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The US Coast Guard was searching Friday for a passenger who reportedly went overboard from a cruise ship about 35 miles south of the Florida Keys.The 26-year-old man was on the Carnival Victory cruise ship below Islamorada when the incident occurred, officials said.Vance Gulliksen, a spokesman for Carnival Cruise Line, said the vessel was headed back to Miami, its home port, when the man disappeared."All appropriate authorities, including the United States Coast Guard, were notified, and the ship has joined in the search and rescue efforts," Gulliksen said in a statement.Carnival Victory was completing a four-day cruise.A Coast Guard plane, helicopter and cutter were involved in the search. 707

The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The US officially relocated its Embassy to Jerusalem on Monday, formally upending decades of American foreign policy in a move that was met with clashes and protests along the Israeli-Gaza border.At least 43 Palestinians were killed in Gaza as deadly protests took place ahead of and during the ceremony in Jerusalem — making it the deadliest day there since the 2014 Gaza war.President Donald Trump did not attend the ceremony in Jerusalem's Arnona neighborhood, but in a video message broadcast at the event he congratulated Israel, saying the opening had been "a long time coming.""Today, Jerusalem is the seam of Israel's government. It is the home of the Israeli legislature and the Israeli supreme court and Israel's prime minister and president. Israel is a sovereign nation with the right like every other sovereign nation to determine its own capital, yet for many years, we failed to acknowledge the obvious, the plain reality that Israel's capital is Jerusalem," Trump said in the pre-recorded remarks. 1021

The two gamers shot dead at a tournament in Jacksonville, Florida, on Sunday have yet to be officially identified but their names are being shared by those who knew them.The Jacksonville Sheriff's Office has confirmed that two people were killed in the shooting at the GLHF Game Bar at the Jacksonville Landing Complex, an open-air marketplace with stores, bars and restaurants along the St. Johns River. Nine other people suffered gunshot wounds and two people were injured fleeing the area. The gunman then turned his weapon on himself.While the sheriff's office has not identified the two who were killed, their names have been widely reported on social media by people who were at the bar, members of the gaming community and others.One of the victims, Taylor "spotmeplzzz" Robertson was identified by his gaming sponsor, Dot City Gaming. 850

The Washington Post has published what the newspaper describes as the "last piece" written by missing Saudi journalist Jamal Khashoggi, who was allegedly killed and dismembered in his country's consulate in Istanbul earlier this month.In a note at the top of the column, published late Wednesday, Post Global Opinions editor Karen Attiah wrote that she "held off publishing it because we hoped Jamal would come back to us.""Now I have to accept: That is not going to happen," she said. "This is the last piece of his I will edit for The Post. This column perfectly captures his commitment and passion for freedom in the Arab world. A freedom he apparently gave his life for."In the piece, Khashoggi bemoaned the lack of free expression in the Arab world, leaving the majority of its population "unable to adequately address, much less publicly discuss, matters that affect the region and their day-to-day lives." 930