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"Faced with such changes, China's mapping providers should innovate their business models and expand the areas outside of guiding itself," said an analyst from iiMedia who sought anonymity.

"Despite the stormy times and overwhelming difficulties Hong Kong is experiencing, I believe that so long as we accurately adhere to the principle of 'one country, two systems', we will be able to get out of the impasse," Lam said.

"Even though the market space for developing generic drug is fairly attractive, we will continue to focus on developing innovative drugs, because we are inspired by the progress China has been making to give more easy access for the patients to both home-made and imported drugs," said Du.

"Entrepreneurs have taken the government's signals to heart and are avoiding investment that may be subject to unstable trade policy impulses," Paal said.

"Expenses cannot be reduced quickly enough and significantly enough to offset the 40 percent reduction in revenue we have experienced," he said in a statement.