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WASHINGTON, Oct. 13 (Xinhua) -- U.S. researchers have corrected sickle cell disease in adult laboratory mice that had been bred to have the inherited blood disorder by activating production of a special blood component, according to a study published online Thursday in the journal Science.Sickle cell disease results from an abnormality in hemoglobin, the protein found in red blood cells that is responsible for transporting oxygen throughout the body. People living with sickle cell disease have two copies of an altered gene that produces sickle hemoglobin instead of normal adult hemoglobin. Sickle hemoglobin changes shape after releasing its oxygen, causing the red blood cell to become stiff, misshapen and sticky, and slowing blood flow to tissues. This process damages organs and causes pain.The study tested a new approach to increasing the production of a third form of hemoglobin -- fetal hemoglobin. Production of fetal hemoglobin predominates before birth, but turns off thereafter as adult hemoglobin production takes over. People with sickle cell disease are unable to make normal adult hemoglobin, and instead make sickle hemoglobin starting in infancy.An elevated level of fetal hemoglobin within the red blood cell reduces the tendency of sickle hemoglobin to change the shape of red blood cells. Considerable research has shown that the drug hydroxyurea increases production of fetal hemoglobin and reduces the number of pain crises and other complications of sickle cell disease in adults and children. However, not all patients respond well to hydroxyurea, and adverse side effects are a concern.The current study explores a more targeted approach to increasing fetal hemoglobin production. It builds upon earlier studies that discovered a protein called BCL11A normally suppresses the production of fetal hemoglobin soon after birth. The researchers viewed the BCL11A protein as a target for therapy and decided to see what would happen if they blocked production of the protein.The paper details how the research team silenced the mouse gene that produces the BCL11A protein in mice with sickle cell disease. Silencing the gene turned off production of the BCL11A protein and allowed the adult mice to continue to produce fetal hemoglobin. It appears to have eliminated disease symptoms without affecting other aspects of blood production."This discovery provides an important new target for future therapies in people with sickle cell disease," said Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, which co-funded the study. "More work is needed before it will be possible to test such therapies in people, but this study demonstrates that the approach works in principle."Approximately 100,000 Americans live with sickle cell disease. It is most prevalent in people of African, Hispanic, Mediterranean, and Middle Eastern descent. There is no widely available cure for sickle cell disease. Bone marrow transplants have cured some patients, but the treatment is not without risk and most patients do not have relatives who can donate compatible and healthy bone marrow to them.

BEIJING, Otc. 26 (Xinhuanet) -- The more coffee people consume, the less likely they develop the most common form of skin cancer, a new study suggests, according to media reports Tuesday."Our study indicates that coffee consumption may be an important option to help prevent basal cell carcinoma," stated Fengju Song, lead researcher of the study and a postdoctoral fellow in the department of dermatology at Brigham and Women's Hospital and Harvard Medical School in Boston.Basal cell carcinoma (BCC) is reported to be a slow-growing form of skin cancer that accounts for 75 percent of all skin cancers. It is the most common type of skin cancer, with nearly one million new cases diagnosed each year in the United States.Although BCC is hardly fatal, if ignored, there may be consequences of treatment, including disfigurement, according to a USA Today report.The US researchers found that women who drank over three cups of coffee a day were 20 percent less likely to develop BCC, whereas the risk of having BCC for men who consumed more than three cups per day lowered 9 percent.To get the findings, the researchers analysed data from almost113,000 people between1984-2008 and over 23,000 were diagnosed with BCC.The researchers agreed that caffeinated coffee was associated with BCC risk reduction, but decaffeinated coffee did not have such effect.According to a Fox News report, besides cutting the risk of skin cancer, coffee consumption has also been found to lower the risk of breast cancer and prostate cancer and cancer overall."To the best of our knowledge, coffee consumption is a healthy habit," said Fengju Song, cited by the Fox News.The findings were presented Monday at the American Association for Cancer Research International Conference in Boston and not yet published in a scientific journal.

JERUSALEM, Nov. 1 (Xinhua) -- Israeli researchers at Tel Aviv University developed a computer chip that could recuperate loss body movement if placed in the cerebellum, opening the doors to treatment of brain damage, researchers told Xinhua on Tuesday.The computer chip, wired to a man-made segment of a cerebellum, was attached to a rodent's skull that had lost the ability to blink. After the artificial cerebellum was implanted, the rodent was once again able to blink.The chip, connected to the rat's brain, works by reading sensory information from the body and then communicating it to the cerebellum, the area of the brain that allows movement coordination, through electrodes."The chip itself imitates a small part of the cerebellum, a very tiny part of it," said Prof. Matti Mintz of TAU's Department of Psychology."We took a small part of the cerebellum and studied it and created the computer chip that mimics the damaged area," he said.However, more complicated movements, like walking, are still at least one decade away, Mintz added."We still did not test it on humans because we need to know the area the chip will mimic before installing it, which requires extensive research. But we are now developing a chip that will do a sequence of simple movements," he pointed out.When fully developed for humans, it can be used to help patients who suffer brain genetic diseases like Parkinson, or had strokes that caused brain damage.

KUNMING, Nov. 30 (Xinhua) -- More than 10,000 new HIV infections were reported in southwest China's Yunnan province during the first 10 months of this year, bringing the total number of HIV carriers and AIDS patients in the province to more than 90,000, local AIDS prevention authorities said Wednesday.As of Oct. 31, a total of 93,567 HIV infections had been reported in the province, with the disease claiming 14,340 lives, according to statistics from the Yunnan AIDS Prevention Bureau.The number of HIV infections contracted through sexual contact has been rising and sexual contact is now the main cause of the disease's proliferation, said Xu Heping, director of the bureau.Of the province's infected population, 45.8 percent contracted the disease through sexual contact, while 37.3 percent contracted the disease through intravenous drug abuse, according to the bureau.Sexually transmitted infections accounted for 77.3 percent of new infections during the January-October period, up from 71.3 percent during the same period last year, according to the statistics.Xu said this year's new infections mainly occurred in people between the ages of 20 and 39, accounting for 60.8 percent of the total.Infections among rural residents and unemployed people accounted for 55.3 percent and 18.6 percent, respectively, of this year's total, according to Xu.Lu Lin, director of the Yunnan disease control and prevention center, said migrant workers are particularly vulnerable to the disease due to their nomadic nature and lack of knowledge about the disease.China currently has 346,000 registered HIV carriers and AIDS patients, although the actual number is predicted to hit 780,000 by the end of this year, according to an expert panel consisting of members of China's Ministry of Health (MOH), the World Health Organization and UNAIDS.

UNITED NATIONS, Jan. 19 (Xinhua) -- China's Permanent Representative to the UN Li Baodong said here Thursday that caution should be called for in metering out sanctions in international affairs.Li made the remarks when addressing a Security Council open debate on the question of justice and rule of law."We are in favor of improving the UN sanction regime on the basis of extensive consultations so as to improve its credibility, procedures and establishing effective monitoring mechanisms and to establish strict criteria, define timelines, " Li said."Sanctions should be only carried out on basis of facts and evidence. Double standards must be avoided. Impacts against civilian lives and social economic development must be minimized," the ambassador said.Stressing that the UN chart and the fundamental principles of international law as established in it should be upheld, Li said rule of law in international relations should be strengthened.The Charter as well as principles of international law established in it constitute the call of rule of law in international relations and represents the bedrock for developing rule of law in international relations, he said."In the conduct of international relations and international affairs, adherence to the Charter and other fundamental principles of international law, such as respect for national sovereignty, non-interference in internal affairs, fulfillment in international obligation in real earnest is the essence of promotion of international rule of law," said Li.According to the Charter, UN Security Council resolutions constitute the integral part of international rule of law. Promotion of international rule of law requires strict implementation of the Security Council resolutions by member states, he added.