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WASHINGTON, April 11 (Xinhua) -- In the first clinical trial of gene therapy for treatment of intractable pain, U.S. researchers from the University of Michigan's Department of Neurology observed that the treatment appears to be able to provide substantial pain relief.In a study published online in the Annals of Neurology and seen on Monday, the researchers showed that the novel agent NP2 is safe and well-tolerated. In addition, measures of pain in the treated patients suggested that NP2 may provide a substantial analgesic effect.NP2 is a gene transfer vector that expresses the naturally- occurring opioid peptide enkephalin. In preclinical work in animals, David Fink, chair of the Department of Neurology, and his coworkers had demonstrated that injection of NP2 into the skin reduces pain in models of pain caused by nerve damage, inflammation or cancer.In the clinical trial, 10 patients with unrelenting pain caused by cancer were injected with the gene transfer agent in the area of skin related to the location of pain."The concept underlying this therapeutic approach is that injection of NP2 into the skin results in uptake into the nervous system and the production and release of a pain-relieving chemical in a controlled site in the pain pathway," says Fink. "In the study, patients who received the low dose of vector showed little reduction in pain; patients receiving the higher doses showed a greater than 80 percent reduction in pain over the course of four weeks following treatment."Fink's laboratory has been working on the use of modified herpes simplex virus-based vectors that are taken up by sensory nerves following skin injection to develop therapies for diseases of the nervous system for more than 20 years. Patents related to this technology have been exclusively licensed by Diamyd Medical, a publicly-traded Swedish biotechnology company that sponsored the trial, and the human-grade vector NP2 was produced by Diamyd, Inc, the U.S. subsidiary of Diamyd Medical.A phase 2 trial to compare NP2 to a placebo control has already been initiated under sponsorship from Diamyd.

BEIJING, March 10 (Xinhuanet) -- The price of preventing preterm labor is about to rise drastically in the U.S. next week.A drug for high-risk pregnant women costs about 10 to 20 dollars per injection. Next week, the price will shoot up to 1,500 dollars a dose, according to media reports Wednesday.This means the total cost during a pregnancy could be as much as 30,000 dollars.The massive increase comes after KV Pharmaceutical of St. Louis won an exclusive government license to produce the drug, known as Makena.The drug, a form of progesterone given as a weekly shot, has been made cheaply for years by unlicensed chemists.The March of Dimes and many obstetricians supported the move because it means quality will be more consistent and it will be easier to get, but none of them has anticipated the sharp price hike.Doctors and campaign groups have been caught out by the move, saying that the price hike may deter low-income women from getting the drug, leading to more premature births.

BEIJING, Feb. 24 (Xinhua) -- Chinese Premier Wen Jiabao attended the opening ceremony of the China-EU Year of Youth in Beijing on Wednesday, encouraging young people from China and the EU to build a brighter future for bilateral strategic partnerships.Joining over 500 young people from China and the EU in the Capital Museum in downtown Beijing, Wen said that the year-long youth exchange campaign was the first theme year between China and the EU since the establishment of diplomatic ties, and is also the largest-ever China-EU cultural exchange program."This has revealed that our relations will be more vibrant in the future and full of hopes," he added.China and the EU are in a vital period for deepening cooperation, Wen said, calling on young people from both sides to consider and explore ways to share opportunities, meet challenges and seek common development, which has benefits for China, the EU and the world.Wen hopes that young people from both sides would always be brave in pursuing innovation and the truth. He also encouraged them to learn from each other in a frank and open spirit, in a bid to jointly create a better future for China-EU ties.A video speech from European Commission President Jose Manuel Barosso was aired at the ceremony. He said that the Year of Youth offers an interactive platform for European and Chinese young people to enhance mutual understanding and friendship and also inject vitality to China-EU relations.Premier Wen and Barroso jointly initiated The China-EU Year of Youth during the 12th EU-China summit held in 2009.Along with the opening ceremony in Beijing, Chinese and European youth were immersed in two-day discussions on topics such as culture, education, volunteering, creativity and environmental protection starting on Tuesday."We had excellent discussions on possible cooperation projects, ranging from environmental protection, world heritage to art and intellectual property," said Pierre Arlaud, a member of an EU youth delegation that arrived in Beijing on Monday to participate in the opening ceremony."I can feel there is a strong will from both sides to deepen understanding and forge a stronger partnership," he added.The opening ceremony was the first in a series of exchange activities that will be held throughout the year in China and Europe. The events include cultural seminars, volunteer service conferences, youth summer camps and TV debates.The year-long program was co-hosted by the All-China Youth Federation and the European Commission. The initiative aims to promote intercultural dialogue and strengthen mutual understanding and friendship between young people in China and the EU, as well as encouraging them to support the development of China-EU relations.

ABUJA, Jan. 28 (Xinhua) -- China and Nigeria celebrated the 40th anniversary of the establishment of diplomatic relations on Thursday evening in Nigeria's capital city Abuja.More than 600 Chinese and Nigerian guests, including Nigeria's former Head of State Yakubu Gowon, attended the gala event.On Feb. 10, 1971, the two most populous developing countries in Asia and Africa set up their diplomatic relations, said Deng Boqing, the Chinese ambassador to Nigeria.The frequent high level visits from both sides built up the mutual trust, the exchanges and cooperation in the fields of economy, culture, science, education and health, he said.The bilateral trade volume in 2010 is expected to break the record 7.5 billion U.S. dollars in 2008. The total Chinese investment in Nigeria has been nearly 8 billion dollars by the end of 2010, he said.Deng also gave tribute to the indispensable efforts made by the overseas Chinese and Chinese companies in Nigeria.Yakubu Gowon, former head of state in the 1970s, told Xinhua that he was delighted to witness the establishment of diplomatic ties between China and Nigeria in 1971 during his term. He visited China and met the late Chinese leader Mao Zedong in 1974.Nigeria's President Goodluck Jonathan sent his representative to the celebration of the 40th anniversary of bilateral ties, pledging the two countries would work closely in the future.

JERUSALEM, March 31 (Xinhua) -- Two researchers at the Hebrew University (HU) of Jerusalem have been honored with a prestigious award for their study of the connection between several inflammatory diseases, cancer and bacteria.Medical faculty members, Dr. Eli Pilarsky and Prof. Sigal Ben- Yehuda, won this year's Sir Zelman Cowen Universities Fund prize that recognizes significant achievement in the field of medicine.The prize committee noted the impressive contributions of Pilarsky and Ben-Yehuda in understanding complex diseases like cancer and antibiotic-resistant infections, and, in a first, decided to award the two scientists this year.Pilarsky told Xinhua that his research deals with the connection between chronic inflammatory diseases like hepatitis, and the development of cancer cells."The relevance of this discovery is that we were able to establish the link between the molecules secreted with such inflammations and the proliferation of cancer cells," Pilarsky explained, noting that "we discovered that the inflammation favors the cancer cells' growth, and now we are trying to find a way to manipulate these molecules to stop the cancer cells from appearing. ""The importance of these findings lies in the fact that 20 percent of the world's cancer cases are attributed to inflammation processes," Pilarsky pointed out.

来源：资阳报