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CHARLOTTESVILLE, Va. - At the ripe age of 74, scientist Wladek Minor, PhD. is not slowing down anytime soon, especially when it comes to his research to better understand COVID-19.“This is the biggest danger I’ve seen in my lifetime,” said Minor. “This is a real danger, and we shouldn’t underestimate it.”Minor, who is also a professor at UVA’s Department of Molecular Physiology and Biological Physics, recently made a new discovery in the fight against coronavirus.As the lead researcher, Minor and his team of scientists recently discovered a link between a coronavirus treatment and people with diabetes.They found the drug dexamethasone, which is used to lower the risk of death in patients with a severe case of the virus, might be less effective for treating patients with diabetes.“We were trying to explain why the action of dexamethasone is somewhat erratic,” Minor said. “It means it works for some people and [does] not necessarily work for other people.”Minor and his team analyzed data from 373 COVID-19 patients at a hospital from Wuhan, China.Their research determined how a type of protein in our blood, called serum albumin, picks up dexamethasone and carries it through the body.The scientists found that patients who died had lower levels of that protein than those who survived.Those who died also had higher levels of blood sugar, suggesting diabetes may make it difficult for patients to get the benefits of the drug.“We are trying to make as much impact on human life as possible,” said Minor.Dexamethasone has been shown to cut deaths by about 30% for COVID-19 patients who were on ventilators.The steroid was used to help treat President Donald Trump’s bout with the virus, along with other treatments and drugs including remdesivir, which was just approved by the FDA to use on all hospitalized patients.“COVID is now our enemy, and really, it’s the biggest enemy,” Minor said.Scientists said more research is needed to determine the best treatment for COVID-19 patients, especially for those who have diabetes.For more information on Minor’s research, click here.This story was first reported by Antoinette DelBel at WTKR in Norfolk, Virginia. 2180

CHAFFEE COUNTY, Colo. — Almost three weeks after a fatal crash that sent a golden-doodle running near Pueblo, Colo., a family has him back in their arms.The family, who was visiting from Wichita, Kansas, had been driving along the edge of a mountain west of Pueblo on Aug. 7, when their vehicle slid off the edge and tumbled 600 feet down an incline, according to the Associated Press. The crash killed Jennifer Orr and seriously injured her 21-year-old daughter, Samantha. The 1-year-old family golden-doodle, Bentley, was thrown from the vehicle and ran away from the crash.In the days after the crash, the family created and actively posted on a Facebook page Bring Bentley Home to try to find the dog. When Samantha Orr was released from the hospital, she returned to the crash site to search for Bentley. Her family posted their thanks and pleas for help every few days on the Facebook page.  On Saturday evening, Samantha Orr posted an update she had been waiting for for 19 days.  In the video, she’s tear-eyed and hugging Bentley.“My heart is BURSTING,” she wrote on Facebook. “Thank you from the bottom of my heart to everyone who shared, liked, handed out flyers, spread the word, or sent kind words, or any of the millions of ways people have shown their kindness since the accident. The world has so many amazing people in it, I am SO unbelievably grateful.”Bentley was found early Saturday after Orr and others returned to the site.  They spotted him and encouraged him to walk over with food and a toy, according to the AP. He was reluctant at first, but Orr said they slowly moved toward each other. A video captures the reunion.“Good boy, good boy, come here, baby,” Orr said. “Come here Bentley-boo, come here baby boy.”After some encouragement, the dog walked over a patch of rocks to Orr.“And from then it was nothing but tears and celebration!” the post reads. “Bentley is okay, he’s a little malnourished and dehydrated. But otherwise no noticeable injuries. Thank you to everyone who played a role in bringing this sweet boy home. I know the past 19 days, God and my beautiful momma have been keeping an eye on him.” 2176

CAPE CORAL, Fla., -- A man accidentally discharged his semiautomatic hand gun Friday while shopping for ammunition inside the retail portion of Shoot Center, a gun store in Cape Coral. "We always assume you have a loaded firearm," said Shoot Center Owner, Aaron Forum, describing store protocol for anyone that pulls out a gun.  Forum took to Facebook to explain the incident:  405

Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

CHATTANOOGA, Tenn. – Spy, prisoner of war, patriot – at one time or another, all those words described Dr. Mary Walker, a practicing surgeon for the Union Army during the Civil War.“She was a woman ahead of her time,” said Keith Hardison, director of the Charles H. Coolidge National Medal of Honor Heritage Center in Chattanooga, Tennessee.Now, though, Dr. Walker’s time has come. She is the focus of a new special exhibit at the center.“Dr. Walker wanted to go where the fighting was bloodiest,” said exhibit curator Molly Randolph. “She tried multiple times to join up and was denied.”Yet, she persisted and volunteered her medical skills to Union commanders during the Civil War. They put her to work – for no pay – on the front lines.That’s when her career as a spy began.“She used that cover of going into the countryside and providing medical care to do some espionage,” Randolph said.Eventually, the Confederate Army captured her and held her as a prisoner of war for four months, where she became well-known for wearing her trademark pants.“She was rather notorious,” Randolph said. “She was written up in the Confederate papers. Everyone thought this, you know, doctor - a female doctor who wore pants! - was a thing to poke fun at a little bit.”Suffering severe malnourishment at the Confederacy’s notorious “Castle Thunder” prison, Dr. Walker was eventually released in a prisoner exchange.“She was actually exchanged for a Confederate doctor, which she loved. She loved that she was worth so much to the federal forces,” Randolph said.Dr. Walker returned to the front lines to provide medical care for the Union Army. When the war ended, President Andrew Johnson awarded her the Medal of Honor.She became the first woman to ever receive it and – so far – remains the only one.“I’m surprised there’s only been one,” said Tom Jones, who was visiting the Medal of Honor Heritage Center from Illinois. “I know there’s not been a lot of women in combat, but they’ve been serving since the Civil War, obviously.”In 1917, the military instituted new rules for awarding the Medal of Honor and stripped Dr. Walker of hers because, technically, she had not been formally enlisted – though she had repeatedly tried to sign up.She died two years later, in 1919.“She refused to return it and continued to wear it,” Randolph said. “So, it was obviously something that was incredibly important to her.”Six decades later, a military board and President Jimmy Carter would once again reinstate her medal.“She was willing to challenge things that were unfair or that were convention, but were holding people back,” Hardison said.Dr. Walker was a lifelong suffragist. Her exhibit coincides with this summer’s 100th anniversary of the 19thAmendment, which granted women the right to vote in the U.S. It’s an amendment she didn’t live long enough to see become a reality.Her exhibit’s curators hope she will remind others of how to face life’s challenges.“She really shows us how to respond with poise, with gusto, with dignity,” Randolph said, “and I think Dr. Walker is just a wonderful example.”For more information on the exhibit about Dr. Mary Walker, click here. 3168