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SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617

SAN DIEGO (KGTV) — Mayor Kevin Faulconer and Jewish leaders celebrated the second night of Hanukkah Monday, lighting the second candle of a massive Menorah outside City Hall.As the second night of the Jewish Festival of Lights got underway, Rabbi Zalman Carlebach said it was important for leaders to show their support and celebrate in light of recent anti-Semetic incidents around the U.S. "In light of the current events that are happening around the country, this world could use some more light. America could use some more light," said Rabbi Carlebach.San Diego has numerous Menorah lighting events planned as well as other celebrations throughout the county as Hanukkah continues — running through Dec. 10. Check out where to celebrate in San Diego here. 769

SAN DIEGO (KGTV) — It's always a good time to check on supplies and make sure you and your family are prepared for an earthquake.The County of San Diego recommends seven simple steps for earthquake safety:Fix potential hazards, like areas of your home that could pose a danger during an earthquake;Create a disaster plan with your family. The county's tips on how to handle a disaster here;Create a disaster supplies kit. The county also has tips on what to pack here;Fix your building's potential weaknesses;During earthquakes and aftershocks: Drop, Cover, and Hold-On;After the earthquake, check for injuries and damage; andWhen safe, continue to follow your disaster planSan Diego County recommends packing enough water, food, and supplies to last each member of the family at least three days. They also recommend that families practice their disaster plan so they're ready when an emergency happens.When an earthquake does happen, families should drop, find cover under something sturdy, and hold on to that cover. If there isn't anything sturdy, find an interior wall that is not near any heavy furniture or glass, scoot down and cover your head.If outside, find an open area away from buildings, trees, or anything overhead such as utility wires, sit down, and cover your head.While San Diego County has sparse earthquake activity compared to the rest of the state, one big enough can send tremors into our region.Residents can also sing up for AlertSanDiego mobile alerts from the county. Residents can also dial 2-1-1 for emergency updates. 1557

SAN DIEGO (KGTV) - It was more than a decade after two-year-old Jahi Turner disappeared.His mother, Tameka, had been posted on deployment with the U.S. Navy in 2002. Step-dad Tieray Jones claimed the boy vanished while playing with other kids at a park in Golden Hill, while Jones was buying a drink at a vending machine.Police thought otherwise, suspicious that Jones had severely punished the boy for bed-wetting and he died. The body never to be found.RELATED: Stepfather facing trial in Jahi Turner murderTameka called Tieray with detectives listening in."The accident ... is something that's an accident, ya know. Anything else what happened would have to be supposedly my fault," Tameka said.Tameka explained that she no longer trusted Tieray, saying, "I'm learning all this information that had I known years ago ... I'm sorry."RELATED: Trial begins for stepfather accused in disappearance, death of Jahi TurnerThe trial will resume o February 20. 977

SAN DIEGO (KGTV) - Investors are watching carefully to see if interest rates keep dropping, or if they may eventually dip below zero in the United States.Recently, former Chairman of the Federal Reserve Alan Greenspan said it's a possibility, as rates have remained historically low for the past few years.In San Diego, the results of a negative interest rate would be good news for some and bad news for others."Low rates are a double-edged sword," says Dennis Brewster of SagePoint Financial. "If you're a borrower, if you're looking to buy a house today, mortgage rates have never been lower. But if you're a saver and you have money in the bank or in a CD, your rates are pretty poor."Brewster says the interest rate tends to drop when growth in the US is slow, both for the population and the Gross Domestic Product. He says that's what's happening now, as the baby boomer generation is getting older and later generations have fewer children. Brewster says slower population growth leads to slower economic growth because there are fewer people in the workforce, which means company production is down, and so is spending. He says that is happening despite record low unemployment.As for negative interest, Brewster says the average San Diego shouldn't worry since it's unlikely to happen."I wouldn't change your long term plans," he says. "The economy can move forward through high or low rates." 1411