recent study, the strain of MRSA in meat in the United States is not the strain found in animals, Zhang noted."MRSA has always been found in human patients, but we found this in retail meat, so retail meat can be a reservoir of these bugs," said Zhang."When people handle food, they can get the bugs from the meat if the meat is already contaminated," she explained.The risk of becoming infected is especially high if you have open cuts or sores on your hands or skin, Zhang added.MRSA is common in hospitals and nursing homes, where it can cause serious illness and even death.But recently "community-acquired MRSA" has become a problem among some high school and college athletes who share equipment.This type of MRSA appears as a skin infection and is usually less serious, according to CDC.MRSA is killed when the meat is cooked thoroughly, experts say.Other precaution measures include:-- Wear gloves when handling meat, especially when there are wounds on the hands;-- Washing plates or utensils used to prepare food before using them again to eat; and-- Disinfect counters that have come into contact with meats.
BEIJING, Jan. 31 (Xinhua) -- Senior Chinese leader Li Changchun Monday visited performers and producers of China Central Television's Spring Festival gala during their rehearsal.Li, a member of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee, extended new year greetings to the crew.Li Changchun (front R), a member of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee, shakes hands with actors at the rehearsal of the Spring Festival Gala Evening at China Central Television (CCTV) in Beijing, China, Jan. 31, 2011. He hoped an excellent show will be presented on the eve of the Spring Festival, or Lunar New Year, which falls on Feb. 3.The annual Lunar New Year gala celebration started in the 1980s. Since then, it has been the most popular TV event, attracting a major portion of China's 1.3 billion population each year.
BEIJING, Feb. 1 (Xinhua) -- Wu Bangguo, chairman of the Standing Committee of the National People's Congress of China, on Monday sent congratulatory messages to Myanmar's newly-elected upper house speaker U Khin Aung Myint and lower house speaker Thura U Shwe Mann, respectively,on their taking offices.Myanmar's house of nationalities (upper house) session on Monday elected U Khin Aung Myint, Minister of Culture, as speaker of the upper house.Also on Monday, No. 3 Myanmar state leader Thura U Shwe Mann, who is a member of the State Peace and Development Council and previously the Chief of General Staff of the army, the navy and the air force, was elected as speaker of the house of representatives by the house of representatives (lower house).
BEIJING, Jan. 24 (Xinhua) -- Chinese Premier Wen Jiabao called on the public to give suggestions on the government work during his visit to central China's Henan Province on Friday and Saturday.Wen visited urban communities and villages in Henan to hear citizens' voices, to prepare for the Report on the Work of the Government, which he will deliver at the National People's Congress in March.He made his first stop at a renovated shanty-town in the city of Hebi, an industrial city reliant on coal mining.Wen visited the family of Song Helian, a factory worker who has just moved from a 50-square-meter room to a three-bedroom apartment.Chinese Premier Wen Jiabao (R, front), who is also a member of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee, attends a symposium in Hebi, central China's Henan Province, Jan. 21, 2011. Wen Jiabao visited urban communities and villages in Henan on Jan. 21 and 22 to hear citizens' voices, to prepare for the Report on the Work of the Government, which he will deliver at the National People's Congress in March. He told local cadres the renovation of shantytowns has a direct bearing on people's livelihoods and must be carried out successfully.During his meeting with residents of a community, Wen told them, "The job of the government is to serve the people and to secure a better life for the people. You are in the best position to criticize the government's work report and the next five-year plan."The residents and Wen talked about recent price rises, medical insurance and employment for laid-off workers among other things.During a visit to a village, Wen met with villagers and stressed the importance of agricultural technology.Wen also called for greater efforts to improve rural health facilities.