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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

BEIJING, Jan. 6 (Xinhua) -- Beijing will offer residents 20,000 rental bikes this year to ease the city's notorious traffic jams, according to authorities with the Beijing Municipal Commission of Development and Reform.Five hundred rental kiosks will be set up around the city to offer residents over 20,000 rental bikes, the commission said.Beijing has also proposed creating new bike lanes in some areas, including main streets, historical and cultural conservation areas and some major business districts, from 2011 to 2015, according to the commission.The capital city currently has about 5 million vehicles on its roads, leading to serious traffic congestion that frustrates the city's residents on a daily basis."A lack of bike lanes is the reason why I refuse to ride a bike. Bikes and vehicles are using the same lanes, and that frightens me and makes me feel unsafe," said Beijing resident Song Tao.People often park cars on the city's existing bike lanes, pushing cyclists onto the vehicles' lanes, said Song.To ease traffic congestion, Beijing has made various efforts to encourage people to opt for modes of public transportation.On Dec. 31, Beijing opened three new subway lines, bringing the number of subway lines in Beijing to 15, with a total length of 372 kilometers, said Beijing Metro Spokesman Jia Peng.Beijing will open four more subway lines in 2012, according to information released at a rail transit construction mobilization conference.Amid other measures to ease traffic in 2011, city authorities decided to allow only 240,000 vehicles to be registered annually, slashing the new car registrations by two-thirds from the 2010 level.Meanwhile, vehicles are banned from roads one day each week according to license plate numbers.

SAN FRANCISCO, Dec. 2 (Xinhua) -- Only two weeks after its shipment, Amazon's Kindle Fire has already shown the momentum to grab the second place in global tablet computer market, research firm IHS predicted on Friday.Amazon is expected to ship 3.9 million Kindle Fire tablets during the last three months of 2011, the first quarter the product goes on sale, according to preliminary projection from IHS.The number will give Amazon a 13.8-percent share of global tablet market in the fourth quarter, surpassing the 4.8 percent held by No. 3 player Samsung, and second only to Apple's commanding 65.6 percent market share."Nearly two years after Apple Inc. rolled out the iPad, a competitor has finally developed an alternative which looks like it might have enough of Apple's secret sauce to succeed," Rhoda Alexander, senior manager of tablet and monitor research for IHS, said in a statement."Initial market response strongly suggests that Amazon, with the Kindle Fire, has found the right combination of savvy pricing, astute marketing, accessible content and an appropriate business model, positioning the Kindle Fire to appeal to a brand-new set of media tablet buyers," she added.IHS analysts noted that with a price tag of 199 U.S. dollars, the Kindle Fire has set a new bar for pricing, bringing the tablet within reach of a larger portion of the buying public.IHS expects Kindle Fire's rapid ascent to help fuel the expansion of the entire tablet market, now predicting that 64.7 million tablets will be shipped in 2011, higher than its previous forecast of 60 million issued in August.The total tablet shipment number this year will represent a 273- percent growth from 17.4 million units in 2010, said IHS, which has also increased its longer-term projection of global tablet shipment in 2015 to 287.2 million units.

HOUSTON, Dec. 13 (Xinhua) -- NASA Johnson Space Center on Tuesday formed a partnership with Texas's largest tech incubator and accelerator, the Houston Technology Center (HTC), to help reach its goals of increasing private and public collaboration.The strategic partnership is aimed at expanding HTC's mission of accelerating the growth of emerging technology companies in the Houston region to support NASA's goals of increasing private and public cooperation, the parties said in news release."We are excited to partner with NASA Johnson Space Center in an effort to foster entrepreneurial opportunities to the transitioning workforce in the Bay Area," said Walter Ulrich, CEO of Houston Technology Center."The combination of NASA's incredible technologies and HTC's powerful entrepreneurial resources presents the potential for immense economic development," he said.HTC is committed to growing a sustainable entrepreneurial network that will benefit the surrounding the space center for years to come including its future missions beyond low earth orbit. HTC will seed the future workforce through its close ties with the major universities and with science, technology, engineering, math programs and objectives, according to the news release.NASA and the Houston Technology Center began their partnership earlier this year when they originally formed plans to open an office to help former contractors near the Johnson Space Center.With the signing of the Space Act Agreement on Tuesday, the two sides move forward with retraining contractors and helping them get new jobs in the Houston area.An estimated 4,000 people are expected to lose their jobs when the space shuttle program is completed.

BEIJING, Jan. 4 (Xinhua) -- Senior Chinese leader Li Changchun on Wednesday called for more efforts to strengthen the Internet construction and management and promote a healthy online culture.Li, a member of the Standing Committee of the Political Bureau of the Communist Party of China Central Committee, made the remarks at a national conference of publicity officials.Li also urged the officials to work and fortify the leading status of Marxism in the country's ideological field, and to provide spiritual support for the economic and social development.Li Changchun (C), a member of the Standing Committee of the Political Bureau of the Communist Party of China Central Committee, addresses a national conference of publicity officials in Beijing, capital of China, Jan. 4, 2012.The publicity work should help create a favorable environment for the country's efforts to stabilize economic growth, regulate commodity prices, adjust the economic structure, improve people's livelihood, carry forward reform and promote social harmony, Li said.Moreover, Li called for efforts to deepen the reform and promote development in the country's cultural sector.