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CAMBRIDGE, Mass. – The U.S. government will pay Moderna Inc. up to .525 billion to secure 100 million doses of the company’s COVID-19 vaccine candidate.The U.S. Department of Health and Human Services (HHS) and Department of Defense (DoD) made the announcement Tuesday.HHS says Moderna will manufacture the vaccine doses while clinical trials are still underway to expedite the traditional development timeline and get vaccines to the public as soon as possible.The Trump administration hopes to deliver the vaccines by the end of the year, so long as the U.S. Food and Drug Administration (FDA) authorizes their use.“In creating a vaccine portfolio for Operation Warp Speed, the Trump Administration is increasing the likelihood that the United States will have at least one safe, effective vaccine by 2021,” said HHS Secretary Alex Azar. “Today’s investment represents the next step in supporting this vaccine candidate all the way from early development by Moderna and the National Institutes of Health, through clinical trials, and now large-scale manufacturing, with the potential to bring hundreds of millions of safe and effective doses to the American people.”HHS says the vaccine doses will be delivered to government-designated locations across the country and the U.S. could acquire up to an additional 400 million doses of the vaccine.If viable, the vaccines would be available to the American people at no cost, according to HHS. Healthcare professionals could charge for the cost of administering the vaccine, though.The vaccine, called mRNA-1273, has been co-developed by Moderna and scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The third phase of the vaccine trial, which began July 27, is the first government-funded Phase 3 clinical trial for a COVID-19 vaccine in the nation, according to HHS.“We appreciate the confidence of the U.S. government in our mRNA vaccine platform and the continued support,” said Stéphane Bancel, Moderna’s Chief Executive Officer. “We are advancing the clinical development of mRNA-1273 with the ongoing Phase 3 study being conducted in collaboration with NIAID and BARDA. In parallel, we are scaling up our manufacturing capability with our strategic partners, Lonza, Catalent and Rovi, to address this global health emergency with a safe and effective vaccine.” 2402
CHICAGO, Ill. – A study published this month suggests that by lessening the amount of virus you take in by putting on a mask, you may also lessen the likelihood of getting severely sick if you contract COVID-19.As the race to a safe and effective coronavirus vaccine heats up, new research about masks is changing the narrative on their importance.Last week, CDC Director Dr. Robert Redfield called face masks the most “powerful public health tool we have.”“I might even go so far as to say that this face mask is more guaranteed to protect me against COVID than when I take a COVID vaccine,” said Dr. Redfield.It was a stark change from CDC messaging early on in the pandemic that face coverings would most likely only protect those around you.“That was because there was a lot of data at that time that you can shed the virus at high rates from your nose and mouth even when you feel well,” said Dr. Monica Gandhi, an infectious disease doctor and professor of medicine at the University of California – San Francisco.She co-authored newly published research in the New England Journal of Medicine that theorizes that not only do masks protect the wearer but they may even reduce the severity of the coronavirus when someone gets infected.“We realized that we should be messaging more strongly masks protect you as the wearer and protects others,” said Dr. Gandhi.It theoretically works much like the early days of vaccines that used small amounts of viruses to illicit an immune response in the body. So, by wearing a mask, you are only exposed to lesser amounts of the virus, if any, potentially building up a sort of immunity.“The more virus you get inside, the sicker you are, the less virus you have, the less sick you are. This is called a dose response and it's true of many infections,” said Dr. Emily Landon, an epidemiologist and infectious disease specialist at University of Chicago Medicine.Gandhi says the theory has already been studied and proven in animals.“There was a hamster study that looked at the COVID-19 virus and the more that the hamsters were given, the more sick they got,” she said.Dr. Gandhi says it could also explain the why according to the CDC, 40% of coronavirus patients are asymptomatic.“Countries that mask well have lower rates of severe illness than countries that don't mask well. So, putting it all together, this is our hypothesis.”And while the research is still theoretical, if it bears out, experts say universal mask-wearing could drive up the proportion of people who get less sick from the virus if they do contract it. 2579

CARLSBAD, Calif. (KGTV) -- Carlsbad Police announced Monday that a suspect has been arrested in the murder of Lisa Thorborg, the woman stabbed to death on a North County trail.According to police, Thorborg was found fatally stabbed on the Hosp Grove Trail in late November.The body was found by a passerby who called police.RELATED STORIESCarlsbad neighbors honor murdered woman by finishing her hikeWoman stabbed to death on Carlsbad trail identifiedCarlsbad police: Woman found dead on hiking trail was stabbed to deathAccording to police, a 17-year-old male who lives in Carlsbad was arrested. The name hasn’t been released at this time.“We understand that the community has been on edge since that tragic day in November when Lisa was found on Hosp Grove Trail,” stated Investigations Lieutenant Jason Jackowski. “Our unwavering mission has been to find the suspect for Lisa, her family and the community of Carlsbad.” 930
Buried at the core of "Mulan" is the concept of deception. Deceiving others for the perceived greater good, deceiving an overzealous enemy and even deceiving one's self at a steep price.All of them are at play in the long-awaited, oft-disappointing live-action remake.There are some things going for the oft-dull film.Director Niki Caro, who proved adept at inspirational tales with "Whale Rider," "North Country" and "McFarland, USA," has a pulse on the heart of the feminist fable, about a woman who masquerades as a man to protect her family and homeland. The visuals are dynamic, and the casting is note-perfect.Martial arts legends Jet Li, Donnie Yen and Gong Li play significant roles, and the cinematography and choreography often recalls exaggerated, Ang Lee-style theatrics.The core of the film -- that Mulan could convincingly trick her military comrades into thinking she's a man -- falls flat. While Liu Yifei thrives with the athletic ability and emotion needed in the lead role, the makeup department did her no favors. She looks more like a supermodel than a rough-hewn male soldier. Scenes in which men assume her gender are unintentionally funny.The new "Mulan" takes a more somber and serious tone than the original, swapping out the Eddie Murphy-voiced comic relief dragon Mushu for a CGI Phoenix, and subduing most musical moments in favor of tense, overly dry brooding.It's been a long and rough wait for superfans. Originally slated for a July 24 release, the movie was bumped to August 21, before landing September 4 on Disney+ as a early access add-on. It will be free on the app December 4, and unless you're a superfan, you're best off waiting until then.At least fans will be able to be mildly disappointed in the comfort of their own homes, and be able to hit pause if they get a little drowsy.There is impressive artistry at work. The film is every bit as gorgeous and sweeping as Disney's best live-action remakes: "The Jungle Book" and "The Lion King."Add this one to the pile of disappointing live-action remakes of Disney classics, along with "Aladdin," "Dumbo," "Alice in Wonderland," "Lady and the Tramp" and "Beauty and the Beast."The movie's legacy may well be what it does for boosting Disney's app and changing the way studios sell movies to the public. In those respects, "Mulan" is as monumental a cinematic landmark as its 1998 predecessor.It's too bad the movie itself is a snoozer.RATING: 2 stars out of 4.Phil Villarreal TwitterPhil Villarreal FacebookPhil Villarreal Amazon Author PagePhil Villarreal Rotten TomatoesThis review by Phil Villarreal originally appeared on kgun9.com. 2639
CARLSBAD, Calif. (KGTV) — Joining Oceanside and California state beaches, Carlsbad city officials announced Friday that they will close beach parking lots for the July 4 weekend.The city says that beach parking lots will be closed July 4 and 5 in Carlsbad, over concerns of crowds from counties where beaches are closed traveling to the region.Carlsbad's decision comes after a letter from the Governor's Office of Emergency Services and days after Oceanside instituted a similar beach parking closure.RELATED: Crowds flock to San Diego beaches for Fourth of July weekendEarlier this week, San Diego County Supervisors said they did not plan to mandate county beaches to close and would leave it up to cities to decide themselves."At the time of writing, beaches under the jurisdiction of local governments within San Diego County are the only beaches without visitation restrictions throughout all of Southern California, and therefore are attracting thousands of residents from outside your coastal communities and creating significant potential for disease transmission, particularly in crowded restaurants, bars, retail, and hotels," Cal OES wrote in a letter to the cities of San Diego, Imperial Beach, Coronado, Del Mar, Solana Beach, Encinitas, Carlsbad, and Oceanside. "To protect the public health of San Diegans and reduce the high potential transmission of this deadly disease in San Diego coastal businesses, we write to request that municipal governments do not open beach parking lots for the July 4th holiday weekend."Beaches in Los Angeles, Orange, Santa Barbara, and Venture Counties are closed this weekend amid surging coronavirus cases in the state.California closed state beach parking lots, including those in San Diego County, ahead of Saturday. 1776
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