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WASHINGTON, Dec. 21 (Xinhua) -- The U.S. Food and Drug Administration (FDA) on Wednesday approved Isentress for the treatment of HIV-1 infection for children and adolescents.The drug is part of a class of medications called HIV integrase strand transfer inhibitors that works by slowing the spread of HIV in the body. It was first approved for use in adult patients in October 2007, under FDA's accelerated approval program."Many young children and adolescents are living with HIV and this approval provides an important additional option for their treatment," said Edward Cox, director of the Office of Antimicrobial Products in the FDA's Center for Drug Evaluation and Research.Isentress is a pill that can be taken twice daily, with or without food. The pill is also available in a chewable form. As the two tablet formulations are not interchangeable, the chewable form is only approved for use in children ages 2 to 11.A single, multi-center clinical trial of 96 children and adolescents aged 2-18 years with HIV-1 infection evaluated the safety and effectiveness of Isentress. These patients previously received treatment for HIV-1 infection. After 24 weeks of treatment with Isentress, 53 percent of these patients had an undetectable amount of HIV in their blood.According to the FDA, the most commonly reported severe, treatment-related side effects in patients taking Isentress include trouble sleeping and headache. The frequency of these side effects is similar for children and adults. One pediatric patient reported severe treatment-related insomnia, while another pediatric patient experienced a drug-related skin rash.

CANNES, France, Nov. 3 (Xinhua) -- Chinese President Hu Jintao met here Wednesday his French counterpart Nicolas Sarkozy on bilateral ties and other issues of common concern, including the Group of 20 summit scheduled for Thursday and Friday.Hu pointed out that since the global economic recovery is now burdened by quite a few instable and uncertain factors, the international community has great expectations of the G20 Summit in Cannes."The Chinese side actively supports the French side to host the summit," Hu said, emphasizing that the G20 should continue to uphold the spirit of cooperation and send a clear and definite signal of securing growth and promoting stability to the international community through this summit.Hu expressed the hope that all relevant parties should jointly endeavor to make the Cannes summit a conference of solidarity and win-win cooperation.Sarkozy expressed his appreciation of the effort China has made to prepare for the G20 summit. He said the French side was ready to strengthen coordination and cooperation with the Chinese side and work with all other parties to push for positive results at the summit.Hu said Europe is the largest economy in the world, and there will be no global economic recovery without a recovery of the European economy.He pointed out that the package deal that the European Union (EU) struck lately demonstrates its will and determination to resolve Europe's debt problem. He hoped that the implementation of the package deal would help overcome the difficulties facing Europe and be conducive to the recovery and growth of the European economy."It is mainly up to Europe to resolve the European debt problem," Hu said."We believe that Europe has all the wisdom and capability to resolve the debt problem," he added.Sarkozy said Europe is committed to resolving the debt crisis by making its own effort and strengthening cooperation with the international community. Hu said China wants to see Europe prosper.Noting that it was the third time for him to meet Sarkozy so far this year, Hu said the two sides had a frank and in-depth exchange of views on bilateral links, world economic situation, G20 affairs and major international issues and reached many important consensuses.The development of China-France relations has maintained good momentum recently. President Hu paid a state visit to France in November last year and met Sarkozy in March and August this year when the French president visited China.Hu said China places importance on developing its relations with France and the EU. He also thanked Sarkozy for France's meticulous preparation for the G20 summit and its hospitality to global leaders.France values China's role and appreciates its focus on major international issues, Sarkozy said, adding that his country is willing to maintain close communication and consultation with China.

BEIJING, Oct. 26 (Xinhua) -- The State Council, or China's cabinet, has decided to create a food allowance for about 26 million needy students nationwide, according to a statement issued on Wednesday.Each student will receive an average of three yuan (47 cents) daily from the central budget, said a statement issued after a State Council meeting presided over by Premier Wen Jiabao.The policy will be implemented on a trial basis in 680 less-developed counties, the statement said.Authorities will have to allocate a total of 16 billion yuan annually from the central budget to meet the policy's requirements, it said.The money will be given to schools instead of directly to the students' families, allowing the schools to provide more and better food in their canteens, the statement said.Efforts will be made to build better canteens in rural primary and middle schools, the statement said.The statement added that daily allowances for needy students at primary boarding schools will also be increased from three to four yuan, while those for students at middle boarding schools will rise from four to five yuan.

SAN FRANCISCO, Nov. 1 (Xinhua) -- Apple announced on Tuesday that its latest iPhone 4S smartphone will be available in China's Hong Kong, South Korea and 13 additional countries next Friday.Customers will be able to pre-order iPhone 4S beginning this Friday, the Cupertino, California-based company said in a statement.The other 13 countries are Albania, Armenia, Bulgaria, El Salvador, Greece, Guatemala, Malta, Montenegro, New Zealand, Panama, Poland, Portugal and Romania.So far, some owners have been complaining about the shorter battery life on their new iPhone 4S handsets. Apple is reportedly investigating the issue and has not made official comments yet.The iPhone 4S looks the same as the previous iPhone 4 but has major hardware upgrade inside. Apple announced sales of more than four million units of iPhone 4S in the three days after its launch in the United States on Oct. 14.The iPhone 4S now is available in 29 countries and is expected to arrive in stores in more than 70 countries by the end of this year.

WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.