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As we're all focused on the current rollout of the COVID-19 vaccine, a technology known as thin-film freezing is getting a lot of attention. It's groundbreaking and could change the way we administer drugs or use medicine in general.You've probably heard about the need to keep the COVID-19 vaccine cold. It has to be so cold, in fact, that the shipment and transport are challenging. Well, what if that vaccine could be turned into powder?“What we’ve most recently been working on is the elimination of cold chain by storing as a powder, a dry powder where the drug is much more stable than if it was stored as a liquid or as a frozen liquid,” said co-inventor Dr. Robert Williams.Williams said it would eliminate the need for extreme cold storage and transport. The technology isn't new. He got a research grant and came up with it about 15 years ago.Williams, who is also a pharmacy professor at the University of Texas in Austin, said they were working on the technology and its multiple uses when the pandemic hit. And all of a sudden, they got a lot of attention.“We have published over 70 papers on the technology and using it for different products- it’s quite a mature process," Williams said. "We developed it because with other vaccines, the majority of the vaccine cost is in wastage because of this cold chain issue, so we published several key papers where we showed our thin-film freezing technology would protect vaccines - and you wouldn’t need cold chain storage.”Glenn Mattes, President, and CEO of TFF Pharmaceuticals added that the powders can be converted to topical preparations and they are currently working with the US Army to take some of the preparations and would then administer them directly through the eye.TFF is launching thin-film freezing into development through the FDA process. “I use the term ubiquitous because it is and disruptive because it is,” Mattes said. He added that they've explored their technology in the cannabinoid realm. But, as for the COVID vaccine, they're aiming for a second-generation usage.“To truly eradicate the pandemic, you have to have a global response," Mattes said. "The companies we’ve been speaking to certainly recognize the broad utilization of the technology but the application to the developing world, rural area, remote areas, where you can take a powder and inhale it or take the powder and reconstitute it has tremendous potential."Experts say it is only just the beginning as they launch their technology into a new world. 2511

Authorities believe they have found a package addressed to former Vice President Joe Biden that was considered suspicious due to its similarities to other packages sent this week to prominent Democrats and CNN, law enforcement officials said Thursday.The package was misaddressed and returned to sender, two law enforcement sources previously told CNN.Also on Thursday, a suspicious package addressed to actor-director Robert De Niro was reported at the Manhattan building where his production company is based, and its marking and contents appear similar to pipe bomb packages recently mailed nationwide to top Democrats, two law enforcement sources said.Law enforcement authorities are treating the series of bombs as a domestic terror matter and are advising the public to remain vigilant.Devices sent to former President Barack Obama, Hillary Clinton, former Attorney General Eric Holder, California Democratic Rep. Maxine Waters and Democratic donor George Soros showed the presence of a sulfur substance, which could have exploded, a law enforcement official said.The devices are believed to be pipe bombs, inherently unstable, and at risk of being set off just by handling.The FBI's counterterrorism division is leading the investigation Thursday into the packages and the agency says it's possible additional packages were mailed to other locations.The motive is unknown, but the recipients are all prominent targets of right-wing criticism and, in many cases, of President Donald Trump himself. The package found at CNN's New York bureau in the Time Warner Center was addressed to former CIA Director John Brennan, city and local law enforcement officials said.At the White House, Trump vowed Wednesday that "we will spare no resources or expense" to pursue the perpetrator.The-CNN-Wire 1803

BALTIMORE — A doctor described as providing care to the "sickest patients" in Baltimore died of COVID-19, Mercy Medical Center said in a Facebook post.Dr. Joseph J. Costa, the chief of critical care at the hospital, was 56 years old."Joe was more than a trusted colleague; he was also a true friend to many. He dedicated his life and career to caring for the sickest patients. And when the global pandemic came down upon us, Joe selflessly continued his work on the front lines—deeply committed to serving our patients and our City during this time of great need. His memory will live on as an example to us all," the hospital said in a Facebook post.Costa joined Mercy in 1997 and became Chief of Critical Care in 2005. From 2010 to 2016 he served as an officer of the Mercy Medical Staff, culminating with his 2-year tenure as President of the Medical Staff."Joe was admired and respected among providers throughout the Baltimore region for his clinical expertise. He was beloved by his patients and their family members—known for his warm and comforting bedside manner as well as his direct and informative communication style. When he counseled our patients and families, he did so with great compassion and empathy. For all the nurses and staff who worked closely with Joe on the Intensive Care Unit, he was like an older brother that all admired and revered," the post continued.Read the full letter below. Dear Friends of Mercy, It is with great sadness that we mourn the loss of Joseph J. Costa, M.D., Chief, Division of...Posted by Mercy Medical Center, Baltimore, MD on Saturday, July 25, 2020 This story was originally published by Brandon Ingram on WMAR in Baltimore. 1702

As vaccinations get underway in the United Kingdom, United States and other rich countries who could afford to pre-purchase doses of the COVID-19 vaccines, researchers warn that about a quarter of the world’s population will be unable to be vaccinated until 2022.There are 13 vaccine manufacturers working on coronavirus vaccines, and they are capable of producing around 6 billion courses of vaccine by the end of 2021.“Just over half (51%) of these doses will go to high income countries, which represent 14% of the world’s population,” researchers from the Johns Hopkins Bloomberg School of Public Health wrote in their report, published in the British Medical Journal."Of the 13 manufacturers, only six have sold to low and middle-income countries,” they noted.At the time of the report, the U.S. had reserved 800 million doses of the vaccine. Japan and Australia, which account for fewer than 1% of the world’s COVID-19 cases, have reserved and potential options to get 1 billion doses.“Even if all 13 of these vaccine manufacturers were to succeed in reaching their maximum production capacity, at least a fifth of the world’s population would not have access to vaccines until 2022,” researchers noted.Covax, a global effort organized by the World Health Organization, had made initial purchases of 300 million vaccine doses. Covax is working to create equitable access to COVID-19 tests, treatments and vaccines for all countries. President Donald Trump’s administration said they would not participate in the effort."This study provides an overview of how high-income countries have secured future supplies of COVID-19 vaccines, but that access for the rest of the world is uncertain," the researchers concluded. "Governments and manufacturers might provide much-needed assurances for the equitable allocation of COVID-19 vaccines through greater transparency and accountability over these arrangements." 1921

BAKERSFIELD, Calif. (KGTV) — A man accused of boarding a Greyhound bus in San Diego before opening fire and killing one person in the Los Angeles area pleaded not guilty in court.Anthony Devonte Williams, 33, of Capital Heights, Md., pleaded not guilty to one count of first-degree murder and five counts of attempted murder.Williams is accused of opening fire on a bus as it was traveling on Interstate 5 between Los Angeles and Bakersfield on Feb. 3. He reportedly first boarded a bus from San Diego to Los Angeles before boarding another bus in Los Angeles heading to San Francisco.Passengers say Williams was cursing and muttering incoherently before opening fire.The shooting killed 51-year-old Lurbis Elena Vence, of Molino, Colombia, according to KERO., and injured five other people.Other passengers were able to disarm Williams and forced him off the bus. 872

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