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SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) -- The National Weather Service warned of minor coastal flooding ahead of a King Tide set to hit the San Diego County coastline Monday and Tuesday.The event forced the agency to issue a beach hazards statement from Sunday night through Tuesday evening.Surf will begin to build late Sunday, peaking Monday and Tuesday. By Tuesday night, the surf is expected to diminish, the agency said.High tides Monday will be 6.9 feet at 8 a.m. High tide on Tuesday will be 6.8 feet at 8:40 a.m.The agency warned that the King Tides will create water run-up into some beach parking lots and other low-lying areas.Beaches most prone to flooding include Sunset, Seal, Newport, Oceanside, Cardiff, La Jolla Shores and Imperial Beach.Elevated surf will also create strong rip currents and dangerous swimming conditions, the National Weather Service says. 861

SAN DIEGO (KGTV) — The California Department of Motor Vehicles is delaying some driver license and vehicle registration services for 60 days due to the coronavirus pandemic.The DMV said the action will protect customers from coming to offices and employees who are working in office during the outbreak."The DMV is taking this action so that at-risk populations, including seniors and those with underlying health conditions, can avoid required visits to DMV field offices for driver license or vehicle registration renewals," the DMV said in a release.RELATED COVERAGE:California COVID-19 Tracker: San Diego coronavirus updatesSan Diego County leaders set up community response fund amid coronavirusList: School districts providing free meals amid closuresThe 60-day reprieve begins March 16 and covers some services that require an office visit for new driver licenses, duplicate driver licenses, some driver license renewals, new license plates, complex vehicle registrations or title transfers, and off-highway permits.Transactions that fall within this period include driver license renewals for those:70 years of age and older, who are required to take a knowledge testIndividuals who are required to renew in the office (last DMV visit was 15 years prior)Individuals subject to vision testingIndividuals with complex driving historyThe 60-day period also applies to vehicle registration renewals for customers who are not eligible to use an alternative service channel because of:Outdated insurance informationRegistration expired for 90 days or moreSmog issuesA recent transferSeveral DMV tasks can still be completed online through the department's website or at its kiosks around the state. The DMV is also recommending that state law enforcement be flexible when reviewing driver license or identification and vehicle registration. The DMV said it may choose to waive registration penalties, as well.California's DMV offices are open amid several closures around the state due to the coronavirus, but are working to increase access to services outside the office. 2082

SAN DIEGO (KGTV) -- The leader of a San Diego motorcycle gang pleaded guilty Tuesday to participating in a scheme to seal dozens of Jeep Wranglers in San Diego County. Jimmy Josue Martinez, a leader of the Hooligans motorcycle gang, pleaded guilty Tuesday, admitting to participating in the scheme. According to court records, the gang is responsible for the theft of more than 150 of the vehicles since 2014, totaling about .5 million. Records show that the Hooligans used high-tech methods to disable security systems and steal the Jeeps before taking them to Tijuana to be sold or stripped for parts. RELATED: Three arrested, 6 sought in San Diego Jeep Wrangler theft ringAs part of the plea agreement, Martinez admitted to stealing the Jeeps in Pacific Beach, Serra Mesa, Chula Vista, Mission Valley, Ocean Beach, Hillcrest and North Park. Martinez and members of his crew would obtain the vehicle identification number in advance before getting secret key codes which allowed them to create a duplicate key for a particular Jeep. “The joy ride is over for Mr. Martinez,” said U.S. Attorney Robert Brewer. “These thefts were audacious and sophisticated and created hassle and heartache for scores of Jeep owners. I congratulate prosecutors Andrew Galvin and Joseph S. Green, the FBI and members of the Regional Auto Theft Task Force for putting together a strong case against a gang that, unfortunately, has lived up to its name.”Along with Martinez, eight other members of the gang were charged in a grand jury indictment in 2017. Of the nine charged, six have pleaded guilty and three are fugitives. 1616

SAN DIEGO (KGTV) — The holiday season will be bright and alive with the sounds of bands and cheers this season.Several parades will return to San Diego in the next month, from the traditional Mother Goose Parade in El Cajon to the seasonal wrap-up with the Holiday Bowl Parade.And in between, even more festive entertainment across the county, as floats, marching bands, vintage cars, and performers get communities excited for the holidays.RELATED:Skate away on one of San Diego's outdoor ice rinks this holiday seasonSan Diego holiday tree lightings to catch this seasonTurkey trots, holiday runs in San Diego this seasonNov. 2473rd annual Mother Goose Parade: El Cajon's annual Mother Goose Parade hits the streets at 1 p.m., following Main Street from El Cajon Blvd. to 1st Ave. Each "Chapter" of the parade brings several floats and bands down the parade route for onlookers, all leading up to Santa's arrival.Dec. 6Coronado Holiday Parade: Coronado rings in the holidays with their annual parade at 6 p.m., with festival floats and performers making their way down Orange Ave., bringing Santa to the town's Christmas tree for a special lighting ceremony.Dec. 7Chula Vista Starlight Parade: Chula Vista's Starlight Parade begins at 5 p.m., as Third Avenue hosts vintage cars, marching bands, dancers, and more to kick off the holiday season in the South Bay.Encinitas Holiday Parade: For the 62nd year, Encinitas will see thousands gather to watch cars, floats, and marching bands head down Coast Highway 101 during the Encinitas Holiday Parade at 5:30 p.m. This year's theme is "Encinitas on the Move!"Ocean Beach Holiday Parade: OB's holiday parade kicks off at 5:05 p.m. on Newport Ave. under this year's theme of "Miracle on Newport Ave.!" Floats will also compete in categories for best lights, unusual float, and OB spirit!Dec. 8North Park Toyland Parade: Holiday magic comes alive at 11 a.m. in North Park as their annual Toyland Parade brings a display of festival bands, floats, and cars down University Ave., between Utah and Iowa Streets.La Jolla Christmas Parade: La Jolla celebrates the magic of Christmas starting at 11 a.m. during their annual Christmas Parade, this year under the theme "Christmas on the Moon." The parade will travel down Girard Ave. and Prospect St.San Diego Bay Parade of Lights: Boats dressed in lights and colorful decorations will glide along the San Diego Bay Parade of Lights before thousands of onlookers beginning at 5 p.m. each night. This year’s theme will be Comic-Con on the Bay.Dec. 14Mission Bay Christmas Boat Parade of Lights: Dozens of boats in their best holiday decor will hit the waters of Mission Bay for their own special parade beginning at 6 p.m., traveling between Vacation and Fiesta Islands.Oceanside Harbor Parade of Lights: Oceanside has its own celebration of the holidays on the water, as their Parade of Lights brings boats dressed in colorful lights and decorations to the harbor beginning at 7 p.m.Dec. 15Gaslamp Holiday Pet Parade: Pooches and felines will deck the paws in the Gaslamp District, as the annual Holiday Pet Parade makes its way down Fifth Ave. under the Gaslamp archway starting at 2 p.m.San Diego Bay Parade of Lights: (Second running) Boats dressed in lights and colorful decorations will glide along the San Diego Bay Parade of Lights before thousands of onlookers beginning at 5 p.m. each night. This year’s theme will be Comic-Con on the Bay.Dec. 26San Diego Holiday Bowl Parade: America's largest balloon parade returns to San Diego, as the Holiday Bowl Parade invites more than 100,000 out to watch marching bands, floats, drill teams, and, of course, balloons starting at 10 a.m. 3685

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