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SINGAPORE, Sept. 7 (Xinhua) -- Singapore scientists have found possible new ways to treat a type of aggressive breast cancer that is unresponsive to current forms of treatment, local broadcaster Channel NewsAsia reported on Wednesday.The team of scientists at the Genome Institute of Singapore ( GIS) and National University of Singapore (NUS), led by GIS senior group leader Qiang Yu, found that the enzyme EZH2 acts by inhibiting genes that stop the growth of tumors in the body.The insights could open the door to developing more effective treatment for fast spreading breast cancers, especially the estrogen receptor-negative breast cancer that is common all over the world.It was also found that through EZH2, cancer is promoted in the body by activating specific genes that impact breast cancer progression and cancer stem cell self-renewal.Yu said the new understanding on how EZH2 works as a cancer- causing gene in breast cancer has important therapeutic implication."The results suggest that small molecule drugs that block enzyme activity of EZH2 may not work for cancers caused by EZH2's activation genes," Yu said.Currently pharmaceutical companies have been developing drugs only to the block EZH2 enzyme activity so that tumor suppressers can perform their protective role in blocking cancer growth.Researchers said the next step would be to develop biomarkers to identify tumors with EZH2.This step would enable better treatment methods, with one of options being the development of therapies that shut down EZH2 completely and not just inhibit its enzymatic function.The findings have been published on the journal Molecular Cell.
BEIJING, Sept. 26 (Xinhuanet) -- One of the world's brightest minds aims to bring to the world a new, advanced three-dimensional image technology that will leave other such technology in the shadows."Our new technology will be better than that used in Avatar," says Professor Yau Shing-tung of Harvard University."The image will be more vivid than with technologies used in previous movies. The new technology is not only quicker but cheaper."Yau is one of the world's greatest mathematicians, having won the prestigious Fields Medal. He was once the dean of the department of mathematics at Harvard, and is now a professor there. He is also a visiting professor at Tsinghua University.Professor Yau and his team met professionals from Tsinghua University and Renmin University of China last week, and they discussed possible cooperation to apply the technology in making a demonstration movie using the new technology.Yau and a team started working on the new 3D technology, founded on geometrical principles, at Harvard 10 years ago.What marks it out is the extremely vivid pictures it produces.3D technology is used not only in making movies and in Internet games but in other areas , such as medicine. Movie audiences the world over were awestruck by the technology used in the movie Avatar."After I watched the movie, all I could say was 'Wow'," said Shen Yiren, an IT staff worker in Zhongguancun Science and Technology Park Zone. "3D technology has extended the boundaries of the human imagination."Yau says that six years ago the makers of Avatar had wanted him to cooperate with them but he turned them down."I was not sure that (Avatar) would be such a big success."Avatar's facial caption technology puts points on models' faces while the new technology uses geometric methods, saving time and money, Yau says.
BEIJING, Sept. 26 (Xinhua) -- Nobel laureates on Monday cast doubt on a European experiment that purportedly demonstrated the ability of neutrinos to move faster than the speed of light.They made the remarks in Beijing prior to a forum for Nobel laureates."I'm willing to bet money that it's not correct," said Professor George Smoot III, winner of the 2006 Nobel Prize in Physics and a professor at University of California, Berkeley, referring to an experiment result claiming that particles apparently travel faster than light.The experiment reported an anomaly in the flight time of neutrinos, or electrically neutral subatomic particles, from the European Center for Nuclear Research (CERN) in Switzerland to a laboratory located 730 kilometers away in Italy.Particles were clocked transmitting at a speed of 300,006 kilometers per second, about 60 nanoseconds faster than the speed of light.Smoot said that the claims "did not make sense" and should be verified by other scientists first."There are many distortions in physics. You have to have a very high standard to see if something is truly correct," he said.The unverified findings were published on Sept. 22 in the scientific journal Nature. European researchers working in a team called OPERA (Oscillation Project with Emulsion-Racking Apparatus) projected masses of neutrinos from CERN and then collected the particles using a massive detector in Gran Sasso, south of Rome.Other scientists, as well as the OPERA team themselves, have voiced doubts regarding the experiment's results.The findings, CERN claims, could pose far-reaching potential consequences once verified.If correct, the results would bring Einstein's theory of special relativity into question. Under this theory, a physical object cannot travel faster than the speed of light in a vacuum."If really it is right, we have to rethink everything we know," said Chris Llewellyn Smith, former director of CERN.Smith claimed the unprecedented discovery was too exceptional to find proof."If somebody makes a very exceptional claim, then very exceptional proof would need to come from another experiment, saying the same thing. But we don't have the other thing," Smith said.Carlos Rubbia, a Nobel Laureate who won the prize for physics in 1984, is in charge of a team of more than 100 scientists at CERN."What it is pretending to find, in my view, is unbelievably surprising," Rubbia said."Frankly, I have the feeling that this is still a very experimental consideration," Rubbia said.He also believes that revealing the findings to the public was a mistake as it remained an experimental process and no conclusion could be drawn without the results of another experiment.Despite the possibility of verification, Einstein's special theory of relativity will remain valid."I will be very, very surprised that, at last, Einstein will not be the winner," Rubbia said.To achieve a breakthrough, Rubbia has urged for more joint cooperation on verifying the test results. International cooperation on this issue "is a must.""It requires coordination from all nations," said Rubbia.The 2011 Nobel Laureates Beijing Forum will be held from Sept. 28 to 30 under a theme of "innovation and development."
WASHINGTON, June 21 (Xinhua) -- A new study from Harvard School of Public Health (HSPH) and University of California, San Francisco, researchers suggests that men with prostate cancer who smoke increase their risk of prostate cancer recurrence and of dying from the disease. The study will be published Wednesday in the Journal of the American Medical Association."In our study, we found similar results for both prostate cancer recurrence and prostate cancer mortality," said Stacey Kenfield, lead author and a research associate in the HSPH Department of Epidemiology. "These data taken together provide further support that smoking may increase risk of prostate cancer progression."Kenfield and her colleagues conducted a prospective observational study of 5,366 men diagnosed with prostate cancer between 1986 and 2006 in the Health Professionals Follow-Up Study. The researchers documented 1,630 deaths, 524 (32 percent) due to prostate cancer, 416 (26 percent) due to cardiovascular disease, and 878 prostate cancer recurrences.The researchers found that men with prostate cancer who were current smokers had a 61 percent increased risk of dying from prostate cancer, and a 61 percent higher risk of recurrence compared with men who never smoked. Smoking was associated with a more aggressive disease at diagnosis, defined as a higher clinical stage or Gleason grade (a measure of prostate cancer severity). However, among men with non-metastatic disease at diagnosis, current smokers had an 80 percent increased risk of dying from prostate cancer.Compared with current smokers, men with prostate cancer who had quit smoking for 10 or more years, or who had quit for less than 10 years but smoked less than 20 pack-years before diagnosis, had prostate cancer mortality risk similar to men who had never smoked. Men who had quit smoking for less than 10 years and had smoked 20 or more pack-years had risks similar to current smokers."These data are exciting because there are few known ways for a man to reduce his risk of dying from prostate cancer," said senior author Edward Giovannucci, professor of nutrition and epidemiology at HSPH. "For smokers, quitting can impact their risk of dying from prostate cancer. This is another reason to not smoke."Prostate cancer is the most frequently diagnosed form of cancer diagnosed in the United States and the second leading cause of cancer death among U.S. men, affecting one in six men during their lifetime. More than two million men in the U.S. and 16 million men worldwide are prostate cancer survivors.
WASHINGTON, July 27 (Xinhua) -- Astronomers studying observations taken by NASA's Wide-field Infrared Survey Explorer (WISE) mission have discovered the first known "Trojan" asteroid orbiting the sun along with Earth, the U.S. National Aeronautics and Space Administration (NASA) announced Wednesday in a statement.Trojans are asteroids that share an orbit with a planet near stable points in front of or behind the planet. Because they constantly lead or follow in the same orbit as the planet, they never can collide with it. In our solar system, Trojans also share orbits with Neptune, Mars and Jupiter. Two of Saturn's moons share orbits with Trojans.Scientists had predicted Earth should have Trojans, but they have been difficult to find because they are relatively small and appear near the sun from Earth's point of view."These asteroids dwell mostly in the daylight, making them very hard to see," said Martin Connors of Athabasca University in Canada, lead author of a new paper on the discovery to be published Thursday in the journal Nature. "But we finally found one, because the object has an unusual orbit that takes it farther away from the sun than what is typical for Trojans. WISE was a game-changer, giving us a point of view difficult to have at Earth 's surface."The WISE telescope scanned the entire sky in infrared light from January 2010 to February 2011. Connors and his team began their search for an Earth Trojan using data from NEOWISE, an addition to the WISE mission that focused in part on near-Earth objects, or NEOs, such as asteroids and comets. NEOs are bodies that pass within 28 million miles (45 million kilometers) of Earth 's path around the sun. The NEOWISE project observed more than 155, 000 asteroids in the main belt between Mars and Jupiter, and more than 500 NEOs, discovering 132 that were previously unknown.The team's hunt resulted in two Trojan candidates. One called 2010 TK7 was confirmed as an Earth Trojan after follow-up observations with the Canada-France-Hawaii Telescope on Mauna Kea in Hawaii.The asteroid is roughly 1,000 feet (300 meters) in diameter. It has an unusual orbit that traces a complex motion near a stable point in the plane of Earth's orbit, although the asteroid also moves above and below the plane. The object is about 50 million miles (80 million kilometers) from Earth. The asteroid's orbit is well-defined and for at least the next 100 years, it will not come closer to Earth than 15 million miles (24 million kilometers).