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CLEVELAND — Scientists at the Cleveland Clinic Lerner Research Institute have successfully reversed Alzheimer's disease in mice.According to a news release, the researchers reversed the formation of harmful plaque in the mice's brains by gradually reducing an enzyme called BACE1, improving their mental function.“To our knowledge, this is the first observation of such a dramatic reversal of amyloid deposition in any study of Alzheimer’s disease mouse models,” says Riqiang Yan, one of the scientists on the team. The study raises hopes that drugs aimed at this same enzyme will soon be able to treat Alzheimer's disease in humans. You can read the full study in the Journal of Experimental Medicine here. 735
CLEVELAND — Who’s been at a store buying holiday gifts and then the cashier asks, “do you want to sign up for our credit card today?” They might offer a discount or something else, but should you sign on the dotted line?“They make it easy. They really make it easy,” Leanne Smith said.Smith is from Solon and knows how stores can tempt you with their credit cards, but she’s sticking to her Target Red Card for now.“I don’t think it’s a responsible thing for me to have one at every store,” she said.Tedd Rossman from CreditCards.com said that if you ever plan on carrying a balance, store cards aren’t going to be the best option for you.“While sometimes these store cards can work for you, most of the time, they’re not the most consumer-friendly option,” Rossman said.That’s because Rossman says the average store credit card has an interest rate of 25%, some as high as 29.99% such as Discount Tire, Big Lots and jewelry store cards like Kay Jewelers.“These cards are not as selective about credit quality, which is why the retailers and their bank partners say they have to charge such high-interest rates,” Rossman said.CreditCardInsider.com recently rated various popular store cards based on various things like interest rates.Here are those results:Target - 24.4%Old navy - almost 26% (25.99%)Walmart - roughly 18-27% (17.99%-26.99%) interestNathan Grant from CreditCardInsider.com said you shouldn’t just sign-up at the checkout on a whim even if there’s a discount offered or cashback incentives.“The percentage of interest you’re paying might end up calculating to be more than what you got from spending on the cards,” Grant said.According to Grant, some of the better retailer cards are:Amazon prime cards with lower interest rates—5% back on Amazon purchases and gift cards when you sign up. Target—higher interest rate, but 5% back. And the only one rated excellent is Costco’s card, which has a 15% rate and various cash back options and good rewards on gas purchases.But keep this in mind: In a survey of nearly 3,000 shoppers nationwide, more than 40% said they regretted signing up for a retail credit card. Plus, one out of five in the survey said they carried a balance from the last holiday season, and more than 50% said they’ve paid interest on a retail store card.“That’s kind of like a wake-up call even to myself to be like I got to make sure that I’m always smartly shopping if I’m using credit cards,” Grant said.For Smith, she said she’s only carried a balance a couple of times in the past 20 years because she knows “if you can’t pay it, you really shouldn’t buy it just because you have a credit card.”Retail credit cards can give you benefits especially if you’re loyal to the business. It could help you build credit, but you’ll want to pay off your balances every month and spend responsibly.And another thing to watch out for is deferred interest. Even if you owe just one dollar by the time the term ends, you could end up paying interest on the entire amount you initially financed.This story originally reported by Jonathan Walsh on News5Cleveland.com 3102

CORONADO, Calif. (KGTV) -- A 21-year-old sailor died after falling from the USS Nimitz Friday night. According to U.S. Naval Air Forces, the sailor fell from one of the ship’s aircraft elevators. The USS Nimitz was in port at Naval Air Station North Island. The 21-year-old suffered serious injuries from the fall and died Saturday morning, according to the Navy. The name of the sailor hasn’t been released at this time and the nature of the accident is under investigation. A sailor from USS Nimitz passed away early this morning from injuries sustained in an accident aboard ship last night. The sailor fell from one of the ship’s aircraft elevators in a down position. The accident is under investigation.— flynavy (@flynavy) September 28, 2019 757
CLEVELAND, Ohio - A local Tuskegee Airman who served in World War II was honored and celebrated in a special way on Thursday.Asa Newman who was part of the Tuskegee Airmen— the first African American unit to fly combat airplanes in World War II—recently turned 102 years old.To celebrate this American hero, community members lined the street as law enforcement honked their horns and a crowd waved across the street to Newman.The Aurora Post of the American Legion was there to honor Newman who was surrounded by family and friends.Newman grew up in Cleveland and attended East Cleveland High School. After World War II, he moved to Chicago and attended college at Roosevelt University. He was one of seven children, with three brothers and three sisters. He is the last survivor of his immediate family. His niece, Rae Ellen, lives locally.This story was first reported by Rob Powers and Kaylyn Hlavaty at WEWS in Cleveland, Ohio. 940
Cyber Monday shoppers may also want to consider refurbished gifts.Monday, U.S. PIRG released its “Fixed for the Holidays” update. It found the variety has expanded greatly since the last report two years ago.There are options like refurbished smartphones, vacuums or professional cameras.“The deals and the quality have gotten a lot better, and in fact some of the refurbishers have told us that they've seen a significant increase in their operations over the course of the pandemic,” said Nathan Proctor, Director of U.S. PIRG's Right to Repair campaign.Refurbished products can be a great alternative for new devices that are hard to find amid manufacturing disruptions caused by the pandemic. Plus, the savings can be significant. Most of the time, they’re even better than the discounts on Black Friday.Buying refurbished is also a green option because it cuts waste.Many of the big retailers do their own refurbishing. There's also certain websites U.S. PIRG recommends, like The Store, Back Market, and Gazelle. They have extensive quality checks and great coverage options.“We recommend some of the retailers we do because the warranties are so good. I mean you can get a product with a longer warranty from the refurbisher than the new equipment manufacturer provided,” said Proctor.When shopping refurbished, learn how the site differentiates its products. Then, decide what balance you're looking for.Some products may be less expensive but have more cosmetic issues like scratches and dings. Others were returned without ever being opened.Look for brands with a reputation for higher quality.A good rule of thumb is if it was cheaper when it was new, it's higher risk as refurbished. 1703
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